DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIa and AMS1

DIOPT Version :9

Sequence 1:	NP_001262413.1	Gene:	alpha-Man-IIa / 41126	FlyBaseID:	FBgn0011740	Length:	1109	Species:	Drosophila melanogaster
Sequence 2:	NP_011359.1	Gene:	AMS1 / 852721	SGDID:	S000003124	Length:	1083	Species:	Saccharomyces cerevisiae

Alignment Length:	902	Identity:	189/902 - (20%)
Similarity:	318/902 - (35%)	Gaps:	219/902 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 QCQDVVQDVPNVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPG 158
            :|::::|         .|.:|  ||.: ...|::||          .:.....|:.:.:.|.|..
Yeast   260 KCRELLQ---------REYFD--SFLE-SSKVYEQG----------ESQVLTNVYGIGNCHIDTA 302

  Fly   159 WIQTFEEYYQHDTKHILSNALRHLHDN-PEMKFIWAEISYFARFYHDLGE--NKKLQMKSIVKNG 220
            |:..|.|..:...:...|...  |.|. ||.||:.::...|.....|..|  ||.|..|  ::..
Yeast   303 WLWPFAETRRKIVRSWSSQCT--LMDRFPEYKFVASQAQQFKWLLEDHPEFFNKVLIPK--IQQS 363

  Fly   221 QLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGF 285
            |...|.|.||..|.......::..|...||.:..:...:.....|..|.||:|..||.:.:.||.
Yeast   364 QFFAVGGTWVENDTNIPSGESLARQFFFGQRFFLKHFGLKSKIFWLPDTFGYSSQMPQLCRLSGI 428

  Fly   286 KNMLIQRTHYSVKKELAQQRQLEFLWRQI---------WDNKGDTALFTHMMPFYSYDIPHTCGP 341
            ...|.|:                ..|..|         |.....:.|.|||.|..:|......|
Yeast   429 DKFLTQK----------------LSWNNINSFPHSTFNWAGIDGSQLLTHMPPGNTYTADSHFG- 476

  Fly   342 DPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDF 406
                    |..|                .:.||             |..|.|.:.::|...||.
Yeast   477 --------DVLR----------------TAKQN-------------KTPEYYGSGLMLYGKGDG- 503

  Fly   407 RFKQNTEWDVQRVNYERLFEHINSQAHFNV--QAQFG-TLQEYFDAVHQAERAGQAEFPTLSGDF 468
             ....||..:|::...|...:.|.    ||  :.|.| |:.|::|.:.:....|. :.||.||:.
Yeast   504 -GGGPTEEMLQKMRRIRSMNNRNG----NVIPKLQVGITVDEFYDDILKRTNQGH-DLPTWSGEL 562

  Fly   469 FTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEMLSAWHSW---DGMARIEERLEQARRELS 530
            :.      .:..|.|||:...|::.|:....:...|.::|..|.   |......:::.:....:.
Yeast   563 YF------EFHRGTYTSQAQTKKLMRLSEIKLHDLEWIAAKTSVLYPDSYKYPSKQINELWENVL 621

  Fly   531 LFQHHDGITGTAKTHVVVDYE--QRMQEALKACQMVMQQSV-------------YRLLT--KPSI 578
            |.|.||.:.|:. ..:|..||  ..:...:|.|..::.::|             .|.||  ||..
Yeast   622 LCQFHDVLPGSC-IEMVYKYEAVPMLHNVVKECTSLIDKTVQFLQSQSKADLVEMRTLTWSKPEK 685

  Fly   579 YSPDFSFS------------YFTLDDSR-----WPGSGVEDSRTTIILGEDILPSKH-------- 618
            .|.:.|.:            |..|.:.:     ...:||..|.|...||.:.|.::|
Yeast   686 VSEECSLNGSYTSSVTGYDDYIVLANGKLKVIICKKTGVITSITDETLGVEYLDTEHGRNKLGAN 750

  Fly   619 -VVMHNTLP----HWREQLVDF----YVSSPFVSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQ 674
             .|:::..|    .|..:|...    ||:.| ..|....|...:..|..::........|::...
Yeast   751 QFVIYDDKPLGWQAWDTELYSVNQYKYVTKP-KKVQVSCNTKEKCAVEVIFQISEKCKIKSVISL 814

  Fly   675 GSTTKYRIIFKARVPPMGLATYV---------LTIS---DSKPEHTSYASNLLLRKNP----TSL 723
            .:|.    :..|::..:.::|.|         |.:.   :.:.:..||.:...:.|.|    ||.
Yeast   815 NATA----VTDAKLSKVDISTTVENWDARNKFLKVEFPVNIRNDFASYETQFGITKRPTHYNTSW 875

  Fly   724 PLGQYPEDV---KFGDPREISLRVG--NGPTLAFSEQGLLKSIQLTQDSPHVP-VHFKF----LK 778
            .:.::  :|   ||.|..|.|..|.  |.....||..|.|..:.|.: ||..| .|...    :|
Yeast   876 DVAKF--EVCHHKFADYSEYSKGVSILNDCKYGFSTHGNLMRLSLLR-SPKAPDAHADMGTHEIK 937

  Fly   779 YGVRSHGDRSGAYLFLPNGPASPVELGQPVVLVTKGKLESSVSV---------GLPSVVHQTIMR 834
            |.:..|   .||.      .:..|:|........|.||...:.:         |..:|:...|.|
Yeast   938 YAIYPH---RGAL------SSDTVKLAHEFNYCFKYKLPKDIGMNFDDIISISGDENVILSNIKR 993

  Fly   835 G-GAPEIRNLVDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKR-RRLDKLPLQ 889
            | ....:::...:...|...||:|:...:  |...:..||....:|| .::|.|.::
Yeast   994 GEDDSAVKSNYSLNPRDEQSIVVRVYESL--GGESFASLNTTLNLKRIEKVDNLEMK 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	78/353 (22%)
		Alpha-mann_mid	478..554	CDD:214875	18/80 (23%)
		Glyco_hydro_38C	744..1103	CDD:285047	37/164 (23%)
AMS1	NP_011359.1	AMS1	44..1083	CDD:223460	189/902 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344085
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3970
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.870