Protein Alignment alpha-Man-IIa and aman-2

DIOPT Version :9

• Sequence 1: NP_001262413.1
• Gene: alpha-Man-IIa / 41126
• FlyBaseID: FBgn0011740
• Length: 1109
• Species: Drosophila melanogaster
• Sequence 2: NP_505995.2
• Gene: aman-2 / 179632
• WormBaseID: WBGene00010284
• Length: 1145
• Species: Caenorhabditis elegans
• Alignment Length: 1181
• Identity: 431/1181 - (36%)
• Similarity: 657/1181 - (55%)
• Gaps: 165/1181 - (13%)

  Fly     5 RRRFALVICSGCLLVFLSLYIILNFAAPAATQIKQPNY-ENIENKLHELENGLQEHGEEMRNL-- 66
            :|.|.:::|.|..|. :|||:.......|....|:..| :::..|:..||:..:|:|..:..|
 Worm     3 KRNFYIILCLGVFLT-VSLYLYNGIETGAEALTKRQRYVDDLRRKIGNLEHVAEENGRTIDRLEQ 66

  Fly    67 ---RARLAETSNRDD--------------------PIR---------PPLKVARSPRPGQCQDVV 99
               ||:..::.:.|:                    |:|         ..:|....|.|.. :||.
 Worm    67 EVQRAKAEKSVDFDEEKEKTEEKEVEKEEKEVAPVPVRGNRGEMAHIHQVKQHIKPTPSM-KDVC 130

  Fly   100 QDVPNV-----DVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGW 159
            ....||     |:|||:|||...|::.|||||||||.|:||..|..:..:|:|.|:||||.||||
 Worm   131 GIRENVSIAHSDLQMLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLEVIVIPHSHCDPGW 195

  Fly   160 IQTFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEF 224
            |.||||||...|::||....:||.:..||:||:||||:|..::.|..:..|.::|..::.|:.|.
 Worm   196 IMTFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQADEIKKKVKGYLEAGKFEI 260

  Fly   225 VTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFM--NVTPTASWAIDPFGHSPTMPYILQKSGFKN 287
            |||||||.||||:|:.:::.:|.||..|::..:  :..|.:.|:|||||.||:||::|..:...|
 Worm   261 VTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSHWSIDPFGLSPSMPHLLTSANITN 325

  Fly   288 MLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFK 352
            .:|||.|||||:|||.::.|||.|||::.:.|...|.:|:||||||||||||||:|.|||||||:
 Worm   326 AVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLRSHIMPFYSYDIPHTCGPEPSVCCQFDFR 390

  Fly   353 RMGSFGLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQ 417
            ||...|.||.|.:||:.|:|.|||.|::::.||::||::|::.||:..|||||||:..:.||:.|
 Worm   391 RMPEGGKSCDWGIPPQKINDDNVAHRAEMIYDQYRKKSQLFKNNVIFQPLGDDFRYDIDFEWNSQ 455

  Fly   418 RVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGY 482
            ..||::|||::||::.:||.||||||.:||..:..|..|...:.||.||||||||||.|:|||||
 Worm   456 YENYKKLFEYMNSKSEWNVHAQFGTLSDYFKKLDTAISASGEQLPTFSGDFFTYADRDDHYWSGY 520

  Fly   483 YTSRPYHKRMDRVLMHYVRAAEM--LSAWHSWDGM--ARIEERLEQARRELSLFQHHDGITGTAK 543
            :||||::|::||||.||:|:||:  ..|....:||  |:|.|:|..|||.|||||||||:|||||
 Worm   521 FTSRPFYKQLDRVLQHYLRSAEIAFTLANIEEEGMVEAKIFEKLVTARRALSLFQHHDGVTGTAK 585

  Fly   544 THVVVDYEQRMQEALKACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTII 608
            .|||:||.|:|.:||.||:.::.:::..||...|.       :...:|:.|
 Worm   586 DHVVLDYGQKMIDALNACEDILSEALVVLLGIDST-------NKMQMDEHR-------------- 629

