DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Man-IIa and Man2a1

DIOPT Version :9

Sequence 1:NP_001262413.1 Gene:alpha-Man-IIa / 41126 FlyBaseID:FBgn0011740 Length:1109 Species:Drosophila melanogaster
Sequence 2:NP_037111.2 Gene:Man2a1 / 25478 RGDID:3038 Length:1148 Species:Rattus norvegicus


Alignment Length:1162 Identity:462/1162 - (39%)
Similarity:657/1162 - (56%) Gaps:145/1162 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 LRIRRRFAL----VICSGCLLVFLSLYIIL---NFAAPAATQ----IKQPNYENIENKLHELENG 55
            :::.|:|.:    :.|    :|..|||::|   :...|...:    ..|.....::.|:..||..
  Rat     1 MKLSRQFTVFGSAIFC----VVIFSLYLMLDRGHLDYPRGPRQEGSFPQGQLSILQEKIDHLERL 61

  Fly    56 LQEHGEEMRNLRARLAETSN--RDDPIRP------------PLKVARSPRPGQCQDVVQD-VPNV 105
            |.|:.|.:.|:|..:...|.  .|.|..|            ..::|....|..|....|. ..:.
  Rat    62 LAENNEIISNIRDSVINLSESVEDGPRGPAGNASQGSAHLHSAQLALQADPKDCLFASQSGNQHR 126

  Fly   106 DVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHD 170
            |||||::||.:.|.:.||||||||::|||:..::: ...|:|||||||||||||::||.:|::..
  Rat   127 DVQMLDVYDLIPFDNPDGGVWKQGFDIKYEADEWD-REPLQVFVVPHSHNDPGWLKTFNDYFRDK 190

  Fly   171 TKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEA 235
            |::|.:|.:..|.::...||||:||||.|:::..:...||..:||:::|||||.|||||||.|||
  Rat   191 TQYIFNNMVLKLKEDSSRKFIWSEISYLAKWWDIIDNPKKEAVKSLLQNGQLEIVTGGWVMADEA 255

  Fly   236 NSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKE 300
            .:|:..::.||.||..||::.:.|.|.:.||||||||||||.|:|:::||.:|||||.||||||.
  Rat   256 TTHYFALIDQLIEGHQWLEKNLGVKPRSGWAIDPFGHSPTMTYLLKRAGFSHMLIQRVHYSVKKH 320

  Fly   301 LAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRM--GSFGLSCPW 363
            .:.|:.|||.|||.||....|.:..|||||||||||||||||||:||||||||:  |.:|  |||
  Rat   321 FSLQKTLEFFWRQNWDLGSTTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRYG--CPW 383

  Fly   364 KVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHI 428
            .|||..||..||.:|:.:|:||::||::|:||.|||.||||||||.:.||||:|..|||:||.::
  Rat   384 GVPPEAISPGNVQSRAQMLLDQYRKKSKLFRTKVLLAPLGDDFRFSEYTEWDLQYRNYEQLFSYM 448

  Fly   429 NSQAHFNVQAQFGTLQEYFDAVHQA----ERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYH 489
            |||.|..|:.|||||.:||||:.::    ::.||:.||.|||||||||||.|:|||||:||||::
  Rat   449 NSQPHLKVKIQFGTLSDYFDALEKSVAAEKKGGQSVFPALSGDFFTYADRDDHYWSGYFTSRPFY 513

  Fly   490 KRMDRVLMHYVRAAEMLSAWHSWDGMA---RIEE--------RLEQARRELSLFQHHDGITGTAK 543
            |||||::...:|.||:|  :|.....|   :|.:        .|.:|||.|.||||||.||||||
  Rat   514 KRMDRIMESRLRTAEIL--YHLALKQAQKYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAK 576

  Fly   544 THVVVDYEQRMQEALKACQMVMQQSVYRLLTK-PSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTI 607
            ..|||||..|:.::|.:.:.::..|.:.|:.| ..:|..|.|.::..:|..:             
  Rat   577 DWVVVDYGTRLFQSLNSLEKIIGDSAFLLILKDKKLYQSDPSKAFLEMDTKQ------------- 628

