DRSC/TRiP Functional Genomics Resources

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Protein Alignment Task7 and KCNA1

DIOPT Version :10

Sequence 1:NP_649891.1 Gene:Task7 / 41125 FlyBaseID:FBgn0037690 Length:340 Species:Drosophila melanogaster
Sequence 2:NP_000208.2 Gene:KCNA1 / 3736 HGNCID:6218 Length:495 Species:Homo sapiens


Alignment Length:375 Identity:75/375 - (20%)
Similarity:133/375 - (35%) Gaps:106/375 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LVVCTFTYLLIGAAVFDSLESPTEAK-RWEFLQTVK--NNFVRKYN---VTDEDFRVMEIVIIEN 70
            :.:.:...:||...:| .||:..|.| ..:|..||.  :|....||   .||..|.|..:.||  
Human   169 IAIVSVMVILISIVIF-CLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCII-- 230

  Fly    71 KPHKAGPQWKFAGAFYFSTVV---------------------LAMIGYGHSTPVTIPGKAFCMGY 114
                    |     |.|..||                     :|:|.|                :
Human   231 --------W-----FSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPY----------------F 266

  Fly   115 AMVGIPLGLVMFQSIGERLNKFASV----------IIRRAKRASGARCTDATEMNLMLATGML-- 167
            ..:|..:........||:....|.:          |.:.::.:.|.:....|....|...|:|  
Human   267 ITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIF 331

  Fly   168 ---SSIIITTGAAVFSR-YEGWSYF----DSFYYCFVTLTTIGFGDYVALQNDQALTNKPGYVAL 224
               ..:|:.:.|..|:. .|..|:|    |:|::..|::||:|:||...:       ...|.:..
Human   332 FLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPV-------TIGGKIVG 389

  Fly   225 SLVFILFGLAVVAASINLLVLRFMTMQAEDAKRDEQDAQNLAGNAQPVTFDDESTYNMHGKLLEN 289
            ||..|. |:..:|..:.::|..|......:.:.:|| ||.|..::..:..|.:.:......:.::
Human   390 SLCAIA-GVLTIALPVPVIVSNFNYFYHRETEGEEQ-AQLLHVSSPNLASDSDLSRRSSSTMSKS 452

  Fly   290 NY-TTENDETASL----------CSCTCMGGTRCLNHEQFVDPDFQPTDI 328
            .| ..|.|...|:          .:|| .....|:|..:.:      ||:
Human   453 EYMEIEEDMNNSIAHYRQVNIRTANCT-TANQNCVNKSKLL------TDV 495

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Task7NP_649891.1 Ion_trans_2 <74..133 CDD:462301 11/79 (14%)
Ion_trans_2 166..244 CDD:462301 21/87 (24%)
KCNA1NP_000208.2 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499 1..128
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
BTB_POZ 37..163 CDD:453885
Ion_trans 166..418 CDD:459842 59/288 (20%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 2/12 (17%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 2/4 (50%)
PDZ-binding. /evidence=ECO:0000250 493..495 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

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