Protein Alignment Task7 and KCNA2

DIOPT Version :10

• Sequence 1: NP_649891.1
• Gene: Task7 / 41125
• FlyBaseID: FBgn0037690
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_004965.1
• Gene: KCNA2 / 3737
• HGNCID: 6220
• Length: 499
• Species: Homo sapiens
• Alignment Length: 206
• Identity: 47/206 - (22%)
• Similarity: 80/206 - (38%)
• Gaps: 49/206 - (23%)

  Fly   140 IIRRAKRASGARCTDATEMNLMLATGML-----SSIIITTGAAVFSRY-EGWSYF----DSFYYC 194
            |.:.::.:.|.:....|....|...|:|     ..:|:.:.|..|:.. |..|.|    |:|::.
Human   304 IFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWA 368

  Fly   195 FVTLTTIGFGDYVALQNDQALTNKPGYVALSLVFILFGLAVVAASINLLVLRFMTMQAEDAKRDE 259
            .|::||:|:||.|.       |...|.:..||..|. |:..:|..:.::|..|......:.:.:|
Human   369 VVSMTTVGYGDMVP-------TTIGGKIVGSLCAIA-GVLTIALPVPVIVSNFNYFYHRETEGEE 425

  Fly   260 QDAQNL----------------AGNAQPVTFDD-----ESTYNMHGKLLENNYTTENDETASLCS 303
            | ||.|                :.:|..::..|     |...|.:....|.|..|.|
Human   426 Q-AQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTAN-------- 481

  Fly   304 CTCMGGTRCLN 314
            || :..|..:|
Human   482 CT-LANTNYVN 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Task7	NP_649891.1	Ion_trans_2	<74..133	CDD:462301
		Ion_trans_2	166..244	CDD:462301	23/87 (26%)
KCNA2	NP_004965.1	Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P63142	1..125
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		BTB_POZ	33..159	CDD:453885
		Ion_trans	162..420	CDD:459842	30/123 (24%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	312..325		2/12 (17%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		2/4 (50%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P63142	497..499