Protein Alignment Task7 and Kcnk6

DIOPT Version :10

• Sequence 1: NP_649891.1
• Gene: Task7 / 41125
• FlyBaseID: FBgn0037690
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_001028697.2
• Gene: Kcnk6 / 52150
• MGIID: 1891291
• Length: 313
• Species: Mus musculus
• Alignment Length: 257
• Identity: 71/257 - (27%)
• Similarity: 124/257 - (48%)
• Gaps: 48/257 - (18%)

  Fly    19 YLLIGAAVFDSLESPTEAKRWEFLQTVKNNFVR-----KYNVTDEDFRVMEIVIIENKPHKAG-- 76
            ||.:||.:...||.|.||:....|.|::...::     ..:..|   ..:|.|:...:..:|.
Mouse    17 YLALGALLVARLERPHEARLRAELGTLREQLLQHSPCVAAHALD---AFVERVLAAGRLGRAALA 78

  Fly    77 ----------PQWKFAGAFYFSTVVLAMIGYGHSTPVTIPGKAFCMGYAMVGIPLGLVMFQSIGE 131
                      |.|.||.|.:|::.::..:|||::||:|..||||.:.:|::|:|:.:::..:..:
Mouse    79 NASGAANASDPAWDFASALFFASTLVTTVGYGYTTPLTDAGKAFSIVFALLGVPITMLLLTASAQ 143

  Fly   132 RLNKFASVIIRRAKRA-----SGARCTDATEMNLMLATGMLSSIIITTGAAVFSRY-EGWSYFDS 190
            ||    |:::..|..:     .|.....|...:|:....::.:|.....||||:.. |.||:.|:
Mouse   144 RL----SLLLTHAPLSWLSLHWGWPPQRAARWHLVALLMVIVAIFFLVPAAVFAYLEEAWSFLDA 204

  Fly   191 FYYCFVTLTTIGFGDYVALQNDQALTNKPG------YVALSLVFILFGLAVVAASINLLVLR 246
            ||:||::|:|||.||||.       ...||      |..|...::..||..:     :|||:
Mouse   205 FYFCFISLSTIGLGDYVP-------GEAPGQPYRALYKVLVTAYLFLGLVAM-----VLVLQ 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Task7	NP_649891.1	Ion_trans_2	<74..133	CDD:462301	20/70 (29%)
		Ion_trans_2	166..244	CDD:462301	27/84 (32%)
Kcnk6	NP_001028697.2	Ion_trans_2	<89..146	CDD:462301	21/60 (35%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	106..111		2/4 (50%)
		Ion_trans_2	180..259	CDD:462301	30/87 (34%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	214..219		3/4 (75%)
		Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8	282..290
		Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8	308..312