  Fly   608 ILGEDILPSKHV-----------VMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWS 661
             ..:|.||.|::           |::|.....|..:|...|:|..|.|.......||.|||.||.
  Rat   629 -SSQDSLPKKNIIQLSAQEPRYLVVYNPFEQERHSVVSVRVNSATVKVLSDLGKAVEVQVSAVWK 692

  Fly   662 WHHDTLTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLG 726
            ....|         |...|.:.|.|.:||:||..|.:..|.|.   :|:.::..|..|......|
  Rat   693 DMRTT---------SQAAYEVAFLAHLPPLGLKVYKILESQSS---SSHLADYFLYNNDGQAESG 745

  Fly   727 QY--PEDVKFGDPREISLRVGNG-PTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHGDRS 788
            .:  ...|..||    ::.:.|. .||.|...||::.::..:|:....:..:||.||..:..|:|
  Rat   746 IFHMKNMVDSGD----AITIENSFLTLGFDRSGLMEKVRRKEDNKQQELKVQFLWYGTTNKRDKS 806

  Fly   789 GAYLFLPNGPASP-VELGQPVVLVTKGKLESSVSVGLPSVVHQTIM------RGGAPEIRNLVDI 846
            |||||||:|...| |.|..|.|.||:|::.|.|:..|..|.|:..:      .|.:.|:.|:|||
  Rat   807 GAYLFLPDGQGQPYVSLRTPFVRVTRGRIYSDVTCFLEHVTHKVRLYHIQGIEGQSMEVSNIVDI 871

  Fly   847 GSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTRLTLL 911
            .|:.|.|||||:.:.|::.:.:||||||.|...||.:.|||||||.||:.:..:|:||..|||||
  Rat   872 RSVHNREIVMRISSKINNQNRYYTDLNGYQIQPRRTMAKLPLQANVYPMSTMAYIQDAAHRLTLL 936

  Fly   912 TGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNC-VRPSELHPA 975
            :.|.||.||:|||::|:..||||..||.|||||||.|||...:::|::|||.|.. :...:..|.
  Rat   937 SAQSLGASSMASGQIEVFMDRRLMQDDNRGLGQGVHDNKITANLFRILLEKRNGMNMEEDKKSPV 1001

  Fly   976 GYLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDHPSAREDLDVSVMRRLTKS-------- 1032
            .|.:..:|..|..|..|....:.:            |..||...:| :|..|.|..|        
  Rat  1002 SYPSLLSHMTSAFLNHPFLPMVLS------------GQLPSPAIEL-LSEFRLLQSSLPCDIHLV 1053

  Fly  1033 SAKT--QRVG--------YVLHRTNLMQC-------GTPEEHTQ-KLDVCHLLPNVA 1071
            :.:|  .:||        .:||| .:..|       |.|...|| |:.:..|..|.|
  Rat  1054 NLRTIQSKVGKGYSDEAALILHR-KVFDCQLSSRAMGLPCSTTQGKMSIPKLFNNFA 1109

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Man-IIaNP_001262413.1 GH38N_AMII_GMII_SfManIII_like 144..483 CDD:212120 198/344 (58%)
Alpha-mann_mid 478..554 CDD:214875 43/86 (50%)
Glyco_hydro_38C 744..1103 CDD:285047 133/363 (37%)
Man2a1NP_037111.2 PLN02701 127..1148 CDD:178304 436/1032 (42%)
GH38N_Man2A1 164..507 CDD:212131 198/344 (58%)
Alpha-mann_mid 502..587 CDD:214875 43/86 (50%)
Glyco_hydro_38C 733..1142 CDD:285047 139/395 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1121..1148
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166341790
Domainoid 1 1.000 426 1.000 Domainoid score I586
eggNOG 1 0.900 - - E1_KOG1959
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 766 1.000 Inparanoid score I516
OMA 1 1.010 - - QHG55783
OrthoDB 1 1.010 - - D1101882at2759
OrthoFinder 1 1.000 - - FOG0002281
OrthoInspector 1 1.000 - - otm46338
orthoMCL 1 0.900 - - OOG6_102728
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2015
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.670

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