  Fly   609 LGEDILPSK-------HVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPV-EAQVSPVWSWHHD 665
            :.|::||.|       :||:.|||...|.:.:...|.|....|.  |:.|: :.|||||.::..:
 Worm   630 VNENLLPEKRVYKIGQNVVLFNTLSRNRNEPICIQVDSLDAGVE--ADPPIKKQQVSPVIAYDEE 692

  Fly   666 TLTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPE 730
            ..|..:    ....:.:.|...:.||...::.|.      ::|:.:...::..|........:..
 Worm   693 KKTLVV----KNGIFELCFMLSLGPMESVSFRLV------KNTTTSKVEIITNNAAEFKETSFKS 747

  Fly   731 DVKFGDPREISLRVGNGPTLA--FSEQGLLK-SIQLTQDSPHVPVHFKFLKYGVR------SHGD 786
            ....||     ..|.|....|  ..|.|::| :..|..|.| :.::..|:.||.|      ::|:
 Worm   748 SSTSGD-----FTVKNDKVEAEFDGENGMIKRATSLVDDKP-IDLNSHFIHYGARKSKRKFANGN 806

  Fly   787 R---SGAYLFLPNGPASPVELGQPVVLVTKGKLESSVSVGLPS----VVHQTIMRGGAP--EIRN 842
            .   :|||||||:|.|..::......::.||::...| ...|:    ::....:..|.|  ::.|
 Worm   807 EDNPAGAYLFLPDGEARELKKQSSDWILVKGEVVQKV-FATPNNDLKILQTYTLYQGLPWIDLDN 870

  Fly   843 LVDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTR 907
            .||:.|.:|.|:.:|..:.::|||.|:|||||:|.|||||..|||.|||:||:.:|::|||..||
 Worm   871 EVDVRSKENFELALRFSSSVNSGDEFFTDLNGMQMIKRRRQTKLPTQANFYPMSAGVYIEDDTTR 935

  Fly   908 LTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSEL 972
            :::.:.|.||.|||:||::|||.||||:|||.|||.|||.|||..:..:|:|:|.:::.....:.
 Worm   936 MSIHSAQALGVSSLSSGQIEIMLDRRLSSDDNRGLQQGVRDNKRTVAHFRIVIEPMSSSSGNKKE 1000

  Fly   973 HPAGYLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDHPSARE----------DLDVSVMR 1027
            ...|:.:...|.|:.||..||.|.|             |...|.:..          ||.:...|
 Worm  1001 ERVGFHSHVGHLATWSLHYPLVKMI-------------GDATPKSISSKNVEQELNCDLHLVTFR 1052

  Fly  1028 RLT---------KSSAKTQRVGYVLHR-------------TNLMQCGTPEEHTQKLDVCHLLPNV 1070
            .|.         :|:|..::...|:||             |:.:..|.      :::...|:..:
 Worm  1053 TLASPTTYEANERSTAAEKKAAMVMHRVVPDCRSRLTLPDTSCLATGL------EIEPLKLISTL 1111

  Fly  1071 ARCERTTLTFL 1081
            ...::|:||.|
 Worm  1112 KSAKKTSLTNL 1122

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	175/340 (51%)
		Alpha-mann_mid	478..554	CDD:214875	49/79 (62%)
		Glyco_hydro_38C	744..1103	CDD:285047	122/388 (31%)
aman-2	NP_505995.2	PLN02701	142..1124	CDD:178304	402/1040 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159883
Domainoid	1	1.000	377	1.000	Domainoid score	I453
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55954
Inparanoid	1	1.050	704	1.000	Inparanoid score	I340
Isobase	1	0.950	-	0	Normalized mean entropy	S4542
OMA	1	1.010	-	-		QHG55783
OrthoDB	1	1.010	-	-		D1101882at2759
OrthoFinder	1	1.000	-	-		FOG0002281
OrthoInspector	1	1.000	-	-		oto20581
orthoMCL	1	0.900	-	-		OOG6_102728
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3970
SonicParanoid	1	1.000	-	-		X2015
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750