Protein Alignment alpha-Man-IIa and man2a2

DIOPT Version :9

• Sequence 1: NP_001262413.1
• Gene: alpha-Man-IIa / 41126
• FlyBaseID: FBgn0011740
• Length: 1109
• Species: Drosophila melanogaster
• Sequence 2: NP_001006777.1
• Gene: man2a2 / 448465
• XenbaseID: XB-GENE-981388
• Length: 909
• Species: Xenopus tropicalis
• Alignment Length: 955
• Identity: 391/955 - (40%)
• Similarity: 569/955 - (59%)
• Gaps: 129/955 - (13%)

  Fly     2 LRIRRRFALVICSG---CLLVFLSLYIILNFAAPAATQIKQPNYEN-----------IENKLHEL 52
            ::::::  :.:|..   |:.|| |||::|:     ..|...|..:|           ::|::.:|
 Frog     1 MKLKKQ--VTVCGAAIFCVAVF-SLYLMLD-----KVQHDPPRRQNGGNFPRSQISVLQNRIEQL 57

  Fly    53 ENGLQEHGEEMRNLRARLAE-TSNRD-DPIRPPLKVAR-------SPRPG-------QCQ-DVVQ 100
            |..|:|:.|.:.:::..:.| |:|.: .||..|.....       .|||.       .|| .|..
 Frog    58 EQLLEENHEIISHIKDSVLELTANAEGQPILLPYHTPNGTWVMPPDPRPSFYSVSPQDCQFSVAN 122

  Fly   101 DVPNVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEE 165
            .....|:|||::|.::.|.::||||||||::|.|||.::: :..|:||||||||||||||:||::
 Frog   123 KRQKTDLQMLDVYTQLPFDNVDGGVWKQGFDITYDPKEWD-NEPLQVFVVPHSHNDPGWIKTFDK 186

  Fly   166 YYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWV 230
            ||...|:|||:|.:..||::|..||||:|||:|::::.::...|:..::.:|.:||||..|||||
 Frog   187 YYYDQTQHILNNMVVKLHEDPRRKFIWSEISFFSKWWDNINSQKRAAVRRLVASGQLEMTTGGWV 251

  Fly   231 MPDEANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHY 295
            ||||||:|:..::.|:.||..|||:.::.||.:.||:||||||.||||||::|...:|||||.||
 Frog   252 MPDEANTHYFAMIDQMIEGHQWLKKNLDATPRSGWAVDPFGHSSTMPYILRRSNLTSMLIQRVHY 316

  Fly   296 SVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLS 360
            |:||..|..:.|||:|||.||....|.:|.|||||||||:|||||||||:||||||:|:....::
 Frog   317 SIKKHFAATQSLEFMWRQTWDPDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFRRLPGGRIN 381

  Fly   361 CPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLF 425
            ||||||||.|:|.|||.|:::|:||:|||::|||:.|:|:|||||||:.:..|||.|.:||::||
 Frog   382 CPWKVPPRAITDSNVAERANILLDQYKKKSKLYRSKVVLVPLGDDFRYDKIQEWDAQFLNYQKLF 446

  Fly   426 EHINSQAHFNVQAQFGTLQEYFDAVHQAERAG------QAEFPTLSGDFFTYADRSDNYWSGYYT 484
            :::||....:||||||||.:||||::  :|.|      ..:||.:|||||:||||.|:||:||||
 Frog   447 DYMNSHPELHVQAQFGTLSDYFDALY--KRMGVVPGIKPPDFPVVSGDFFSYADREDHYWTGYYT 509

  Fly   485 SRPYHKRMDRVLMHYVRAAEMLSAW---HSWDGMARIEER--------LEQARRELSLFQHHDGI 538
            |||::|.|||||..::|.||:|.:.   |:  ..|..|.:        |..|||.|.||||||.|
 Frog   510 SRPFYKSMDRVLESHLRGAEILYSLAINHA--RKAGTESKYPLSDYALLTDARRNLGLFQHHDAI 572

  Fly   539 TGTAKTHVVVDYEQRMQEAL-KACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVED 602
            |||||..||:||..|:..:| ...::::..:.|.::.....|..|.|..:|:.|:||
 Frog   573 TGTAKEAVVIDYGVRLLHSLMNLKRIIINAAHYLVVADKEKYHYDHSVPFFSTDESR-------- 629

  Fly   603 SRTTIILGEDILPSK----------HVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVS 657
                  |.::.||.|          :||:.|.:...|..:|...|::..|.|......||.||:|
 Frog   630 ------LTQESLPEKTVIKLTASPRYVVVFNPVEQNRLCVVSLLVNTYNVRVLTEDGQPVAAQLS 688

  Fly   658 PVWSWHHDTLTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTIS-DSKPEHTSYASNLLLRKNPT 721
            |||....|     ::|.    .|::.|.||:|.:||:.:.|..| |:   ||:..||:.:..:..
 Frog   689 PVWQSVTD-----MNPD----VYQVSFTARLPSLGLSIFQLHASIDT---HTTLKSNVRVHLHGR 741

  Fly   722 SLPLGQ---YPEDVKFGDPREISLRVGN--------GPTLAFSEQGLLKSIQLTQDSPHVPVHFK 775
            .|.:.:   :|  ||..:.......:.|        |.|      ||||||:...:.....::.:
 Frog   742 ELSIKKQDVFP--VKVAESSTDDFHIENQYMQVWFSGTT------GLLKSIKRAGEEQEQKINMQ 798

  Fly   776 FLKYGVRSHGDRSGAYLFLPNGPASP-VELGQPVVLVTKGKLESSVSVGLPSVVHQTIMR----- 834
            ||.||.|:..|:||||||||:|.|.| .....|||.||:|...|.|:.....|  |.:||
 Frog   799 FLIYGTRTSKDKSGAYLFLPDGEAKPYTPKDPPVVKVTEGPFYSEVTCQYQHV--QQVMRLYNLP 861

  Fly   835 ---GGAPEIRNLVDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQ 876
               |.:.:|.:|:||....|.||.|||.|.|.|.|||:|||||.|
 Frog   862 GTEGLSLDISSLIDIRDHVNKEIAMRLSTDIQSEDIFFTDLNGFQ 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	193/344 (56%)
		Alpha-mann_mid	478..554	CDD:214875	43/86 (50%)
		Glyco_hydro_38C	744..1103	CDD:285047	61/150 (41%)
man2a2	NP_001006777.1	PLN02701	128..>906	CDD:178304	361/818 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	431	1.000	Domainoid score	I582
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55954
Inparanoid	1	1.050	765	1.000	Inparanoid score	I541
OMA	1	1.010	-	-		QHG55783
OrthoDB	1	1.010	-	-		D1101882at2759
OrthoFinder	1	1.000	-	-		FOG0002281
OrthoInspector	1	1.000	-	-		otm49416
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2015
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080