DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIa and LManIV

DIOPT Version :9

Sequence 1:	NP_001262413.1	Gene:	alpha-Man-IIa / 41126	FlyBaseID:	FBgn0011740	Length:	1109	Species:	Drosophila melanogaster
Sequence 2:	NP_609251.2	Gene:	LManIV / 34204	FlyBaseID:	FBgn0032067	Length:	978	Species:	Drosophila melanogaster

Alignment Length:	891	Identity:	237/891 - (26%)
Similarity:	394/891 - (44%)	Gaps:	200/891 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 YDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEE-YYQHDTK-------HILSNALRHLHDNPEMKF 190
            |:.......:.:.:.:|||||||.||::|.:: ||.:..|       :||.:.:..|..:|:.:|
  Fly    27 YESCPETKANMVNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAGVQYILDSVVSQLLQDPKRRF 91

  Fly   191 IWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQ 255
            |..|.::||::::...|:.|..:..:|..|:.||..|.|.|.||||.:::.|:.|.|.|   ||
  Fly    92 IQVETAFFAKWWNVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEANVNYQGVIDQFTVG---LK- 152

  Fly   256 FMNVT------PTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQI 314
            |:|.|      |...|.||.||||.....|....|:......|..::.|........:|.:| ..
  Fly   153 FLNETFGSCGRPRVGWQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKDTRMNDLTMEMIW-DA 216

  Fly   315 WDNKGDTALFTHMM-PFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQ----- 373
            .::....:||:.|: .||| |.|..|                 |.:.|         :||
  Fly   217 SESMSGVSLFSGMLYNFYS-DTPGFC-----------------FDILC---------TDQPIIDG 254

  Fly   374 -----NVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNY---ERLFEHIN- 429
                 ||..|.|..:...|..:|:|.||.:::|:|.||:::.      .:|||   ::|.::||
  Fly   255 DSEENNVKQRVDDFISYAKNVSEVYITNHIMVPMGGDFQYED------AKVNYKNMDKLIKYINE 313

  Fly   430 ---SQAHFNVQAQFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKR 491
               |.:.:|:  .:.|...|.:::||:..:    :|..:.|||.||...:::|:|::||||..||
  Fly   314 RQASGSKYNI--FYSTPSCYLNSLHQSLES----WPNKTQDFFPYAHEKNSFWTGFFTSRPTQKR 372

  Fly   492 MDRVLMHYVRAAEMLSAWHSWDGMARI--EER---LEQARRELSLFQHHDGITGTAKTHVVVDYE 551
            .:|...|.::.|:.||.      :|.:  ||.   |:..|:.:.:.||||.||||.|..|..||:
  Fly   373 FERDGNHMLQVAKQLSV------LANLTSEEHKIDLDYLRQVMGVMQHHDAITGTEKQAVSDDYD 431

  Fly   552 QRMQEALKACQMVMQQSVYRLLTK------PSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILG 610
            :.|.||:.......:.:: ||||.      .|....:.|...||.|.:
  Fly   432 RMMYEAIVGASNNARDAL-RLLTNMPYGEFESCLRLNISECAFTKDGA----------------- 478

  Fly   611 EDILPSKHVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQG 675
            :::|    |.::|.|.|...|.|...|......|||.....|.::|.|| .|.    ...:..:.
  Fly   479 DNVL----VTLYNPLAHSSTQYVRIPVKEENYQVTDEKGRTVPSEVVPV-PWQ----VLALEYRS 534

  Fly   676 STTKYRIIFKARVPPMGLATY-VLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPRE 739
            :.|::.::|||.|..  :::| :..:..|:.:|:|                      :|..:|||
  Fly   535 NDTQHELVFKATVNK--VSSYSIKKVESSEVKHSS----------------------IKKINPRE 575

  Fly   740 ISLRVGNGPTLA---------FSEQGLLKSIQLTQDSPHVPVHFKFLKYGV-RSHGDRSGAYLFL 794
            .:    |..|:.         .:..|.|||:::...|..:..:|     || :||  .|.||.|.
  Fly   576 DN----NSETVVENSVVKLVMDNHTGRLKSVEMNGVSEKIVQNF-----GVYKSH--TSCAYTFR 629

  Fly   795 PNGPASPVELGQPVVLVTKGKLESSVSVG-LPSVVHQTIMRGGAPEIRNLVDIGSLD-------- 850
            .:|   .:||       .:...|.:|..| |...|||.:....:..||....:..::
  Fly   630 QDG---DIEL-------FENDFEFTVYEGSLVKEVHQHVNDWISQVIRIYEGVSRVELEWMVGPI 684

  Fly   851 ------NTEIVMRLETHIDSGDIFYTDLNGLQFIKRRR---------LDKLPLQANYYPIPSGMF 900
                  .:|.|...::.|.|..:||||.||.:.:||.:         |.:.|:..|:||:.|.:.
  Fly   685 PIDDKLGSEFVTNFKSEISSNGVFYTDSNGRELMKRVKDKREDFVSDLSRQPVSGNFYPVTSRIA 749

  Fly   901 IEDANTRLTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGV 946
            ::|...||.||..:..||:||..|.||::..||...:|..|:|:.:
  Fly   750 LQDDTKRLVLLNDRSQGGASLEDGALEMLIHRRHLFNDGGGVGEAL 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	104/370 (28%)
		Alpha-mann_mid	478..554	CDD:214875	30/80 (38%)
		Glyco_hydro_38C	744..1103	CDD:285047	63/237 (27%)
LManIV	NP_609251.2	GH38N_AMII_LAM_like	39..312	CDD:212121	88/310 (28%)
		Alpha-mann_mid	359..434	CDD:214875	30/80 (38%)
		Glyco_hydro_38C	483..973	CDD:285047	91/363 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450139
Domainoid	1	1.000	50	1.000	Domainoid score	I680
eggNOG	1	0.900	-	-		E1_KOG1959
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	49	1.000	Inparanoid score	I462
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.790