Protein Alignment Task7 and KCNS2

DIOPT Version :10

• Sequence 1: NP_649891.1
• Gene: Task7 / 41125
• FlyBaseID: FBgn0037690
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_065748.1
• Gene: KCNS2 / 3788
• HGNCID: 6301
• Length: 477
• Species: Homo sapiens
• Alignment Length: 281
• Identity: 60/281 - (21%)
• Similarity: 98/281 - (34%)
• Gaps: 119/281 - (42%)

  Fly    28 DSLESPTEAKRWEFLQ---------------TVKNNFVRKY----NVTDEDFRVMEIVIIENKPH 73
            ||..:|.|..|:|.::               .|..:|::.:    |:.|    :|.||
Human   216 DSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLID----LMSIV------- 269

  Fly    74 KAGPQWKFAGAFYFSTVVLAMIGYGHSTPVTIPGKAFCMGYAMVGIPLGLVMFQSIGERLNKFAS 138
                      .||.:.||..::   .|||..                          ..|.:.|.
Human   270 ----------PFYITLVVNLVV---ESTPTL--------------------------ANLGRVAQ 295

  Fly   139 V--------IIRRAKRASGARCTDAT------EMNLMLATGMLSSIIITTGAAVFS--------- 180
            |        |::.|:.::|.|...||      |:.|:|       :.::.|.::||
Human   296 VLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLL-------LYLSVGISIFSVVAYTIEKE 353

  Fly   181 RYEGWSYFDS-FYYCFVTLTTIGFGDYVALQNDQALTNKPGYVALSL---VFILFGLAVVAASIN 241
            ..||.:...: :::..|::||:|:||.|           ||..|..|   ..||.|:.||...|.
Human   354 ENEGLATIPACWWWATVSMTTVGYGDVV-----------PGTTAGKLTASACILAGILVVVLPIT 407

  Fly   242 LLVLRF-----MTMQAEDAKR 257
            |:..:|     ...|.|.|.|
Human   408 LIFNKFSHFYRRQKQLESAMR 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Task7	NP_649891.1	Ion_trans_2	<74..133	CDD:462301	7/58 (12%)
		Ion_trans_2	166..244	CDD:462301	23/90 (26%)
KCNS2	NP_065748.1	BTB_POZ_KCNS2	18..124	CDD:349734
		Ion_trans	186..421	CDD:459842	56/272 (21%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		2/4 (50%)