DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIa and GMII

DIOPT Version :9

Sequence 1:	NP_001262413.1	Gene:	alpha-Man-IIa / 41126	FlyBaseID:	FBgn0011740	Length:	1109	Species:	Drosophila melanogaster
Sequence 2:	NP_196999.1	Gene:	GMII / 831347	AraportID:	AT5G14950	Length:	1173	Species:	Arabidopsis thaliana

Alignment Length:	1169	Identity:	433/1169 - (37%)
Similarity:	594/1169 - (50%)	Gaps:	224/1169 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LAETSNRDDPIRPPLKVARSPRPGQCQDVVQDVPNVDVQMLELYDRMSFKDIDGGVWKQGWNIKY 134
            |...|||  .::|...:.|.|........|     ||:...:||||:.|.|.|||.|||||.:.|
plant    86 LTSRSNR--IVKPRKNINRRPLNDSNSGAV-----VDITTKDLYDRIEFLDTDGGPWKQGWRVTY 143

  Fly   135 DPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFA 199
            ...::. ..|||:||||||||||||..|.|||||..::|||...:..|..:...||||.|:||..
plant   144 KDDEWE-KEKLKIFVVPHSHNDPGWKLTVEEYYQRQSRHILDTIVETLSKDSRRKFIWEEMSYLE 207

  Fly   200 RFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFMNVTPTAS 264
            |::.|...||:..:..:||:||||.|.|||||.||||||:..::.|:.||..||...:.|.|..|
plant   208 RWWRDASPNKQEALTKLVKDGQLEIVGGGWVMNDEANSHYFAIIEQIAEGNMWLNDTIGVIPKNS 272

  Fly   265 WAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMP 329
            |||||||:|.||.|:|::.||:|||||||||.:||:|||.:.||::|||.||....|.:|.||||
plant   273 WAIDPFGYSSTMAYLLRRMGFENMLIQRTHYELKKDLAQHKNLEYIWRQSWDAMETTDIFVHMMP 337

  Fly   330 FYSYDIPHTCGPDPKVCCQFDFKRMGSFGLS-CPWKVPPRTISDQNVAARSDLLVDQWKKKAELY 393
            ||||||||||||:|.:||||||.||..|... |||...|...:.:||..|:..|:||::||:.||
plant   338 FYSYDIPHTCGPEPAICCQFDFARMRGFKYELCPWGKHPVETTLENVQERALKLLDQYRKKSTLY 402

  Fly   394 RTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQEYFDAV-HQAER-- 455
            |||.||||||||||:....|.:.|..||:.||:||||....|.:|:||||::||..| .:|:|
plant   403 RTNTLLIPLGDDFRYISIDEAEAQFRNYQMLFDHINSNPSLNAEAKFGTLEDYFRTVREEADRVN 467

  Fly   456 --------AGQ-AEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEMLSAW-- 509
                    :|| ..||:|||||||||||..:||||||.|||:.|.:||||.|.:|.||::.::
plant   468 YSRPGEVGSGQVVGFPSLSGDFFTYADRQQDYWSGYYVSRPFFKAVDRVLEHTLRGAEIMMSFLL 532

  Fly   510 ---HSWDGMARIE---------ERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQ 562
               |      ||:         .:|..|||.|:|||||||:|||||.:||.||..||..:|:..|
plant   533 GYCH------RIQCEKFPTSFTYKLTAARRNLALFQHHDGVTGTAKDYVVQDYGTRMHTSLQDLQ 591

  Fly   563 MVMQQSVYRLL----------TKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSK 617
            :.|.:::..||          ..||.:..:...|.:.......|.:..|.:..|:||   ..||:
plant   592 IFMSKAIEVLLGIRHEKEKSDQSPSFFEAEQMRSKYDARPVHKPIAAREGNSHTVIL---FNPSE 653

  Fly   618 HVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQGSTTKYRI 682
            ..         ||::|...|:...:||.|.....|.:|:||  ...||. ||..     |.::|:
plant   654 QT---------REEVVTVVVNRAEISVLDSNWTCVPSQISP--EVQHDD-TKLF-----TGRHRL 701

