Protein Alignment alpha-Man-IIa and alpha-Man-IIb

DIOPT Version :9

• Sequence 1: NP_001262413.1
• Gene: alpha-Man-IIa / 41126
• FlyBaseID: FBgn0011740
• Length: 1109
• Species: Drosophila melanogaster
• Sequence 2: NP_001262614.1
• Gene: alpha-Man-IIb / 41913
• FlyBaseID: FBgn0026616
• Length: 1249
• Species: Drosophila melanogaster
• Alignment Length: 1294
• Identity: 370/1294 - (28%)
• Similarity: 594/1294 - (45%)
• Gaps: 268/1294 - (20%)

  Fly    13 CSGCLLVFLSLYIILNFAAPAATQIKQPNYENIENK---------------------------LH 50
            |.|.|..|:::.:.|.:.:     |.|||...|...                           :|
  Fly    13 CIGLLSAFVTILLCLYYIS-----IGQPNPTPISETGAPSAALRGSPLSGLTGFSVDGGSSSIIH 72

  Fly    51 ELENGLQEHGEEMRNLRARLAETSNRDDPIRPPLKVARSPRPGQCQDVVQDVPNVDVQMLELYDR 115
            :.:..|.....:.::...:.|:||...:. :...:...|....:|.:::|.  |.::...|.:.:
  Fly    73 QQKQQLVIASNQKKSSETKSAQTSVSPEE-QSEEQYTNSNWGDKCYELIQS--NTNITASEEHSK 134

  Fly   116 MSF-------KDIDGGVWKQGWNIKYDPLKYNAHH-KLKVFVVPHSHNDPGWIQTFEEYYQHDTK 172
            ..|       |:    .|.:|:..::|..|.:... .||:.|||||||||||::||..|:|.|::
  Fly   135 FDFQPEWMRSKE----YWDRGFEERFDAQKKDKQRPPLKIIVVPHSHNDPGWLKTFTNYFQSDSR 195

  Fly   173 HILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANS 237
            .||:..:..:.:..:|.|||:|||:...::......|:..:|.::..|::|..||||||.||||.
  Fly   196 QILNLLVTKMQEYTDMTFIWSEISFLQLWWDQAHPTKQRALKRLIDAGRIEITTGGWVMTDEANV 260

  Fly   238 HWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELA 302
            |...:|.||.||..|||..:||||...|:||||||..|:||:|..:.|:..:|||.||:.|:..|
  Fly   261 HIYPMLDQLIEGHQWLKNNLNVTPKVGWSIDPFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFA 325

  Fly   303 QQRQLEFLWRQIWDNKGDT-----ALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCP 362
            :|:..:|:|:..|.::.|.     :|.||.|||..|.|..:|||.|.:|..|||:::.  |....
  Fly   326 RQQSGDFIWKPYWRSRKDKDSEAGSLLTHNMPFDIYSIKGSCGPHPFICLNFDFRKIP--GEYTE 388

  Fly   363 WKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEH 427
            :.|..:.|:|.|:.:::.||::|:.:.|.|:..||.|||:|||||:.::.|.|.|..||::|.:|
  Fly   389 YSVKAQFITDDNLESKAQLLLEQYARTASLFPHNVALIPVGDDFRYNKDREVDQQYQNYKKLIDH 453

  Fly   428 INSQAH-FNVQAQFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDN----YWSGYYTSRP 487
            |.:... :|...:|||..:||:|:.:..:.....|||..||||.|:|....    |||||:|:||
  Fly   454 IMANRRLYNADIRFGTPSDYFEAIKERMKDHTPGFPTFKGDFFVYSDIFSEGRPAYWSGYFTTRP 518

  Fly   488 YHKRMDRVLMHYVRAAEML-SAWHSWDGMARIE----------ERLEQARRELSLFQHHDGITGT 541
            ::|.:...|.|.:|:||:: :..::....|:.|          |.:..|||.|.||||||.||||
  Fly   519 FYKLLSSELEHQLRSAEIVFTLAYNTARQAKRENAIKIYEKNYELIINARRNLGLFQHHDAITGT 583

  Fly   542 AKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDD-SRWP-------GS 598
            :|..|:.||..|:.|:.:....:.:..:..||.|.......|..|.|..|: ::.|       .:
  Fly   584 SKAAVMRDYAMRLFESTQNMVKMQESCLELLLQKGQPRHHGFLLSEFERDNFNKLPRKMPIQMAN 648

  Fly   599 GVEDSRTTIILGEDILPSK-------HVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVE--- 653
            | ::|..|:..||......       ..|::|:|...|.::|...|..|.|.:.:  :..||
  Fly   649 G-DESTPTVPAGEGGAGGSSSSGSVGSFVLYNSLAQKRLEVVTLRVQHPNVKIVN--DKGVELNH 710

