Protein Alignment Task7 and KCNK4

DIOPT Version :10

• Sequence 1: NP_649891.1
• Gene: Task7 / 41125
• FlyBaseID: FBgn0037690
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_201567.1
• Gene: KCNK4 / 50801
• HGNCID: 6279
• Length: 393
• Species: Homo sapiens
• Alignment Length: 257
• Identity: 79/257 - (30%)
• Similarity: 120/257 - (46%)
• Gaps: 33/257 - (12%)

  Fly    10 LSLVVCTFTYLLIGAAVFDSLESPTEAKRWEFLQTVKNNFVRKYN-VTDEDFRVM---------- 63
            |:|:.....||:.||.||.:||.|.|.:....|..|:..|:|.:. |:|::..::
Human     7 LALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGLLIKEVADALGG 71

  Fly    64 ----EIVIIENKPHKAGPQWKFAGAFYFSTVVLAMIGYGHSTPVTIPGKAFCMGYAMVGIPLGLV 124
                |.....|..|.|   |....||:||..::..||||:....|..|:.||:.||:|||||..:
Human    72 GADPETNSTSNSSHSA---WDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGI 133

  Fly   125 MFQSIGERLNK--------FASVIIRRAKRASGARCTDATEMNLMLATGMLSSIIITTGAAVFSR 181
            :...:|:||..        ..::.::........|...|.   |.|..|.|  :.:.|...||..
Human   134 LLAGVGDRLGSSLRHGIGHIEAIFLKWHVPPELVRVLSAM---LFLLIGCL--LFVLTPTFVFCY 193

  Fly   182 YEGWSYFDSFYYCFVTLTTIGFGDYVALQNDQALTNKPGYVALSLVFILFGLAVVAASINLL 243
            .|.||..::.|:..|||||:|||||||..:.:  .:.|.|..|...:||.|||..|:.:..:
Human   194 MEDWSKLEAIYFVIVTLTTVGFGDYVAGADPR--QDSPAYQPLVWFWILLGLAYFASVLTTI 253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Task7	NP_649891.1	Ion_trans_2	<74..133	CDD:462301	22/58 (38%)
		Ion_trans_2	166..244	CDD:462301	29/78 (37%)
KCNK4	NP_201567.1	Ion_trans_2	<88..142	CDD:462301	21/53 (40%)
		Selectivity filter 1. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	103..108		3/4 (75%)
		Ion_trans_2	180..258	CDD:462301	29/78 (37%)
		Selectivity filter 2. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	212..217		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..393