DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16779 and CoRest

DIOPT Version :9

Sequence 1:	NP_001287254.2	Gene:	CG16779 / 41134	FlyBaseID:	FBgn0037698	Length:	2005	Species:	Drosophila melanogaster
Sequence 2:	NP_001188671.1	Gene:	CoRest / 32941	FlyBaseID:	FBgn0261573	Length:	824	Species:	Drosophila melanogaster

Alignment Length:	812	Identity:	157/812 - (19%)
Similarity:	254/812 - (31%)	Gaps:	309/812 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SASVGTEGSVTLQLRDANALEAAATKTATAAAAAAAAAAATSTTSPNGVAGAPASTLENALTIG- 91
            |||:...|:.:....:|||.|  .|.||...|....::...::|..||.:.|..|..|..:.:|
  Fly    34 SASLVGSGNNSGHSGNANANE--KTTTAVPGAGTPESSDDDNSTKRNGKSKAKQSEYEEKIRVGR 96

  Fly    92 ---------YPDPEMLADVLG---------TIQTASLKNNNSITAATSSNSSTKSTS-------- 130
                     .|:.|...:.:.         |.:...||....|:.|..........:
  Fly    97 DYQAVCPPLVPEAERRPEQMNERALLVWSPTKEIPDLKLEEYISVAKEKYGYNGEQALGMLFWHK 161

  Fly   131 ----------SNHLTNPNKITIK------------RRSVHSV----------------------- 150
                      :|....|::.||:            .:|.|.:
  Fly   162 HDLERAVMDLANFTPFPDEWTIEDKVLFEQAFQFHGKSFHRIRQMLPDKSIASLVKYYYSWKKTR 226

  Fly   151 ------------------STSTNSSSISSCSSSSSSSNSGKSNTSYIKNCLIRSSSCSNTVTNVT 197
                              ..|.|.|.:.|...|.:....|....|.|......::|.:|:.|
  Fly   227 HRSSAMDRQEKAIKAVVKDGSENGSEVGSNEESDNDDKKGHGTNSTINTIDATTTSTNNSTT--- 288

  Fly   198 TLAQIMSNSSTSSAASLLNQHNNNSNCSNSSNFSTASSVGSSISVGSNSSSSNCS--NGSNSNSN 260
                   ||:|::.|:::      :|..||::.|:.|..|.:|   :|:...|..  .|||:.||
  Fly   289 -------NSNTTTPANII------ANTINSNHSSSNSGGGGNI---NNNGEENIQAVGGSNTISN 337

  Fly   261 DSNSSSGGGHRLSFKGTGR--HVPASGLSSSAA------STNTNGTVSG---------IGGIISV 308
            .||:.........|.|..:  .:.|.||::..|      :.|.||.:.|         :||...:
  Fly   338 TSNNDMDAEQLSLFAGNAQIEEMMALGLAADRAIGANGGNNNNNGEMGGDPGLMRRMVVGGFCKI 402

  Fly   309 ---------EAP------------RK--NRPKLSSPTRHGPQQCQICCKIFGNASALAKHK---L 347
                     ::|            |:  ||..:|.|..:.|::....|....:.|.....|   :
  Fly   403 CNVVCHVLHDSPLGRMCKSCHTHWRRTGNRRPISGPEGNAPRRSTHNCAATADRSKRKPPKGMYI 467

  Fly   348 THSD-----------------ERKYICALCSK--------------------------------- 362
            .|.|                 ||| :.||.::
  Fly   468 NHDDLTALASCGNPSLYLAERERK-LTALMAEIQKNRQVMEQLDKECETINVDDVLSKPAAANTE 531

  Fly   363 ------------------------------------AFKRQDHLNGHMMTHRNK-------KPYE 384
                                                |.|.:.|:....:.:|.:       |.||
  Fly   532 SAQPRISARWLPDEIQVALLAIREYGKNFPTIAKVVATKTEAHVRTFYLNNRRRYNLDQIVKEYE 596

  Fly   385 CKADGCGKS-YCDARSLRRHSENHHAGGAATPTTSQSLSPTASSSGTSN------SSGAGAATSS 442
                 .||| ...|......:.:..|.||||.:...:...|:::|.|::      :|..|..|..
  Fly   597 -----AGKSEESGAEEQTEPAVDAAAAGAATASAPSAADSTSAASATADRKQSTENSNNGVETMQ 656

  Fly   443 LSL-------SPATAS-----GDASSPDGATCIRTYISTGSSVVDAATG---------IALSDEQ 486
            .||       .|..|:     |.|.:.|....:.:  ||.|.|:.|||.         |.:.||.
  Fly   657 ESLPKKEDPKKPELAAAVLKIGVAEAADAVATVAS--STASGVIGAATSASKPSTSATITIIDES 719

  Fly   487 IKAMN---------LPIKTGVTLLSPTTS--------TSSNASSSASSASSSLSATGSLPGSGSG 534
            ..|.|         |...||.:.||.|||        :|...|:..|:.:|.::|.|:..|.|..
  Fly   720 DTATNSSSDVVTTGLATSTGSSALSSTTSAPASKTQTSSEELSAQKSNPASGIAAIGAATGGGQT 784

  Fly   535 SGSVSMAPSPSSGSVITAC----SPTITLSDG 562
            :.|   :.|....||:...    :..|.||.|
  Fly   785 ANS---SGSKRDSSVLPVAEQPPAKKIALSTG 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16779	NP_001287254.2	C2H2 Zn finger	329..349	CDD:275368	3/22 (14%)
		zf-C2H2	355..377	CDD:395048	5/90 (6%)
		C2H2 Zn finger	357..377	CDD:275368	5/88 (6%)
		C2H2 Zn finger	385..407	CDD:275368	4/22 (18%)
		ELM2	1647..1696	CDD:396160
		SANT	1738..1782	CDD:419695
		C2H2 Zn finger	1810..1832	CDD:275368
		zf-C2H2_6	1952..1975	CDD:404748
		C2H2 Zn finger	1954..1974	CDD:275368
CoRest	NP_001188671.1	ELM2	92..144	CDD:279754	8/51 (16%)
		SANT	179..225	CDD:197842	4/45 (9%)
		SANT	180..224	CDD:304392	4/43 (9%)
		SANT	540..582	CDD:238096	3/41 (7%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452315
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR16089
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940