DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIa and LManII

DIOPT Version :9

Sequence 1:	NP_001262413.1	Gene:	alpha-Man-IIa / 41126	FlyBaseID:	FBgn0011740	Length:	1109	Species:	Drosophila melanogaster
Sequence 2:	NP_609408.1	Gene:	LManII / 34437	FlyBaseID:	FBgn0027611	Length:	1080	Species:	Drosophila melanogaster

Alignment Length:	868	Identity:	245/868 - (28%)
Similarity:	384/868 - (44%)	Gaps:	140/868 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 PLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQ-HDTK-------HILSNALRHLHDNPEMKFIW 192
            |.|.|   .|.|.:|.|:|:|.||::|.::||. .:||       :|:.:.:..|..:||.:||:
  Fly    41 PTKPN---MLNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIY 102

  Fly   193 AEISYFARFYHDLGENKKLQ--MKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQ 255
            .|.::|.:::.:  :..|:|  :|.:|:.|:|||:.|.|.|.|||.:|:::|:.|.    :|..:
  Fly   103 VESAFFFKWWKE--QKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQF----SWGLR 161

  Fly   256 FMNVT------PTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQI 314
            .:|.|      |...|.|||||||..|..:..:.||..|...|..|..|.|....:..|.:|...
  Fly   162 LLNDTFGECGRPRVGWQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGS 226

  Fly   315 WDNKGDTA-LFTHMMPFYSYDIPH------TCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISD 372
             .|.|:.| ||:..: :.:|..|.      .|...|.:    |.|..                .|
  Fly   227 -ANLGEEADLFSGAL-YNNYQAPDGFCFDILCNDAPII----DGKHS----------------PD 269

  Fly   373 QNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINS-QAH-FN 435
            .||..|.|..:|..|.:::.||||.:::.:|.||.::..   .|...|.::|..:.|. ||: .|
  Fly   270 NNVKERIDTFLDFAKTQSQYYRTNNIIVTMGGDFTYQAA---QVYYKNLDKLIRYGNERQANGSN 331

  Fly   436 VQAQFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYV 500
            :...:.|...|..::|.|    ...:||.|.|||.||.....||:||:||||..||.:|...|::
  Fly   332 INLLYSTPSCYLKSLHDA----GITWPTKSDDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFL 392

  Fly   501 RAAEMLSAWHSWDGMA-----RIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKA 560
            :..:.|||      :|     ..:..|...|..|.:.||||.||||.|..|.:||.:||..|.:|
  Fly   393 QVCKQLSA------LAPKKPEEFDPHLTFMRETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRA 451

  Fly   561 CQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSKH------V 619
            |....:.::.:|..:......|.|..|            |.:.:|..:|.....|...      :
  Fly   452 CGATTRNALNQLTVQSKDNVKDTSAKY------------VFEFKTCALLNITSCPVSEANDRFAL 504

  Fly   620 VMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIF 684
            .::|.|.|...:.|...|......:.|.....:|:|..|:     ..:...|..:.||.||.|:|
  Fly   505 TLYNPLAHTVNEYVRIPVPYSNYRIIDNKGVTLESQAVPI-----PQVLIDIKHRNSTAKYEIVF 564

  Fly   685 KA-RVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREISLRVGNGP 748
            .| .:|.:|..||.:...||...:|   .:..|.|..:|:.:                  :||..
  Fly   565 LATNIPALGYRTYYVEKLDSTEGNT---RSKALPKRTSSVTV------------------IGNSH 608

  Fly   749 -TLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHGD----RSGAYLFLPNGPASPVELGQPV 808
             .|.|...|.|..:.....:..|...|.|.:..|.::.:    .||||:|.||.........|..
  Fly   609 IQLGFDTNGFLSEVTADGLTRLVSQEFLFYEGAVGNNAEFLNRSSGAYIFRPNENKIHFATDQVE 673

  Fly   809 VLVTKGKLESSVSVGLPSVVHQTIM---RGGAPEIRNLVDIGSLDN---TEIVMRLETHIDSGDI 867
            :.|.||.|...|.......:.|.:.   :....|...||....:|:   .|::.|..:.|.|..|
  Fly   674 IEVYKGDLVHEVHQKFNDWISQVVRVYNKDSYAEFEWLVGPIPIDDGIGKEVITRFNSDIASDGI 738

  Fly   868 FYTDLNGLQFIKRR---------RLDKLPLQANYYPIPSGMFIEDANTRLTLLTGQPLGGSSLAS 923
            |.||.||.:.|||:         :::: .:..|||||.:.:.:||...|:.:||.:..|||||..
  Fly   739 FRTDSNGREMIKRKINHRDTWSVKINE-AVAGNYYPITTKIDVEDDTARMAILTDRAQGGSSLKD 802

  Fly   924 GELEIMQDRRLASDDERGLGQGV 946
            |.||:|..|||..||..|:|:.:
  Fly   803 GSLELMVHRRLLKDDAFGVGEAL 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	107/363 (29%)
		Alpha-mann_mid	478..554	CDD:214875	31/80 (39%)
		Glyco_hydro_38C	744..1103	CDD:285047	67/223 (30%)
LManII	NP_609408.1	GH38N_AMII_LAM_like	47..323	CDD:212121	88/306 (29%)
		Alpha-mann_mid	370..445	CDD:214875	31/80 (39%)
		Glyco_hydro_38C	502..957	CDD:285047	94/351 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450137
Domainoid	1	1.000	50	1.000	Domainoid score	I680
eggNOG	1	0.900	-	-		E1_KOG1959
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	49	1.000	Inparanoid score	I462
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3970
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.820