Protein Alignment alpha-Man-IIa and Man2a1

DIOPT Version :10

• Sequence 1: NP_001262413.1
• Gene: alpha-Man-IIa / 41126
• FlyBaseID: FBgn0011740
• Length: 1109
• Species: Drosophila melanogaster
• Sequence 2: NP_032575.2
• Gene: Man2a1 / 17158
• MGIID: 104669
• Length: 1150
• Species: Mus musculus
• Alignment Length: 1194
• Identity: 465/1194 - (38%)
• Similarity: 675/1194 - (56%)
• Gaps: 143/1194 - (11%)

  Fly     2 LRIRRRFAL----VICSGCLLVFLSLYIIL---NFAAPAATQ----IKQPNYENIENKLHELENG 55
            :::.|:|.:    :.|    :|..|||::|   :...|...:    ..|.....::.|:..||..
Mouse     1 MKLSRQFTVFGSAIFC----VVIFSLYLMLDRGHLDYPRGPRQEGSFPQGQLSILQEKIDHLERL 61

  Fly    56 LQEHGEEMRNLRARLAETSN--RDDPIRPPLKVAR------SPR------PGQCQDVVQ--DVPN 104
            |.|:.|.:.|:|..:...|.  .|.|...|...::      ||:      |..|....|  ..|.
Mouse    62 LAENNEIISNIRDSVINLSESVEDGPRGSPGNASQGSIHLHSPQLALQADPRDCLFASQSGSQPR 126

  Fly   105 VDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQH 169
             |||||::||.:.|.:.||||||||::|||:..::: |..|:|||||||||||||::||.:|::.
Mouse   127 -DVQMLDVYDLIPFDNPDGGVWKQGFDIKYEADEWD-HEPLQVFVVPHSHNDPGWLKTFNDYFRD 189

  Fly   170 DTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDE 234
            .|::|.:|.:..|.::...||:|:||||.|:::..:...||..:||:::|||||.||||||||||
Mouse   190 KTQYIFNNMVLKLKEDSSRKFMWSEISYLAKWWDIIDIPKKEAVKSLLQNGQLEIVTGGWVMPDE 254

  Fly   235 ANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKK 299
            |..|:..::.||.||..||::.:.|.|.:.||||||||||||.|:|:::||.:|||||.||::||
Mouse   255 ATPHYFALIDQLIEGHQWLEKNLGVKPRSGWAIDPFGHSPTMAYLLKRAGFSHMLIQRVHYAIKK 319

  Fly   300 ELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRM--GSFGLSCP 362
            ..:..:.|||.|||.||....|.:..|||||||||||||||||||:||||||||:  |.:|  ||
Mouse   320 HFSLHKTLEFFWRQNWDLGSATDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRYG--CP 382

  Fly   363 WKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEH 427
            |.|||..||..||.:|:.:|:||::||::|:||.|||.||||||||.:.||||:|..|||:||.:
Mouse   383 WGVPPEAISPGNVQSRAQMLLDQYRKKSKLFRTKVLLAPLGDDFRFSEYTEWDLQCRNYEQLFSY 447

  Fly   428 INSQAHFNVQAQFGTLQEYFDAVHQA----ERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPY 488
            :|||.|..|:.|||||.:||||:.:|    :::.|:.||.|||||||||||.|:|||||:||||:
Mouse   448 MNSQPHLKVKIQFGTLSDYFDALEKAVAAEKKSSQSVFPALSGDFFTYADRDDHYWSGYFTSRPF 512

  Fly   489 HKRMDRVLMHYVRAAEM-----------------LSAWHSWDGMARIEERLEQARRELSLFQHHD 536
            :|||||::...:||||:                 ||:.|        ...|.:|||.|.||||||
Mouse   513 YKRMDRIMESRIRAAEILYQLALKQAQKYKINKFLSSPH--------YTTLTEARRNLGLFQHHD 569

