DRSC/TRiP Functional Genomics Resources

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Protein Alignment Task7 and Kcnd2

DIOPT Version :10

Sequence 1:NP_649891.1 Gene:Task7 / 41125 FlyBaseID:FBgn0037690 Length:340 Species:Drosophila melanogaster
Sequence 2:NP_062671.1 Gene:Kcnd2 / 16508 MGIID:102663 Length:630 Species:Mus musculus


Alignment Length:387 Identity:80/387 - (20%)
Similarity:132/387 - (34%) Gaps:145/387 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 TLSLVVCTFTYLLIGAAVFDSLESPTEAKRWEFLQTV-------------------KNNFVRKYN 54
            |..:::.|..|||..||      :|:   |:.|:::|                   .|..|....
Mouse   234 TACVMIFTVEYLLRLAA------APS---RYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAF 289

  Fly    55 VTDEDFRVMEIVIIENKPHKAGPQWKFAGAFYFSTVVLAMIGYGHSTPVTIPGKAFCMGYAMVGI 119
            ||...|||..  |.:...|..|               |.::||      |:...|..:|:.:..:
Mouse   290 VTLRVFRVFR--IFKFSRHSQG---------------LRILGY------TLKSCASELGFLLFSL 331

  Fly   120 PLGLVMFQSIGERLNKFASVIIRRAKRASGARCTDATEMNLMLATGMLSSIIITTGAAVFSRYEG 184
            .:.:::          ||:|:....|.:|.::.|                               
Mouse   332 TMAIII----------FATVMFYAEKGSSASKFT------------------------------- 355

  Fly   185 WSYFDSFYYCFVTLTTIGFGDYVALQNDQALTNKPGYVA---LSLVFILFGLAVVAASINLLVLR 246
             |...:|:|..||:||:|:||.|           |..:|   ...:..|.|:.|:|..:.::|..
Mouse   356 -SIPAAFWYTIVTMTTLGYGDMV-----------PKTIAGKIFGSICSLSGVLVIALPVPVIVSN 408

  Fly   247 FMTMQAEDAKRDEQDAQNLAGNAQPVTFDDESTYN--MHGK---LLENNYTTENDETASLCSCTC 306
            |..:..::.:.|::.||..|..|: :......:.|  |..|   ||.|...:..||.|.:.....
Mouse   409 FSRIYHQNQRADKRRAQKKARLAR-IRAAKSGSANAYMQSKRNGLLSNQLQSSEDEPAFISKSGS 472

  Fly   307 MGGTR------CL----NHEQFVD---------------------PDFQPTDIIESTLCLKR 337
            ...|:      ||    ||| |||                     |.......:.||.|.:|
Mouse   473 SFETQHHHLLHCLEKTTNHE-FVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRR 533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Task7NP_649891.1 Ion_trans_2 <74..133 CDD:462301 7/58 (12%)
Ion_trans_2 166..244 CDD:462301 17/80 (21%)
Kcnd2NP_062671.1 Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881 2..20
BTB_POZ 6..144 CDD:453885
Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q63881 71..90
Ion_trans 184..415 CDD:459842 52/265 (20%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 308..321 5/33 (15%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 370..375 2/4 (50%)
DUF3399 470..546 CDD:463381 14/65 (22%)
Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000250|UniProtKB:Q63881 474..630 14/61 (23%)
Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 474..489 3/14 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 600..623
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q63881 627..630
Blue background indicates that the domain is not in the aligned region.

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