DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIa and man2a1

DIOPT Version :9

Sequence 1:	NP_001262413.1	Gene:	alpha-Man-IIa / 41126	FlyBaseID:	FBgn0011740	Length:	1109	Species:	Drosophila melanogaster
Sequence 2:	NP_001163963.1	Gene:	man2a1 / 100036612	XenbaseID:	XB-GENE-961025	Length:	1150	Species:	Xenopus tropicalis

Alignment Length:	1166	Identity:	452/1166 - (38%)
Similarity:	643/1166 - (55%)	Gaps:	183/1166 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 CLLVFLSLYIILN---FAAPAATQIKQPNYEN---------IENKLHELENGLQEHGEEMRNLR- 67
            |:::| |||::|:   |..|     |.|..|.         :::|:..||..|.|:.|.:.|:|
Frog    16 CVVIF-SLYLMLDRGQFDQP-----KSPRREGALPKGQLSILQDKIDHLERLLAENNEIISNIRD 74

  Fly    68 --ARLAE-----------------TSNRDDPIRPPLKVARSPRPGQCQDV-VQDVPNVDVQMLEL 112
              ..|:|                 :|::.:|..|......:.   .||.. |......:||||::
Frog    75 SVINLSESVKDGQKNSDSQNFSRGSSSQLEPSAPAFLPINNE---DCQFASVTGGHKSNVQMLDV 136

  Fly   113 YDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKHILSN 177
            ||.:.|.:.||||||||::|.||..::: :..|:||:||||||||||::||::|::..|:|||:|
Frog   137 YDILPFDNPDGGVWKQGFDISYDEHEWD-NEPLQVFLVPHSHNDPGWLKTFDDYFRDQTQHILNN 200

  Fly   178 ALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNV 242
            .:..|.::...||:|:|||||::::..:...||..:|.:::..|.|.|||||||||||..|:.::
Frog   201 MVIKLQEDKNRKFMWSEISYFSKWWDGIDNQKKEAVKRLIELEQFEIVTGGWVMPDEATPHYFSL 265

  Fly   243 LLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQL 307
            :.||.||..||::.:.|.|.:.||||||||||||.|||:.||..||||||.|||:||..|.::.|
Frog   266 VDQLIEGHQWLEKNLGVKPKSGWAIDPFGHSPTMAYILKSSGLSNMLIQRVHYSIKKYFASKQTL 330

  Fly   308 EFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISD 372
            ||.|||.||....|.:..|||||||||:|||||||||:||||||||:....:||||:|||..|::
Frog   331 EFFWRQNWDLGHSTDILCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGSRVSCPWRVPPEVINE 395

  Fly   373 QNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQ 437
            .||..|:.:::||::||::||||.|||:|||||||:..:.|||.|..||::||.::||....:|:
Frog   396 GNVQHRAWMILDQYRKKSKLYRTKVLLVPLGDDFRYTDSLEWDQQYENYQKLFSYMNSHPELHVK 460

  Fly   438 AQFGTLQEYFDAVHQA---ERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHY 499
            |||||:.:||.|:.:|   :......||.|||||||||||.|:|||||:||||::||::||:..:
Frog   461 AQFGTISDYFKALRKAGNVDDPNSQSFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRLERVMESH 525

  Fly   500 VRAAEMLSAW-----HSWDGMARIE-----ERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRM 554
            :||||:|.::     :.:|.:....     :.|.:|||.|.||||||.||||||..|||||..|:
Frog   526 LRAAEILYSFALVQMNKFDKLQSFPSVEHYKLLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRL 590

  Fly   555 QEALKACQMVMQQSVYRLLTKPS---IYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPS 616
            ..:|...:.|:..:.:.|:.|..   .|:|  |..:|::||       |:.|       :|.||.
Frog   591 FHSLMNLKRVIIDAAHVLVLKDKDTYAYNP--SSPFFSMDD-------VQPS-------QDSLPQ 639

  Fly   617 KHVVMHNTLPHW----------REQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHDTLTKTI 671
            |.|:....:|.:          |..:|..||||..|.|...:...::||:|.||:.....|
Frog   640 KTVIKITEIPRYLTVYNPTEQERYSVVSVYVSSSKVKVISASGKALKAQISAVWNGDSAPL---- 700

  Fly   672 HPQGSTTKYRIIFKARVPPMGLATYVLTISDS----KPEHTSYASNLLLRKNPTSLPLGQYPEDV 732
                 ...|::.|.|.:|.:|||.|.|..:::    |.::|.:...  ..||..|        |.
Frog   701 -----QDMYQVSFLAYLPALGLAVYKLVEAENSESIKADYTIFVQG--KHKNINS--------DG 750

  Fly   733 KFGDPREISLRVGNGP------TLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHGDRSGAY 791
            .| ..:|:::.||:..      .|.||..|||:.||..:|.....|...|:.||..::.|:||||
Frog   751 NF-RIKEVNIVVGDVTIENTYLKLWFSSSGLLEKIQSKEDGKTHGVKVDFIWYGTTNNRDKSGAY 814

  Fly   792 LFLPNGPASP-VELGQPVVLVTKGKLESSVSVGLPSVVHQTI-------MRGGAPEIRNLVDIGS 848
            ||||:|.|.| :....|||.||.|.:.|.|.|....:.| |:       :.|.:|||.|:|||..
Frog   815 LFLPDGEAKPYINADPPVVRVTHGSIFSEVVVFFKHLTH-TVRLYNVHGLEGQSPEITNVVDIRG 878

  Fly   849 LDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTRLTLLTG 913
            ..|.|||||:.:.|:|...|||||||.|...||.|.|||:|||.||:.|..:|:|..:||||.:.
Frog   879 EFNREIVMRITSDINSKHRFYTDLNGYQIQPRRTLSKLPIQANVYPMTSMAYIQDDASRLTLHSA 943

  Fly   914 QPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSELHPAGYL 978
            |.||.:|..||:||:..||||..||.|||||||.|||...:::||:|||........:..|..|.
Frog   944 QSLGVASSKSGQLEVFLDRRLMQDDNRGLGQGVQDNKITSNLFRLLLEKRFGKDEKEDEKPVSYP 1008

  Fly   979 TSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDHPSAREDLDVSVMRRLTKSSAKTQRVGYVL 1043
            :..:|..|..|                       :||        .:....|..|..:..:...|
Frog  1009 SILSHITSMFL-----------------------NHP--------VIPMAATSDSGSSVLLNAFL 1042

  Fly  1044 HRTNLMQCGTPEEHTQKLDVCHLLPNVARCERTTLTFLQNLEHLDGMVAPEVCPMETAAYV 1104
            ..|:.|.|          || |||               ||..:...|.|  .|.:.||.:
Frog  1043 PLTSSMPC----------DV-HLL---------------NLRTIQAKVGP--IPSDEAALI 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	186/341 (55%)
		Alpha-mann_mid	478..554	CDD:214875	41/85 (48%)
		Glyco_hydro_38C	744..1103	CDD:285047	133/372 (36%)
man2a1	NP_001163963.1	PLN02701	130..1150	CDD:178304	425/1043 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	431	1.000	Domainoid score	I582
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	765	1.000	Inparanoid score	I541
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1101882at2759
OrthoFinder	1	1.000	-	-		FOG0002281
OrthoInspector	1	1.000	-	-		otm49416
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2015
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060