Protein Alignment alpha-Man-IIa and aman-3

DIOPT Version :10

• Sequence 1: NP_001262413.1
• Gene: alpha-Man-IIa / 41126
• FlyBaseID: FBgn0011740
• Length: 1109
• Species: Drosophila melanogaster
• Sequence 2: NP_001361919.1
• Gene: aman-3 / 172178
• WormBaseID: WBGene00018594
• Length: 1046
• Species: Caenorhabditis elegans
• Alignment Length: 984
• Identity: 298/984 - (30%)
• Similarity: 484/984 - (49%)
• Gaps: 140/984 - (14%)

  Fly    56 LQEHGEEMR-----NLRARLAETSNRDDPIRPPLKVARSPRPGQCQDVVQDVPNVDVQMLELYDR 115
            |.:|..|:.     |:|:.:.|.:|..:..:.|  ....|:...||..:.: .:.:....:|::.
 Worm    38 LGQHNNELHISRVVNMRSFVKEANNLSNSQKNP--NIFEPKNEVCQRPLTE-SSTNFNTFDLFES 99

  Fly   116 MSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALR 180
            :..|.          |......|.:...||||:|:|.:|.||||::|||.|.: .|..||.|..:
 Worm   100 VVAKG----------NTLPPASKKSRTEKLKVYVLPFTHVDPGWLETFERYTK-STNQILDNMHQ 153

  Fly   181 HLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQ 245
            .:..|.:|:|:|||..:|.|::....|..|..:|.:|..|:||..||.|||.||||.::...:..
 Worm   154 FMMKNEKMRFMWAEFVFFERWWSLQNEQVKEDVKKLVTEGRLELATGSWVMTDEANPYFPVSVDN 218

  Fly   246 LTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFL 310
            :.||..::.:...:.|...|:.||||:|.::||:.:|||....:|.|.|:.:|:.|..|:.:.|.
 Worm   219 IVEGFQFIHKNFGIKPQTMWSNDPFGYSNSVPYLFKKSGVHRTVINRIHHKLKQTLQSQKAIPFK 283

  Fly   311 WRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNV 375
            |||.:|..|:..:.|.::|:..|||.::||.|..|||:||||||..:  |||...|.: |::.||
 Worm   284 WRQYFDATGEDDVLTQILPYTHYDILNSCGSDASVCCEFDFKRMTHW--SCPGPKPEK-ITNANV 345

  Fly   376 AARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQF 440
            ||:::.||:|.:|.:|:|:..|:|:..||||||....||:.|..|:..:|:.||..:  .|:.:|
 Worm   346 AAKAEKLVNQLEKMSEMYKAPVILMMHGDDFRFDMIEEWNQQHDNFIPVFDEINKGS--RVEIRF 408

  Fly   441 GTLQEYFDAVHQ-AERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAE 504
            ||..:||:.:.: ......:|.||:|||||.|.....:||:||||:||:.||..|:|...:|..:
 Worm   409 GTFTDYFNDLEKWYSNNKDSEPPTVSGDFFPYMCALGDYWTGYYTTRPFFKRQGRLLHSLIRNGD 473

  Fly   505 -MLSAWHSWDGMARIE----------ERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEAL 558
             |||       |.|:.          :|||.|||.|:||||||.||||:|..|:.:|.:.:..::
 Worm   474 IMLS-------MLRVNLKQRKIGENVKRLEAARRNLALFQHHDAITGTSKVSVMDNYSELLHASI 531

  Fly   559 KACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPS-KHVVMH 622
            .:..:|::.     |||..|   |.   |..:.|      |:|  ..||:   |:..| |.:.:.
 Worm   532 VSTNIVLEN-----LTKSDI---DL---YPRIHD------GIE--LQTIV---DLESSEKEIRIF 574

  Fly   623 NTLPHWREQLVDFY---VSSPFVSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQGSTTK---YR 681
            |:  |..| :.|.:   |....| :..:....:|||:.|.:             |.|..:   :.
 Worm   575 NS--HLFE-ITDVFKIRVKEREV-IVSIDGKIIEAQLEPFF-------------QKSKVEKDSFL 622

  Fly   682 IIFKARVPPMGLATYVLTISDS-----------KPEHTSYASNLLLRKNPTSLPLGQYPEDVKFG 735
            ::|:|.|.|:.:....:...||           |..:.....:.....:.||.|..:.|
 Worm   623 LLFQATVLPLSMMKVKVQRGDSGGLTKMAKIEAKDTNAWDLGSSWTIASSTSAPNLETP------ 681

  Fly   736 DPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHGDRSGAYLFLPNGPAS 800
                 ..:|.|.|.     .|.::|:....|:........|  |..:..|  .||||...:  .:
 Worm   682 -----YFKVSNDPI-----TGAIQSVNKLSDNSKFHCQQSF--YNYKEAG--GGAYLMRLH--TN 730

  Fly   801 PVELGQPVVLVTKGKLESSVSVGLPSVVHQTIMR------GGAPEIRNLVDIGSLDNTEIVMRLE 859
            |.|:.:...|...|.|..|:.....:|:.:..:.      |...:|...:||....|||::.|..
 Worm   731 PKEIIEYQWLKVSGPLRQSIYQKSTNVLQRLSIHNVEGPSGEEVDISMSIDITKERNTELMTRFS 795

  Fly   860 THIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTRLTLLTGQPLGGSSLASG 924
            |..|. .:.|||..|:|.: ||...|||:|:||||:|:...::....||::::....|...|.||
 Worm   796 TKWDK-PLTYTDSVGMQLL-RRDFYKLPVQSNYYPMPTAAVLQSGKQRLSIVSNVEHGARFLESG 858

  Fly   925 ELEIMQDRRLASDDERGLGQG----VLDNKPVLHIYRLVLEKVNNCVRPSELHPAGYLTSA--AH 983
            .:||..||.|..||.:|||.|    .:|.|||...::|:.:.:.:  .|:|  .:.|.|.:  |.
 Worm   859 TVEINIDRILNQDDGKGLGTGPDAIPIDMKPVDMKFKLIFDSLES--DPTE--NSRYSTHSFRAQ 919

  Fly   984 KASQSLLDP 992
            :|.|:::.|
 Worm   920 QAVQTIIYP 928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	PLN02701	105..990	CDD:178304	286/926 (31%)
		Glyc_hyd_38C_2	1020..1108	CDD:408054
aman-3	NP_001361919.1	PLN02701	117..978	CDD:178304	283/892 (32%)
		GH38N_AMII_GMII_SfManIII_like	118..452	CDD:212120	134/339 (40%)