Protein Alignment Task7 and KCNK13

DIOPT Version :10

• Sequence 1: NP_649891.1
• Gene: Task7 / 41125
• FlyBaseID: FBgn0037690
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_071337.2
• Gene: KCNK13 / 56659
• HGNCID: 6275
• Length: 408
• Species: Homo sapiens
• Alignment Length: 279
• Identity: 91/279 - (32%)
• Similarity: 131/279 - (46%)
• Gaps: 49/279 - (17%)

  Fly     2 MKRQNVRTLSLVVCTFTYLLIGAAVFDSLESPTE---AKRWEFLQTVKNNFVRKYNVTDEDFR-- 61
            :...|.|.|.|......|||.|||||.:||...|   .:|||....   ||.|.:|::.::.|
Human    13 LNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLA---NFSRGHNLSRDELRGF 74

  Fly    62 -------VMEIVIIENKPHKAGPQWKFAGAFYFSTVVLAMIGYGHSTPVTIPGKAFCMGYAMVGI 119
                   ....:.::|    ..|:|.|.|||||...|::.||:|.:||.|:.||.|.:.|.:||.
Human    75 LRHYEEATRAGIRVDN----VRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGC 135

  Fly   120 PLGLVMFQSIGERLNKFASVIIR----RAKRASGA----RCTDATEMN-------------LMLA 163
            ...::.|....|||....:.|::    |..|..||    ...||.:..             :||.
Human   136 SSTILFFNLFLERLITIIAYIMKSCHQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLI 200

  Fly   164 TGMLSSIIITTGAAVFSRYEGWSYFDSFYYCFVTLTTIGFGDYVALQN----DQALTNKPGYVAL 224
            ....|.:|....:|:::..||||||||.|:|||..:||||||.|:.||    .|.|     |...
Human   201 LCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGFGDLVSSQNAHYESQGL-----YRFA 260

  Fly   225 SLVFILFGLAVVAASINLL 243
            :.||||.|:..:.:..|::
Human   261 NFVFILMGVCCIYSLFNVI 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Task7	NP_649891.1	Ion_trans_2	<74..133	CDD:462301	23/58 (40%)
		Ion_trans_2	166..244	CDD:462301	33/82 (40%)
KCNK13	NP_071337.2	Ion_trans_2	<93..150	CDD:462301	24/56 (43%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	110..115		2/4 (50%)
		Ion_trans_2	206..285	CDD:462301	32/79 (41%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	237..242		4/4 (100%)