DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIa and MAN2A1

DIOPT Version :9

Sequence 1:	NP_001262413.1	Gene:	alpha-Man-IIa / 41126	FlyBaseID:	FBgn0011740	Length:	1109	Species:	Drosophila melanogaster
Sequence 2:	NP_002363.2	Gene:	MAN2A1 / 4124	HGNCID:	6824	Length:	1144	Species:	Homo sapiens

Alignment Length:	1206	Identity:	471/1206 - (39%)
Similarity:	667/1206 - (55%)	Gaps:	171/1206 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LRIRRRFAL----VICSGCLLVFLSLYIIL---NFAAPAATQIKQPNYEN---------IENKLH 50
            :::.|:|.:    :.|    :|..|||::|   :...|     :.|..|.         ::.|:.
Human     1 MKLSRQFTVFGSAIFC----VVIFSLYLMLDRGHLDYP-----RNPRREGSFPQGQLSMLQEKID 56

  Fly    51 ELENGLQEHGEEMRNLRARLAETSN--RDDPIRP-------------PLKVARSPRPGQCQDVVQ 100
            .||..|.|:.|.:.|:|..:...|.  .|.|...             |.:::.|.....|....|
Human    57 HLERLLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFASQ 121

  Fly   101 D-VPNVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFE 164
            . ..|.|||||::|..:||.:.||||||||::|.|:..:::. ..|:|||||||||||||::||.
Human   122 SGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDT-EPLQVFVVPHSHNDPGWLKTFN 185

  Fly   165 EYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGW 229
            :|::..|::|.:|.:..|.::...||||:||||.::::..:...||..:||:::|||||.|||||
Human   186 DYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGW 250

  Fly   230 VMPDEANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTH 294
            ||||||..|:..::.||.||..||:..:.|.|.:.||||||||||||.|:|.::|..:|||||.|
Human   251 VMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVH 315

  Fly   295 YSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRM--GSF 357
            |:|||..|..:.|||.|||.||....|.:..|||||||||||||||||||:||||||||:  |.|
Human   316 YAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRF 380

  Fly   358 GLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYE 422
            |  |||.|||.||...||.:|:.:|:||::||::|:||.|||.|||||||:.:.||||:|..||:
Human   381 G--CPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDFRYCEYTEWDLQFKNYQ 443

  Fly   423 RLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERA----GQAEFPTLSGDFFTYADRSDNYWSGYY 483
            :||:::|||:.|.|:.|||||.::|||:.:|:..    ||:.||.|||||||||||.|:|||||:
Human   444 QLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYF 508

  Fly   484 TSRPYHKRMDRVLMHYVRAAEMLSAW-----HSWDGMARIEE--------RLEQARRELSLFQHH 535
            ||||::|||||::..::||||:|..:     |.:    :|.:        .|.:|||.|.|||||
Human   509 TSRPFYKRMDRIMESHLRAAEILYYFALRQAHKY----KINKFLSSSLYTALTEARRNLGLFQHH 569

  Fly   536 DGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTKPSI----YSPDFSFSYFTLDDSRWP 596
            |.||||||..|||||..|:..:|...:.::..|.:.|:.|..:    ||||   ::..:|..:
Human   570 DAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLILKDKLTYDSYSPD---TFLEMDLKQ-- 629

  Fly   597 GSGVEDSRTTIILGEDILPSKHV----------VMHNTLPHWREQLVDFYVSSPFVSVTDLANNP 651
                        ..:|.||.|::          |::|.|...|..||..|||||.|.|...:..|
Human   630 ------------KSQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSVYVSSPTVQVFSASGKP 682

  Fly   652 VEAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLL 716
            ||.|||.||    || ..||    |.|.|.|.|:|.:||:||..|.:..|.|.   .|:.::.:|
Human   683 VEVQVSAVW----DT-ANTI----SETAYEISFRAHIPPLGLKVYKILESASS---NSHLADYVL 735

  Fly   717 RKNPTSLPLGQYPED-----VKFGDPREISLRVGNG-PTLAFSEQGLLKSIQLTQDSPHVPVHFK 775
            .||..        ||     :|.....|..:.:.|. ..|.|.:.||:|.:...:|..|..|:.:
Human   736 YKNKV--------EDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMTKEDGKHHEVNVQ 792

  Fly   776 FLKYGVRSHGDRSGAYLFLPNGPASP-VELGQPVVLVTKGKLESSVSVGLPSVVHQTIM------ 833
            |..||.....|:||||||||:|.|.| |....|.|.||.|::.|.|:.....|.|:..:
Human   793 FSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTCFFDHVTHRVRLYHIQGI 857

  Fly   834 RGGAPEIRNLVDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSG 898
            .|.:.|:.|:|||..:.|.||.|::.:.|.|.:.|||||||.|...|..|.|||||||.||:.:.
Human   858 EGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQIQPRMTLSKLPLQANVYPMTTM 922

  Fly   899 MFIEDANTRLTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKV 963
            .:|:||..|||||:.|.||.|||.||::|::.||||..||.|||.||:.|||...:::|::|||.
Human   923 AYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNKITANLFRILLEKR 987

  Fly   964 NNCVRPSELHPAGYLTSAAHKASQSLLDPL----DKFIFAENEWIGAQGQFGGDHPSAREDLDVS 1024
            :......|.....|.:..:|..|..:..|:    :||   .:..:..||:|.....|...|:.:.
Human   988 SAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPMANKF---SSPTLELQGEFSPLQSSLPCDIHLV 1049

  Fly  1025 VMRRLTK--SSAKTQRVGYVLHR-----------TNLMQCGTPEEHTQKLDVCHLLPNVARCERT 1076
            .:|.:..  .:..:.....:|||           |.|. |.|    ||...:...|.|....|..
Human  1050 NLRTIQSKVGNGHSNEAALILHRKGFDCRFSSKGTGLF-CST----TQGKILVQKLLNKFIVESL 1109

  Fly  1077 TLTFL---------QNLEHLDGMVAPEVCPMETAAY 1103
            |.:.|         ||:..::      :.|||.:.:
Human  1110 TPSSLSLMHSPPGTQNISEIN------LSPMEISTF 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	195/344 (57%)
		Alpha-mann_mid	478..554	CDD:214875	43/88 (49%)
		Glyco_hydro_38C	744..1103	CDD:285047	132/392 (34%)
MAN2A1	NP_002363.2	PLN02701	128..1144	CDD:178304	444/1070 (41%)
		GH38N_Man2A1	165..508	CDD:212131	195/344 (57%)
		Alpha-mann_mid	503..588	CDD:214875	43/88 (49%)
		Glyco_hydro_38C	754..1139	CDD:285047	133/398 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147920
Domainoid	1	1.000	424	1.000	Domainoid score	I614
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	758	1.000	Inparanoid score	I553
Isobase	1	0.950	-	0	Normalized mean entropy	S4542
OMA	1	1.010	-	-		QHG55783
OrthoDB	1	1.010	-	-		D1101882at2759
OrthoFinder	1	1.000	-	-		FOG0002281
OrthoInspector	1	1.000	-	-		otm42189
orthoMCL	1	0.900	-	-		OOG6_102728
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3970
SonicParanoid	1	1.000	-	-		X2015
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.650