Protein Alignment alpha-Man-IIa and Man2b2

DIOPT Version :10

• Sequence 1: NP_001262413.1
• Gene: alpha-Man-IIa / 41126
• FlyBaseID: FBgn0011740
• Length: 1109
• Species: Drosophila melanogaster
• Sequence 2: NP_001128443.2
• Gene: Man2b2 / 360955
• RGDID: 1308840
• Length: 1004
• Species: Rattus norvegicus
• Alignment Length: 911
• Identity: 248/911 - (27%)
• Similarity: 388/911 - (42%)
• Gaps: 174/911 - (19%)

  Fly   136 PLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFAR 200
            ||.......::.|||||||.|.||:.|.:|..:....::.:..:..|....:.:||..|..:| |
  Rat    18 PLAARPASPIRAFVVPHSHMDVGWVYTVQESMRAYAANVYTTVVEELVRGRQRRFIAVEQEFF-R 81

  Fly   201 FYHD--LGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFMNVTPTA 263
            .:.|  ..|.:|.|::.::..|:||||.||.||.|||.:|..:.:||||||..:|.:...:.|..
  Rat    82 LWWDGVASEQQKQQVRQLLDEGRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGIRPQF 146

  Fly   264 SWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMM 328
            ||.:||||.|.|.|.:...:||...||.|..|.:|..:.:.:.|:|:|...........::||:|
  Rat   147 SWHVDPFGASATTPTLFALAGFNAHLISRIDYDLKDAMQEAQGLQFVWHGSPSLSEQQEIYTHVM 211

  Fly   329 PFYSYDIPHTCGPDPKVCCQFDFKRMGSF---GLSCPWKVPP--------RTISDQNVAARSDLL 382
            ..|||     |.|.     ...|.....|   |::...:.||        ..::..|:...::.|
  Rat   212 DLYSY-----CTPS-----HIPFSNRSGFYWNGVAVFPEPPPDGVYPNMSEPVTVDNIHLYAEAL 266

  Fly   383 VDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQ-AHFNVQAQFGTLQEY 446
            |...|::|..:||..:|.|.|.|   ||.....||..|.:.|.|:||:: |.|.:..|:.||.:|
  Rat   267 VANVKQRAAWFRTPHVLWPWGCD---KQFFNASVQFDNMDPLLEYINNRSAQFGISVQYATLNDY 328

  Fly   447 FDAVHQAERAGQAEFPTL-----SGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEML 506
            |.|:|        :|...     ..||..|:......|:|::|||...|.:.|.....:.|.|.:
  Rat   329 FQALH--------DFNVTWDIRDHHDFLPYSSEPQQAWTGFFTSRSTLKGLARQASALLYAGESM 385

  Fly   507 SAWHSW-------DGMARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQMV 564
            ...:.|       |....::: |:|.|..:|..||||.||||....|...|.:.:...::
  Rat   386 FTRYMWPHPRGTLDPTWALQQ-LQQLRWAVSEVQHHDAITGTESPKVKNMYMEHLSMGMR----- 444

  Fly   565 MQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSKHVVMHNTLPHWR 629
               .|::|:...::..|              ||||. |:|..         .....::|.|. |:
  Rat   445 ---GVHKLMASIALDRP--------------PGSGT-DTRPV---------GYSASVYNPLA-WK 481

  Fly   630 -EQLVDFYVSSPFVSVTDLANNPVEAQVS-----------------PVWSWHHDTLTKTIHPQGS 676
             ..::...|:.|.|||||....||.||:.                 |..|:.|..:.:|...|..
  Rat   482 ITTIITLTVAFPSVSVTDELGRPVSAQIQNSTKDPSAYDLLILTTIPGLSYRHYKVRRTRGDQAG 546

  Fly   677 TTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREIS 741
            |       :..|.|   ....|..|......||....||       :|:
  Rat   547 T-------RELVTP---RANTLKFSRKLRNQTSQEGKLL-------VPV---------------- 578

  Fly   742 LRVGNGPTLAFSEQ-GLLKSIQLTQDSPHVPVHFKFLKYGVRSHGD-----RSGAYLFLPNGPAS 800
              :.:..||.|.:. .:|.|||..|.:..|.:..:||:|  |::||     .|..|||..|..|.
  Rat   579 --MNDCYTLLFDQDTNMLHSIQDRQSNRTVHMTQEFLEY--RANGDVKQGPISDNYLFASNDTAE 639

  Fly   801 P--VELGQPVVL--------------VTKGKLESSVSVGL----PSVVHQTIMRGGAPEIRNLVD 845
            |  ..:|..:|:              :|......|:...|    ||:..:.:.|    .|.....
  Rat   640 PSWEAVGMEMVVGTLATDVRQYFYRNITDQGYIYSIHTRLAHVHPSLAGELLCR----RIEQQYQ 700

  Fly   846 IGSLD-NTEIVMRLETHIDSGDIFYTDLNGLQFIKR--RRLDKLPLQANYYPIPSGMFIEDANTR 907
            :|.|| |.|.::|..:.::|..:.|:|.||.|..:|  :.....|:..||||:....||||..:|
  Rat   701 VGPLDLNREAILRTSSDLNSQQVLYSDNNGYQMQRRPYKAFKSNPIPRNYYPMVQSAFIEDDKSR 765

  Fly   908 LTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGV-LDNKPVLH-IYRLVL--EKVNNCVR 968
            |.||..:|.|.||..:|::|:|..|||.::....|...: |::..|:| :..|:|  :.....:|
  Rat   766 LVLLAERPHGVSSQENGQVEVMLHRRLWNNLVWDLNYNLTLNDTSVVHPVLWLLLGPKSTTTALR 830

  Fly   969 P 969
            |
  Rat   831 P 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	PLN02701	105..990	CDD:178304	248/911 (27%)
		Glyc_hyd_38C_2	1020..1108	CDD:408054
Man2b2	NP_001128443.2	PLN02701	27..792	CDD:178304	236/861 (27%)
		GH38N_AMII_Epman_like	27..352	CDD:212122	108/346 (31%)