Protein Alignment Task7 and KCNK1

DIOPT Version :10

• Sequence 1: NP_649891.1
• Gene: Task7 / 41125
• FlyBaseID: FBgn0037690
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_002236.1
• Gene: KCNK1 / 3775
• HGNCID: 6272
• Length: 336
• Species: Homo sapiens
• Alignment Length: 281
• Identity: 78/281 - (27%)
• Similarity: 129/281 - (45%)
• Gaps: 49/281 - (17%)

  Fly    12 LVVCTFTYLLIGAAVFDSLESPTEAKRWEFLQTVKNNFVRKYNVTDED------FRVME-----I 65
            ||:....||:.||.||.|:|.|.|....:.|:.:|..|:.::....|.      .||:|     :
Human    26 LVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFLEEHECLSEQQLEQFLGRVLEASNYGV 90

  Fly    66 VIIENKPHKAGPQWKFAGAFYFSTVVLAMIGYGHSTPVTIPGKAFCMGYAMVGIPLGLVMFQSIG 130
            .::.|.  .....|.|..|.:|::.||:..||||:.|::..|||||:.|:::|||..|:...::.
Human    91 SVLSNA--SGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVV 153

  Fly   131 ERLNKFASVIIRRAKRASGARCTDATEMNLMLATGMLSSIIIT----TGAAVFSRYE-GWSYFDS 190
            :|:...   :.||.......|...:.::..::...:|..:.::    ..|||||..| .|::.:|
Human   154 QRITVH---VTRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLES 215

  Fly   191 FYYCFVTLTTIGFGDYVALQNDQALTNKPG-----------------YVALSLVFILFGLAVVAA 238
            ||:||::|:|||.||||           ||                 |:.|.|:.:|..|.....
Human   216 FYFCFISLSTIGLGDYV-----------PGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCE 269

  Fly   239 SINLLVLRFMTMQAEDAKRDE 259
            ...|...|.|....:|...|:
Human   270 LHELKKFRKMFYVKKDKDEDQ 290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Task7	NP_649891.1	Ion_trans_2	<74..133	CDD:462301	21/58 (36%)
		Ion_trans_2	166..244	CDD:462301	29/99 (29%)
KCNK1	NP_002236.1	Ion_trans_2	<98..157	CDD:462301	22/58 (38%)
		pore-forming domain	107..123		7/15 (47%)
		Ion_trans_2	191..267	CDD:462301	27/86 (31%)
		pore-forming domain	212..238		15/36 (42%)
		Important for intracellular retention in recycling endosomes. /evidence=ECO:0000269|PubMed:19959478	293..299