DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIa and ams1

DIOPT Version :9

Sequence 1:	NP_001262413.1	Gene:	alpha-Man-IIa / 41126	FlyBaseID:	FBgn0011740	Length:	1109	Species:	Drosophila melanogaster
Sequence 2:	NP_593979.1	Gene:	ams1 / 2543485	PomBaseID:	SPAC513.05	Length:	1077	Species:	Schizosaccharomyces pombe

Alignment Length:	906	Identity:	176/906 - (19%)
Similarity:	309/906 - (34%)	Gaps:	276/906 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 KLKVFVVPHSHNDPGWIQTFEE------------------YYQHDTKHILSNALRHL---HDNPE 187
            |..||.:.|.|.|..|:..|.|                  |.::  :.:.|.||::|   .|:|:
pombe   280 KANVFAIGHCHIDTAWLWPFAETRRKIVRSWATQMNIMDRYPEY--QFVCSQALQYLWLKEDHPD 342

  Fly   188 MKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTW 252
            :         |.:....:.:||.:.            :.|.||..|....:..:::.|...||.:
pombe   343 V---------FEKLKEYVNQNKFIP------------IGGSWVEHDTNIPNGESLIRQFLLGQHF 386

  Fly   253 LKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQI--- 314
            .::...|.....|..|.||:|..:|.|.:..|....|.|:                ..|..|
pombe   387 FEKEFGVRCRTFWLPDTFGYSSQIPQICRLCGMDRFLTQK----------------LSWNNINSF 435

  Fly   315 ------WDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQ 373
                  |.....:.:..||.|..:|                                    .:|.
pombe   436 PTSTFNWVALDGSQVICHMPPANTY------------------------------------TADT 464

  Fly   374 NVAARSDLL--VDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNV 436
            ||   :|:|  :||.|.... .:..:|:..:||.     ......:.:...|..:.|.:...:..
pombe   465 NV---NDVLHSIDQHKNLVN-DQAGLLVFGIGDG-----GGGPTPEMLEKLRRCKGIANTVGYLP 520

  Fly   437 QAQFG-TLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDR---VLM 497
            ..:.| |:.|:||.:.:...|||. .|:.:|:.:.      .:..|.||::...|::.|   :.:
pombe   521 NVKLGNTVDEFFDGILKRTNAGQT-LPSWNGELYF------EFHRGTYTTQAELKKLMRKVEIAL 578

  Fly   498 HYVRAAEMLSAWHSWDGMARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQ 562
            |.......|::..|.| .:..:|.|:...|:..|.|.||.:.|:....|..|....|.:.||..:
pombe   579 HDAEYVSTLASIFSKD-YSYPKESLQDLWRDTLLCQFHDVLPGSCIEMVYKDAIPIMSKVLKNTE 642

  Fly   563 MVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGV--EDSRTTIIL-----GEDILPSKHVV 620
            .::.|::.:|..|.: .|.|.......|:...|...||  |.....::.     |:.||.:.|..
pombe   643 ALLWQAIEQLGFKKA-SSSDNKEQLCLLNTLPWNVRGVITETEENKLVYFESCDGKGILTAAHTS 706

  Fly   621 MHNTLPHWREQ----LVDFYV------SSPFVSVTDL-----------------ANNPVEAQVSP 658
            :.:....:::.    ||:.::      :...:|:.||                 ||..|..:.:|
pombe   707 LKHPAAAYQKDDNFILVNDHLRVTIAPNGLILSLFDLHKEREILDLKSGKNHAGANQYVLFEDTP 771

  Fly   659 V-W-SWHHDTLTKTIHPQGSTTKYRIIFKARV----------------PPMGLATYVLTIS---- 701
            : | :|..:..        |..||.::.|.:|                |...|:....|||
pombe   772 LSWQAWDTEVF--------SLEKYEVLDKGKVSIKESGPLRASVVVDIPISELSHMKATISLEGY 828

  Fly   702 ------------------------------DSKPEHTSYASNLLLRKNP----TSLPLGQYPEDV 732
                                          |...|..||.:...:.|.|    ||..:.::  :|
pombe   829 NDCSEFTGVNFTCEVDWHESCKFLKVEFPVDIHSEFASYETQFGITKRPTHYNTSWDVAKF--EV 891

  Fly   733 ---KFGDPREISLRVG--NGPTLAFSEQGLLKSIQL----TQDSPHVPVHFKFLKYGVRSHG--- 785
               ||.|..:.:..|.  |.....||..|.|..:.|    .|...|..:....::|.|..|.
pombe   892 CHQKFADYSDFTYGVSVLNDCKYGFSTHGNLMRLSLLRSPKQPDAHADMGKHTIRYAVYPHSKPL 956

  Fly   786 DRS---GAYLFLPNGPASPVELGQPVVLVTKGKLESSVS-------VGLPSVVHQTIM---RGGA 837
            |.|   .|:.|..|           ..|:|:....:::.       ||.|:|:...|.   :|.:
pombe   957 DSSTVRAAHKFNSN-----------FRLLTRASDTANLDIFDAFQLVGEPNVILSHIKMAEKGKS 1010

  Fly   838 PEIRNLVDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKL-PLQAN-YYPIP 896
            ..:|....:|......:|::..|...     .|..|||:    ..|::| .|::| ||.:|
pombe  1011 IILRVYESLGGKSRARLVIKSLTVAS-----VTKCNGLE----EDLEELCTLKSNDYYEVP 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	68/371 (18%)
		Alpha-mann_mid	478..554	CDD:214875	19/78 (24%)
		Glyco_hydro_38C	744..1103	CDD:285047	40/177 (23%)
ams1	NP_593979.1	AMS1	44..1077	CDD:223460	176/906 (19%)
		GH38N_AMII_ScAms1_like	282..538	CDD:212123	61/339 (18%)
		Alpha-mann_mid	555..634	CDD:286360	19/79 (24%)
		Glyco_hydro_38C	664..1073	CDD:285047	82/429 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	60	1.000	Domainoid score	I3021
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3970
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940