Protein Alignment Task7 and KCNK2

DIOPT Version :10

• Sequence 1: NP_649891.1
• Gene: Task7 / 41125
• FlyBaseID: FBgn0037690
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_001017425.2
• Gene: KCNK2 / 3776
• HGNCID: 6277
• Length: 426
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 92/323 - (28%)
• Similarity: 145/323 - (44%)
• Gaps: 60/323 - (18%)

  Fly     1 MMKRQNVRTLSLVVCTFTYLLIGAAVFDSLESPTEAKRWEFLQTVKNNFVRKY---NVTDEDFRV 62
            :||.:.|.|:.|||  ..||:|||.||.:||.|.|..:...:...|..|:.::   |.|:.|..:
Human    56 VMKWKTVSTIFLVV--VLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELI 118

  Fly    63 MEIVIIENKPHKAG-----------PQWKFAGAFYFSTVVLAMIGYGHSTPVTIPGKAFCMGYAM 116
            .:||...|    ||           ..|....:|:|:..|:..||:|:.:|.|..||.||:.||:
Human   119 QQIVAAIN----AGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYAL 179

  Fly   117 VGIPLGLVMFQSIGERLNKFASVIIRRAKRASGARCTDATEMNLMLATGMLSSII---------I 172
            :||||...:...:|::|.......|.:.:..........|::.:      :|:||         :
Human   180 LGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRI------ISTIIFILFGCVLFV 238

  Fly   173 TTGAAVFSRYEGWSYFDSFYYCFVTLTTIGFGDYVALQNDQALTNKPGYVALSLVFILFGLAVVA 237
            ...|.:|...||||..|:.|:..:||||||||||||..:|  :.....|..:...:||.|||..|
Human   239 ALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSD--IEYLDFYKPVVWFWILVGLAYFA 301

  Fly   238 ASINLL--VLRFMTMQAEDAKRDEQDAQNLAGNAQPVTFDDESTYNMHGKLLENNYTTENDET 298
            |.::::  .||.::.:                     |.::...:..|......|.|.|..||
Human   302 AVLSMIGDWLRVISKK---------------------TKEEVGEFRAHAAEWTANVTAEFKET 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Task7	NP_649891.1	Ion_trans_2	<74..133	CDD:462301	22/69 (32%)
		Ion_trans_2	166..244	CDD:462301	32/88 (36%)
KCNK2	NP_001017425.2	Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000250|UniProtKB:Q920B6	17..38
		Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000250|UniProtKB:Q920B6	51..61		2/4 (50%)
		Ion_trans_2	<138..196	CDD:462301	20/57 (35%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:Q920B6	157..162		2/4 (50%)
		Ion_trans_2	234..312	CDD:462301	29/79 (37%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:Q920B6	266..271		4/4 (100%)
		Interaction with AKAP5. /evidence=ECO:0000250|UniProtKB:P97438	313..326		1/33 (3%)
		Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250|UniProtKB:P97438	337..385		4/7 (57%)