  Fly   654 AQVSPVWSWHHDTLTKTIHPQG--------------STTKYRIIFKARVPPMGLATY-------- 696
            .|::|||:     :|.| :.||              ||.::.::|.|.:.|:.|:||
  Fly   711 IQINPVWN-----ITDT-YEQGLGTSVSGTVGRIRTSTRQFEVMFVAELEPLSLSTYRVQVDEVN 769

  Fly   697 ----VLTI-----SDSKPEHTSYASNLLLRKNPTSL------PLGQYPEDVKFGDPREISLRVGN 746
                :.||     ::|:|...|....  :..:|||:      |.|    |::..:|.   :|
  Fly   770 FKRNIATIYCDDCTESQPASVSPPEE--IESSPTSVFEARGKPAG----DIQLENPH---MR--- 822

  Fly   747 GPTLAFSEQ-GLLKSIQLTQDSPHV--PV--HFKFLKYGVRSHGDRSGAYLFLPNGPASPVELGQ 806
               |.|.|: |.||:|........:  |:  :.||..|  ||....||||||..:...|..|  :
  Fly   823 ---LLFDEKSGFLKTITRKNQKKELLKPLQCNIKFAAY--RSAQFHSGAYLFKTDPEQSEAE--K 880

  Fly   807 PV--------VLVTKGKLESSVSV--GLPSVVHQTIM------RGGAPEIRNLVDI---GSLDNT 852
            .|        :::|.|.:.|.|:|  | |.:.|...:      ...|..:.|.:|.   .....|
  Fly   881 EVLEGYTDMRIIITSGPIASDVTVIYG-PFLAHTVRIFNTRTHLDAAIYVENDIDFEPPPKNRET 944

  Fly   853 EIVMRLETHIDS----------------------GDIFYTDLNGLQFIKRRRLDKLPLQANYYPI 895
            |:.||..|:||:                      ..:||:|.||.|:.:|.::..:.::.||:||
  Fly   945 ELFMRFVTNIDNIAQAPMQRDPLKEPVDAATMPELPVFYSDQNGFQYHERIKVPAIGIEGNYFPI 1009

  Fly   896 PSGMFIEDANTRLTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVL 960
            .||.||:|:..||||||....|.:|...|:||:|.|||...||.||:|:||:|::...|.:.|::
  Fly  1010 TSGAFIQDSRLRLTLLTTHAQGAASYEPGQLEVMLDRRTLYDDYRGMGEGVVDSRLTRHKFWLLV 1074

  Fly   961 EKVNNCVRPSELH---PAGY--LTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDHPSARED 1020
            |.:     |...|   |..|  |:..|.:.:.:|..|.:.:..:..|           .|.....
  Fly  1075 EDL-----PGGQHVTQPPSYKVLSQQAQQLANALRYPPNLYFVSNLE-----------QPELAAA 1123

  Fly  1021 LDVSVMRRLTKSSAKTQRVGYVLHRTNLMQCGTPE------------EHTQKLD----------- 1062
            | :.::|.|.|......     :|.|.|.....||            .|.|..|
  Fly  1124 L-LPLVRLLPKGPLPCD-----VHLTTLRTLSDPELQLFPSASALLVLHRQGFDCSVSAGRELSM 1182

  Fly  1063 --VCHL----LPNVA-------RCERTTLTFLQNLE-----HLDGMVAPEVCPMETAAY 1103
              :|.|    |.||.       ..|.|:||..:...     |:..:....:.|||...:
  Fly  1183 EAICPLSSKGLGNVQLGRLSLHTIEATSLTGTEQKSSRESYHIRSLAEISLEPMELRTF 1241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	142/348 (41%)
		Alpha-mann_mid	478..554	CDD:214875	35/86 (41%)
		Glyco_hydro_38C	744..1103	CDD:285047	117/450 (26%)
alpha-Man-IIb	NP_001262614.1	PLN02701	148..1246	CDD:178304	348/1147 (30%)
		GH38N_AMII_GMII_SfManIII_like	167..514	CDD:212120	142/348 (41%)
		Alpha-mann_mid	508..596	CDD:286360	35/87 (40%)
		Glyco_hydro_38C	813..1241	CDD:285047	120/463 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450130
Domainoid	1	1.000	50	1.000	Domainoid score	I680
eggNOG	1	0.900	-	-		E1_KOG1959
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	49	1.000	Inparanoid score	I462
Isobase	1	0.950	-	0	Normalized mean entropy	S4542
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1101882at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102728
Panther	1	1.100	-	-	P	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.750