Protein Alignment Task7 and KCNA4

DIOPT Version :10

• Sequence 1: NP_649891.1
• Gene: Task7 / 41125
• FlyBaseID: FBgn0037690
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_002224.1
• Gene: KCNA4 / 3739
• HGNCID: 6222
• Length: 653
• Species: Homo sapiens
• Alignment Length: 144
• Identity: 35/144 - (24%)
• Similarity: 62/144 - (43%)
• Gaps: 28/144 - (19%)

  Fly   140 IIRRAKRASGARCTDATEMNLMLATGML-----SSIIITTGAAVFSRY-EGWSYF----DSFYYC 194
            |.:.::.:.|.:....|....|...|:|     ..:|:.:.|..|:.. |..::|    |:|::.
Human   454 IFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWA 518

  Fly   195 FVTLTTIGFGDYVALQNDQALTNKP----GYVALSLVFILFGLAVVAASINLLVLRFMTMQAEDA 255
            .||:||:|:||.           ||    |.:..||..|. |:..:|..:.::|..|......:.
Human   519 VVTMTTVGYGDM-----------KPITVGGKIVGSLCAIA-GVLTIALPVPVIVSNFNYFYHRET 571

  Fly   256 KRDEQDAQNLAGNA 269
            :.:||  ..|..||
Human   572 ENEEQ--TQLTQNA 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Task7	NP_649891.1	Ion_trans_2	<74..133	CDD:462301
		Ion_trans_2	166..244	CDD:462301	23/91 (25%)
KCNA4	NP_002224.1	K_channel_TID	1..>37	CDD:429748
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..148
		BTB_POZ	176..303	CDD:453885
		Ion_trans	306..570	CDD:459842	30/127 (24%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	462..475		2/12 (17%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	524..529		2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	629..653
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P15385	651..653