  Fly   683 IFKARVPPMGLATYVLT-----ISDSKPEHTSYASNLLLRKNPTSLPLGQYPE------------ 730
            .:||.:|.:||.||.:.     ...:.|....|||..    :|...|    |.
plant   702 YWKASIPALGLRTYFIANGNVECEKATPSKLKYASEF----DPFPCP----PPYSCSKLDNDVTE 758

  Fly   731 ----------DVKFGDPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHG 785
                      |||.|..|:|..|.|: .|:...|.|:..|
plant   759 IRNEHQTLVFDVKNGSLRKIVHRNGS-ETVVGEEIGMYSS------------------------- 797

  Fly   786 DRSGAYLFLPNGPASPVE------------LGQPVVLVTKGKLESSVSVGLPSVVHQTIMRGG-- 836
            ..||||||.|:|.|.|:.            |.|.|....|.|.|.|     |......:..||
plant   798 PESGAYLFKPDGEAQPIVQPDGHVVTSEGLLVQEVFSYPKTKWEKS-----PLSQKTRLYTGGNT 857

  Fly   837 ----APEIRNLVDI--GSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPI 895
                ..||...|::  ...|:.|:::|.:|.:|:..:||:||||.|..:|...||:|||.||||:
plant   858 LQDQVVEIEYHVELLGNDFDDRELIVRYKTDVDNKKVFYSDLNGFQMSRRETYDKIPLQGNYYPM 922

  Fly   896 PSGMFIEDAN-TRLTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLV 959
            ||..||:.:| .|.::.:.|.||.:||..|.||||.||||..||.|||||||:||:.:..::.|:
plant   923 PSLAFIQGSNGQRFSVHSRQSLGVASLKEGWLEIMLDRRLVRDDGRGLGQGVMDNRAMTVVFHLL 987

  Fly   960 LEKVNNCVRPSELHPAGYLTSAAHKASQSLLD---------PLDKFIFAENEWIGAQ-GQFGGDH 1014
            .|.     ..|:..||    |..:..:.|||.         |::.||..:.:.|..: .|:|...
plant   988 AES-----NISQADPA----SNTNPRNPSLLSHLIGAHLNYPINTFIAKKPQDISVRVPQYGSFA 1043

  Fly  1015 PSARE---DLDVSVMR--RLTKSSAKTQ----RVGYVLHRT--NLMQCGTPEEHTQKLDVCHLLP 1068
            |.|:.   ||.:...:  |.:|.|.:.:    |...:|:|.  :...|     |..:...|..:.
plant  1044 PLAKPLPCDLHIVNFKVPRPSKYSQQLEEDKPRFALILNRRAWDSAYC-----HKGRQVNCTSMA 1103

  Fly  1069 N-------------VARCERTTLTFLQ-NLEHL---------------DGMVAPEVCPMETAAY 1103
            |             .::.:.|:|..|| ::|.|               :|.|:  :.|||..||
plant  1104 NEPVNFSDMFKDLAASKVKPTSLNLLQEDMEILGYDDQELPRDSSQPREGRVS--ISPMEIRAY 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	192/351 (55%)
		Alpha-mann_mid	478..554	CDD:214875	42/89 (47%)
		Glyco_hydro_38C	744..1103	CDD:285047	121/429 (28%)
GMII	NP_196999.1	PLN02701	114..1170	CDD:178304	425/1134 (37%)
		GH38N_AMII_GMII_SfManIII_like	152..504	CDD:212120	192/351 (55%)
		Alpha-mann_mid	499..583	CDD:214875	42/89 (47%)
		Glyco_hydro_38C	755..1165	CDD:285047	128/456 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	381	1.000	Domainoid score	I163
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55954
Inparanoid	1	1.050	638	1.000	Inparanoid score	I189
OMA	1	1.010	-	-		QHG55783
OrthoDB	1	1.010	-	-		D1101882at2759
OrthoFinder	1	1.000	-	-		FOG0002281
OrthoInspector	1	1.000	-	-		oto3208
orthoMCL	1	0.900	-	-		OOG6_102728
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2015
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840