Protein Alignment alpha-Man-IIa and Man2c1

DIOPT Version :10

• Sequence 1: NP_001262413.1
• Gene: alpha-Man-IIa / 41126
• FlyBaseID: FBgn0011740
• Length: 1109
• Species: Drosophila melanogaster
• Sequence 2: XP_006511557.1
• Gene: Man2c1 / 73744
• MGIID: 1920994
• Length: 1106
• Species: Mus musculus
• Alignment Length: 874
• Identity: 162/874 - (18%)
• Similarity: 285/874 - (32%)
• Gaps: 274/874 - (31%)

  Fly    11 VICSGCLLVFLSLYIILNFAAPAATQIKQPN-------YENIENKLHELE------NGLQEHGEE 62
            |.|:|.|.......|    |||...::.|.:       :.::.:.|.:||      .||.|  :.
Mouse   173 VACNGLLGAGKGSMI----AAPDPEKMFQLSQAKLAVFHRDVHSLLVDLELLLGVAKGLGE--DS 231

  Fly    63 MRNLRARLAETSNR----DDPIRP---PLKVARSPR-----PGQCQDVVQDVPNVDV-------- 107
            .|:.:|  ..|:|:    .||.:|   |...|.:.:     .|:.|..:..:.:..:
Mouse   232 QRSFQA--LHTANQMVNICDPAQPETYPAAKALASKFFGQHGGESQHTIHAMGHCHIDTGVSRCT 294

  Fly   108 -------QMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEE 165
                   |:|.:..:|..:.:   ..:||              .:|:.:.|.:     |:..|:|
Mouse   295 SKCVFFSQLLAVLIQMQLRFL---TMEQG--------------LMKLDLRPRA-----WLWPFKE 337

  Fly   166 YYQHDTKHILSNALRHLHDNPEMKFI--------WAEISYFARFYHDLGENKKLQMKSIVKNGQL 222
            ..:...:. .|.|:..:..|.:..|.        |.:..|       .|.:.:||  .....||.
Mouse   338 TVRKCARS-WSTAVTLMEQNTDFIFACSQAQQLEWVKSQY-------PGLHARLQ--EFACRGQF 392

  Fly   223 EFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKN 287
            ..|.|.||..|........::.|..:||.:..|......:..|..|.||:|..:|.|:|..|.|.
Mouse   393 VPVGGTWVEMDGNLPSGEAMVRQFLQGQNFFLQEFGKMCSEFWLPDTFGYSAQLPQIMQGCGIKR 457

  Fly   288 MLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFK 352
            .|.|:..:::.......       ...|:....:.:..|..|..||
Mouse   458 FLTQKLSWNLVNSFPHH-------TFFWEGLDGSRVLVHFPPGDSY------------------- 496

  Fly   353 RMGSFGLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQ 417
                 |:....:...:|:::.....|::              .:..|...||.......|..|
Mouse   497 -----GMQGSVEEVLKTVTNNRDKGRTN--------------HSGFLFGFGDGGGGPTQTMLD-- 540

  Fly   418 RVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGY 482
              ..:||     |......:.|..:..:.|.|:.:    ...:..|..|:.|.      ...:|.
Mouse   541 --RLKRL-----SNTDGLPRVQLSSPGQLFTALER----DSGQLCTWVGELFL------ELHNGT 588

  Fly   483 YTSRPYHKRMDRVLMHYVRAAEMLSAWHSWDGMARIEE------RLEQARRELSLFQHHDGITGT 541
            ||:....|:.:|.....:...|:||:.    .:||..:      :|:...|.|.|.|.||.:||:
Mouse   589 YTTHAQLKKGNRECEQILHDVEVLSSL----ALARSAQFLYPAAQLQHLWRLLLLNQFHDVVTGS 649

  Fly   542 AKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTT 606
                              ..|:|.:.::                :|:  :|.|..|:.:..:...
Mouse   650 ------------------CIQLVAEDAM----------------NYY--EDIRSHGNPLLSAAAA 678

  Fly   607 IILGEDILPSKHVVMHNTLPHWREQLVDF-----YVSSPFVSVTDLANNPVEAQVS--------P 658
            .:...:..| |.:::.||||..|.:::..     ..|...|:|..:...|.....|        |
Mouse   679 ALCAGEPGP-KGLLIINTLPWKRTEVLALPKPCGAHSLALVTVPSIGYAPAPTPTSLQPLLPQQP 742

  Fly   659 VWSWHHDTLTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSL 723
            |:     .:.:|   .||.|....|.:.|:.|.|..|.::.::..:......|
Mouse   743 VF-----VMQET---DGSVTLDNGIIRVRLDPTGCLTSLVLVASGREAIAEGA------------ 787

  Fly   724 PLGQYPEDVKFGD-----------PREISLR---VGNGPTLAFSEQGLLKSIQ--LTQDSP---- 768
             ||.  :.|.|.|           ...:..|   :|...|||...:|.|:...  |.|.||
Mouse   788 -LGN--QFVLFDDVPLYWDAWDVMDYHLETRKPVLGQAGTLAVGTEGGLRGSAWFLLQISPNSRL 849

  Fly   769 ---------------HVPVHF----KFLK 778
                           |..||:    ||||
Mouse   850 SQEVVLDVGCPYVRFHTEVHWHEAHKFLK 878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	PLN02701	105..990	CDD:178304	136/755 (18%)
		Glyc_hyd_38C_2	1020..1108	CDD:408054
Man2c1	XP_006511557.1	MngB	272..1099	CDD:440152	138/767 (18%)