  Fly   537 GITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTK-PSIYSPDFSFSYFTLDDSRWPGSGV 600
            .||||||..|||||..|:.::|.:.:.::..|.:.|:.| ..:|..|.|.::..:|..:   |..
Mouse   570 AITGTAKDWVVVDYGTRLFQSLNSLEKIIGDSAFLLILKDKKLYQSDPSKAFLEMDTKQ---SSQ 631

  Fly   601 EDSRTTIILGEDILPSKHVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHD 665
            :.....||:.......:::|::|.....|..:|...|:|..|.|...:..|||.|||.||   :|
Mouse   632 DSLPQKIIIQLSAQEPRYLVVYNPFEQERHSVVSIRVNSATVKVLSDSGKPVEVQVSAVW---ND 693

  Fly   666 TLTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQY-- 728
              .:||    |...|.:.|.|.:||:||..:.:..|.|.   :|:.::.:|..|......|.:
Mouse   694 --MRTI----SQAAYEVSFLAHIPPLGLKVFKILESQSS---SSHLADYVLYNNDGLAENGIFHV 749

  Fly   729 PEDVKFGDPREISLRVGNGPTLA--FSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHGDRSGAY 791
            ...|..||    ::.:.| |.||  |...||::.::..:||....:..:||.||..:..|:||||
Mouse   750 KNMVDAGD----AITIEN-PFLAIWFDRSGLMEKVRRKEDSRQHELKVQFLWYGTTNKRDKSGAY 809

  Fly   792 LFLPNGPASP-VELGQPVVLVTKGKLESSVSVGLPSVVHQTIM------RGGAPEIRNLVDIGSL 849
            ||||:|...| |.|..|.|.||:|::.|.|:..|..|.|:..:      .|.:.|:.|:|:|.::
Mouse   810 LFLPDGQGQPYVSLRPPFVRVTRGRIYSDVTCFLEHVTHKVRLYNIQGIEGQSMEVSNIVNIRNV 874

  Fly   850 DNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTRLTLLTGQ 914
            .|.|||||:.:.|::.:.:||||||.|...||.:.|||||||.||:.:..:|:||..|||||:.|
Mouse   875 HNREIVMRISSKINNQNRYYTDLNGYQIQPRRTMSKLPLQANVYPMCTMAYIQDAEHRLTLLSAQ 939

  Fly   915 PLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEK---VNNCVRPSELHPAG 976
            .||.||:|||::|:..||||..||.|||||||.|||...:::|::|||   ||  :...:..|..
Mouse   940 SLGASSMASGQIEVFMDRRLMQDDNRGLGQGVHDNKITANLFRILLEKRSAVN--MEEEKKSPVS 1002

  Fly   977 YLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDHPSAREDL-------------DVSV--M 1026
            |.:..:|..|..|..|....:.:            |..||...:|             |:.:  :
Mouse  1003 YPSLLSHMTSSFLNHPFLPMVLS------------GQLPSPAFELLSEFPLLQSSLPCDIHLVNL 1055

  Fly  1027 RRLTKSSAK--TQRVGYVLHRTNLMQC-------GTPEEHTQ-KLDVCHLLPN--VARCERTTLT 1079
            |.:.....|  :.....:|||.. ..|       |.|...|| |:.|..|...  |.....::|:
Mouse  1056 RTIQSKMGKGYSDEAALILHRKG-FDCQFSSRGIGLPCSTTQGKMSVLKLFNKFAVESLVPSSLS 1119

  Fly  1080 FLQNLEHLDGMVAPEVCPMETAAY 1103
            .:.:......|....:.|||.:.:
Mouse  1120 LMHSPPDAQNMSEVSLSPMEISTF 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	PLN02701	105..990	CDD:178304	411/922 (45%)
		Glyc_hyd_38C_2	1020..1108	CDD:408054	21/111 (19%)
Man2a1	NP_032575.2	PLN02701	127..1148	CDD:178304	437/1063 (41%)