DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIa and aman-3

DIOPT Version :9

Sequence 1:	NP_001262413.1	Gene:	alpha-Man-IIa / 41126	FlyBaseID:	FBgn0011740	Length:	1109	Species:	Drosophila melanogaster
Sequence 2:	NP_001361919.1	Gene:	aman-3 / 172178	WormBaseID:	WBGene00018594	Length:	1046	Species:	Caenorhabditis elegans

Alignment Length:	984	Identity:	298/984 - (30%)
Similarity:	484/984 - (49%)	Gaps:	140/984 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LQEHGEEMR-----NLRARLAETSNRDDPIRPPLKVARSPRPGQCQDVVQDVPNVDVQMLELYDR 115
            |.:|..|:.     |:|:.:.|.:|..:..:.|  ....|:...||..:.: .:.:....:|::.
Worm    38 LGQHNNELHISRVVNMRSFVKEANNLSNSQKNP--NIFEPKNEVCQRPLTE-SSTNFNTFDLFES 99

  Fly   116 MSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALR 180
            :..|.          |......|.:...||||:|:|.:|.||||::|||.|.: .|..||.|..:
Worm   100 VVAKG----------NTLPPASKKSRTEKLKVYVLPFTHVDPGWLETFERYTK-STNQILDNMHQ 153

  Fly   181 HLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQ 245
            .:..|.:|:|:|||..:|.|::....|..|..:|.:|..|:||..||.|||.||||.::...:..
Worm   154 FMMKNEKMRFMWAEFVFFERWWSLQNEQVKEDVKKLVTEGRLELATGSWVMTDEANPYFPVSVDN 218

  Fly   246 LTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFL 310
            :.||..::.:...:.|...|:.||||:|.::||:.:|||....:|.|.|:.:|:.|..|:.:.|.
Worm   219 IVEGFQFIHKNFGIKPQTMWSNDPFGYSNSVPYLFKKSGVHRTVINRIHHKLKQTLQSQKAIPFK 283

  Fly   311 WRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNV 375
            |||.:|..|:..:.|.::|:..|||.::||.|..|||:||||||..:  |||...|.: |::.||
Worm   284 WRQYFDATGEDDVLTQILPYTHYDILNSCGSDASVCCEFDFKRMTHW--SCPGPKPEK-ITNANV 345

  Fly   376 AARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQF 440
            ||:::.||:|.:|.:|:|:..|:|:..||||||....||:.|..|:..:|:.||..:  .|:.:|
Worm   346 AAKAEKLVNQLEKMSEMYKAPVILMMHGDDFRFDMIEEWNQQHDNFIPVFDEINKGS--RVEIRF 408

  Fly   441 GTLQEYFDAVHQ-AERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAE 504
            ||..:||:.:.: ......:|.||:|||||.|.....:||:||||:||:.||..|:|...:|..:
Worm   409 GTFTDYFNDLEKWYSNNKDSEPPTVSGDFFPYMCALGDYWTGYYTTRPFFKRQGRLLHSLIRNGD 473

  Fly   505 -MLSAWHSWDGMARIE----------ERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEAL 558
             |||       |.|:.          :|||.|||.|:||||||.||||:|..|:.:|.:.:..::
Worm   474 IMLS-------MLRVNLKQRKIGENVKRLEAARRNLALFQHHDAITGTSKVSVMDNYSELLHASI 531

  Fly   559 KACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPS-KHVVMH 622
            .:..:|::.     |||..|   |.   |..:.|      |:|  ..||:   |:..| |.:.:.
Worm   532 VSTNIVLEN-----LTKSDI---DL---YPRIHD------GIE--LQTIV---DLESSEKEIRIF 574

  Fly   623 NTLPHWREQLVDFY---VSSPFVSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQGSTTK---YR 681
            |:  |..| :.|.:   |....| :..:....:|||:.|.:             |.|..:   :.
Worm   575 NS--HLFE-ITDVFKIRVKEREV-IVSIDGKIIEAQLEPFF-------------QKSKVEKDSFL 622

  Fly   682 IIFKARVPPMGLATYVLTISDS-----------KPEHTSYASNLLLRKNPTSLPLGQYPEDVKFG 735
            ::|:|.|.|:.:....:...||           |..:.....:.....:.||.|..:.|
Worm   623 LLFQATVLPLSMMKVKVQRGDSGGLTKMAKIEAKDTNAWDLGSSWTIASSTSAPNLETP------ 681

  Fly   736 DPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHGDRSGAYLFLPNGPAS 800
                 ..:|.|.|.     .|.::|:....|:........|  |..:..|  .||||...:  .:
Worm   682 -----YFKVSNDPI-----TGAIQSVNKLSDNSKFHCQQSF--YNYKEAG--GGAYLMRLH--TN 730

  Fly   801 PVELGQPVVLVTKGKLESSVSVGLPSVVHQTIMR------GGAPEIRNLVDIGSLDNTEIVMRLE 859
            |.|:.:...|...|.|..|:.....:|:.:..:.      |...:|...:||....|||::.|..
Worm   731 PKEIIEYQWLKVSGPLRQSIYQKSTNVLQRLSIHNVEGPSGEEVDISMSIDITKERNTELMTRFS 795

  Fly   860 THIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTRLTLLTGQPLGGSSLASG 924
            |..|. .:.|||..|:|.: ||...|||:|:||||:|:...::....||::::....|...|.||
Worm   796 TKWDK-PLTYTDSVGMQLL-RRDFYKLPVQSNYYPMPTAAVLQSGKQRLSIVSNVEHGARFLESG 858

  Fly   925 ELEIMQDRRLASDDERGLGQG----VLDNKPVLHIYRLVLEKVNNCVRPSELHPAGYLTSA--AH 983
            .:||..||.|..||.:|||.|    .:|.|||...::|:.:.:.:  .|:|  .:.|.|.:  |.
Worm   859 TVEINIDRILNQDDGKGLGTGPDAIPIDMKPVDMKFKLIFDSLES--DPTE--NSRYSTHSFRAQ 919

  Fly   984 KASQSLLDP 992
            :|.|:::.|
Worm   920 QAVQTIIYP 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	134/339 (40%)
		Alpha-mann_mid	478..554	CDD:214875	38/86 (44%)
		Glyco_hydro_38C	744..1103	CDD:285047	76/261 (29%)
aman-3	NP_001361919.1	PLN02701	117..978	CDD:178304	283/892 (32%)
aman-3	NP_001361919.1	GH38N_AMII_GMII_SfManIII_like	118..452	CDD:212120	134/339 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159884
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1101882at2759
OrthoFinder	1	1.000	-	-		FOG0002281
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.810