DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIa and Man2b2

DIOPT Version :9

Sequence 1:	NP_001262413.1	Gene:	alpha-Man-IIa / 41126	FlyBaseID:	FBgn0011740	Length:	1109	Species:	Drosophila melanogaster
Sequence 2:	NP_032576.2	Gene:	Man2b2 / 17160	MGIID:	1195262	Length:	1018	Species:	Mus musculus

Alignment Length:	911	Identity:	248/911 - (27%)
Similarity:	393/911 - (43%)	Gaps:	172/911 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 LKVFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHD--LGE 207
            ::.|||||||.|.||:.|.:|..:....::.:..:..|....:.:||..|..:| |.:.|  ..|
Mouse    27 IRAFVVPHSHMDVGWVFTVQESMRAYAANVYTTVVAELVRGGQRRFIAVEQEFF-RLWWDGVASE 90

  Fly   208 NKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGH 272
            .:|.|::.::..|:||||.||.||.|||.:|..:.:||||||..:|.:...:.|..||.:||||.
Mouse    91 QQKQQVRQLLHEGRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGIRPQFSWHVDPFGA 155

  Fly   273 SPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPH 337
            |.|.|.:...:||...||.|..|.:|..:.:.:.|:|:|.......|...:|||:|..|||
Mouse   156 SATTPTLFALAGFNAHLISRIDYDLKDAMQEAQMLQFVWHGSPSLSGQQEIFTHVMDHYSY---- 216

  Fly   338 TCGPDPKVCCQFDFKRMGSF---GLSCPWKVPP--------RTISDQNVAARSDLLVDQWKKKAE 391
             |.|.     ...|.....|   |::...:.||        ..::..|:...::.||...|::|.
Mouse   217 -CTPS-----HIPFSNRSGFYWNGVAVFPEPPPDGVYPNMSEPVTGANIHLYAEALVANVKQRAA 275

  Fly   392 LYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQ-AHFNVQAQFGTLQEYFDAVHQAE- 454
            .:||..:|.|.|.|   ||.....||..|.:.|.::||.: |.|.:..|:.||.:||.|:|...
Mouse   276 WFRTPHVLWPWGCD---KQFFNASVQFDNMDPLLDYINQRTAQFGISVQYATLNDYFQALHATNM 337

  Fly   455 ----RAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEMLSAWHSW-DG 514
                |..|        ||..|:......|:|:||||...|.:.|.....:.|.|.:...:.| |.
Mouse   338 TWGIRDHQ--------DFLPYSSEPLQAWTGFYTSRSTLKGLARQASALLYAGESMFTRYMWPDP 394

  Fly   515 MARIE-----ERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLT 574
            ...::     ::|:|.|..:|..||||.||||....|...|.:.::..:        ..|.:|:.
Mouse   395 SGTLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVKNMYTEHLRMGM--------LGVRKLMV 451

  Fly   575 KPSIYSPDFSFSYFTLDDSRWPGSG------VEDSRTTIILGEDILPSKH-VVMHNTLPHWR-EQ 631
            ..::..|              ||||      :...:.|.:|..|..|..: ..::|.|. |: ..
Mouse   452 SIALGGP--------------PGSGTGAPKDIMGPQVTPVLSVDTRPVGYSASVYNPLA-WKITT 501

  Fly   632 LVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQGST---TKYRIIFKARVPPMGL 693
            ::...|:.|.|||||...:||..|:                 |.||   :.|.::....:|.:..
Mouse   502 IITLTVAFPNVSVTDELGHPVSTQI-----------------QNSTKDPSAYDLLILTTIPGLNY 549

  Fly   694 ATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREISLRVGNGPT--------- 749
            ..|  .:..::.:.......:..|.|           .:||      ||::.|.|:
Mouse   550 RHY--QVMHARGDQAGTRELVAPRAN-----------TLKF------SLKLRNQPSQEGKRLVPV 595

  Fly   750 ------LAFSEQ-GLLKSIQLTQDSPHVPVHFKFLKYGVR---SHGDRSGAYLFLPNGPASP--V 802
                  |.|.:. .:|.|||..|.:..|.:..:||:|...   ..|..|..|||.||..|.|  .
Mouse   596 MNDCYILLFDQDTNMLHSIQDRQSNRTVRMTQEFLEYQANWDVKQGPISDNYLFAPNNTAEPSWE 660

  Fly   803 ELGQPVV--------------LVTKGKLESSVSVGL--PSVVHQTIMRGGAPEIRNLVDIGSLD- 850
            .:|..:|              .:|..:...|:...|  ||:..:.:.:    .|.....:|.||
Mouse   661 AVGMEMVAGTLVTDIRQYFYRYITDQEYIYSIHTRLAHPSLAGELLCQ----RIEQQYRVGPLDL 721

  Fly   851 NTEIVMRLETHIDSGDIFYTDLNGLQFIKR--RRLDKLPLQANYYPIPSGMFIEDANTRLTLLTG 913
            |.|.::|..:.::|..:.|:|.||.|..:|  :.....|:..||||:....||||..:||.||..
Mouse   722 NREAILRTSSDLNSQQVLYSDNNGYQMQRRPYKAFKSNPIPRNYYPMVQSAFIEDDKSRLVLLAE 786

  Fly   914 QPLGGSSLASGELEIMQDRR----LASDDERGLGQGVLDNKPVLH-IYRLVLEKVNNCVRPSELH 973
            :|.|.||..:|::|:|..||    ||.|.:..|   .|::..::| :..|:|...:..   :.||
Mouse   787 RPHGVSSQGNGQVEVMLHRRLWNNLAWDLKYNL---TLNDTSIVHPVLWLMLGPKSTM---TALH 845

  Fly   974 P 974
            |
Mouse   846 P 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	112/356 (31%)
		Alpha-mann_mid	478..554	CDD:214875	26/81 (32%)
		Glyco_hydro_38C	744..1103	CDD:285047	76/276 (28%)
Man2b2	NP_032576.2	GH38N_AMII_Epman_like	27..352	CDD:212122	110/346 (32%)
		Alpha-mann_mid	358..439	CDD:214875	26/80 (33%)
		Glyco_hydro_38C	491..1012	CDD:285047	101/403 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810