DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIa and Man2b1

DIOPT Version :9

Sequence 1:	NP_001262413.1	Gene:	alpha-Man-IIa / 41126	FlyBaseID:	FBgn0011740	Length:	1109	Species:	Drosophila melanogaster
Sequence 2:	XP_006530810.1	Gene:	Man2b1 / 17159	MGIID:	107286	Length:	1024	Species:	Mus musculus

Alignment Length:	1024	Identity:	267/1024 - (26%)
Similarity:	443/1024 - (43%)	Gaps:	237/1024 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 LKVFVVPHSHNDPGWIQTFEEYY------------------QH-DTKHILSNALRHLHDNPEMKF 190
            |.|.::||:|:|.||::|.::||                  || ..::||.:.:..|.:.|..:|
Mouse    63 LNVHLLPHTHDDVGWLKTVDQYYYGMDLDFLNFMPTVLSDVQHASVQYILDSVVSSLLEKPTRRF 127

  Fly   191 IWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQ 255
            |:.|:::|:|::.......:..::::|:.|:||||.|||||.|||.:|:..::.|:|.|..:|:.
Mouse   128 IYVEMAFFSRWWKQQTSATQDAVRNLVRQGRLEFVNGGWVMNDEAATHYGAIVDQMTLGLRFLQD 192

  Fly   256 FM--NVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNK 318
            ..  :..|..:|.|||||||.....:..:.||....:.|..|..|....::.::|.|||.....:
Mouse   193 TFGSDGLPRVAWHIDPFGHSREQASLFAQMGFDGFFLGRIDYQDKLNRKKKLRMEELWRASDSLE 257

  Fly   319 GDTA-LFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKV----PPRTISDQNVAAR 378
            ...| |||.::| .:|:       .||..|               |.|    ||...:.::....
Mouse   258 PPAADLFTGVLP-NNYN-------PPKYLC---------------WDVLCTDPPVVDNPRSPEFN 299

  Fly   379 SDLLVDQWKKKAE----LYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFN---V 436
            :..||:.:.|.|.    .||||..::.:|.||.::....|   ..|.::|...:|:| ..|   |
Mouse   300 AKTLVNYFLKLASSQKGFYRTNHTVMTMGSDFHYENANMW---FKNMDKLIRLVNAQ-QVNGSLV 360

  Fly   437 QAQFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVR 501
            ...:.|...|...:::|    ...:.....|||.|||....:|:||::|||..||.:|:..::::
Mouse   361 HVLYSTPTCYLWELNKA----NLTWTVKEDDFFPYADGPHMFWTGYFSSRPALKRYERLSYNFLQ 421

  Fly   502 AAEMLSA----------WHSWDGMARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQE 556
            ....|.|          :.|.|. |.::|       .:::.||||.::|||:.:||.||.:::..
Mouse   422 VCNQLEALVGPEANVGPYGSGDS-APLQE-------AMAVLQHHDAVSGTARQNVVNDYARQLAA 478

  Fly   557 ALKACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSKHVVM 621
            ....|::::..::.||    |.|..:|||.. .|:.|..|.|...:             ...|.:
Mouse   479 GWGPCEVLVSNALARL----SHYKQNFSFCR-ELNISICPVSQTSE-------------RFQVTL 525

  Fly   622 HNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKA 686
            :|.|....:|:|...|......|.|..:..:.:.|..|.|::.:|.           ::.::|.|
Mouse   526 YNPLGRKVDQMVRLPVYEGNFIVKDPHDKNISSNVVMVPSYYSETY-----------QWELLFPA 579

  Fly   687 RVPPMGLATY-VLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREISLRVGNGPTL 750
            .||.:|.:|| |..:||...:    |.|||.|      |.......|...:.:.:.....:|
Mouse   580 SVPALGFSTYSVAKMSDLNHQ----AHNLLSR------PRKHKSHHVLVIENKYMRATFDSG--- 631

  Fly   751 AFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHGDR-----SGAYLFLPNGPASPVELGQPVVL 810
                .|||..|:..:.:..:||...|..|.. |.||.     ||||:|.||       :|:|:.
Mouse   632 ----TGLLMKIENLEQNLSLPVSQGFFWYNA-SVGDEESSQASGAYIFRPN-------VGKPIP- 683

  Fly   811 VTKGKLESSVSVGLPSVVHQT----------IMRG----------GAPEIRNLVDIGSLDNTEIV 855
            |::....|.|...|...|||.          :.:|          |...:|:  |.|.    |::
Mouse   684 VSRWAQISLVKTALVQEVHQNFSAWCSQVIRLYKGQRHLELEWTVGPIPVRD--DWGK----EVI 742

  Fly   856 MRLETHIDSGDIFYTDLNGLQFIKRR-------RLDKL-PLQANYYPIPSGMFIEDANTRLTLLT 912
            .|.:|.:.:...|:||.||.:.:|||       .|::. |:..||||:.:.::|.|...:||:||
Mouse   743 SRFDTPMKTKGQFFTDSNGREILKRRDDYRPTWTLNQTEPVAGNYYPVNTRIYITDGQMQLTVLT 807

  Fly   913 GQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLD---NKPVLHIYRLVLEKVNNCVRPSELHP 974
            .:..|||||..|.||:|..|||..||:||:.:.:|:   ...|...:.::|..|::
Mouse   808 DRSQGGSSLQDGSLELMVHRRLLVDDDRGVSEPLLETDTGDKVRGRHLVLLSSVSD--------- 863

  Fly   975 AGYLTSAAHKASQSLLDPLDKFIFAENEWIGAQG--QFGGDHPSAREDLDVSVMRRLTKSSAKTQ 1037
                .:|.|:            :.||.|.:..|.  ..||..|..            ::::.|||
Mouse   864 ----AAARHR------------LLAEQEVLAPQVVLSLGGSSPYH------------SRATPKTQ 900

  Fly  1038 RVGYVLHRTNLMQCGTPEEHTQKLDVCHLLPNVARCERTTLTFLQNLEH 1086
            ..|       |.|...|:.|         |..:||.....|  |..|||
Mouse   901 FSG-------LRQELPPQVH---------LLTLARWGPKML--LLRLEH 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	101/370 (27%)
		Alpha-mann_mid	478..554	CDD:214875	26/85 (31%)
		Glyco_hydro_38C	744..1103	CDD:285047	101/381 (27%)
Man2b1	XP_006530810.1	PLN02701	63..917	CDD:178304	260/1006 (26%)
Man2b1	XP_006530810.1	GH38N_AMII_LAM_like	63..352	CDD:212121	86/314 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3970
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840