Protein Alignment Task7 and Kcnk6

DIOPT Version :10

• Sequence 1: NP_649891.1
• Gene: Task7 / 41125
• FlyBaseID: FBgn0037690
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_446258.2
• Gene: Kcnk6 / 116491
• RGDID: 621450
• Length: 313
• Species: Rattus norvegicus
• Alignment Length: 272
• Identity: 75/272 - (27%)
• Similarity: 129/272 - (47%)
• Gaps: 48/272 - (17%)

  Fly     4 RQNVRTLSLVVCTFTYLLIGAAVFDSLESPTEAKRWEFLQTVKNNFVR-----KYNVTDEDFRVM 63
            |:.....|.:|....||.:||.:...||.|.||:....|.|::...:|     ..:..|   ..:
  Rat     2 RRGALLASALVAYAGYLALGALLVARLERPHEARLRAELGTLREQLLRHSPCVAAHALD---AFV 63

  Fly    64 EIVIIENKPHKA------------GPQWKFAGAFYFSTVVLAMIGYGHSTPVTIPGKAFCMGYAM 116
            |.|:...:..:|            .|.|.||.|.:|::.::..:|||::||:|..||||.:.:|:
  Rat    64 ERVLAAGRLGRAVLANASGPANASDPAWDFASALFFASTLVTTVGYGYTTPLTDAGKAFSIVFAL 128

  Fly   117 VGIPLGLVMFQSIGERLNKFASVIIRRAKRA-----SGARCTDATEMNLMLATGMLSSIIITTGA 176
            :|:|:.:::..:..:||    |:::..|..:     .|.....|...:|:....::.:|.....|
  Rat   129 LGVPITMLLLTASAQRL----SLLLTHAPLSWLSLRWGWHPQRAARWHLVALLMVIVAIFFLIPA 189

  Fly   177 AVFSRY-EGWSYFDSFYYCFVTLTTIGFGDYVALQNDQALTNKPG------YVALSLVFILFGLA 234
            |||:.. |.||:.|:||:||::|:|||.||||.       ...||      |..|...::..||.
  Rat   190 AVFAYLEEAWSFLDAFYFCFISLSTIGLGDYVP-------GEAPGQPYRSLYKVLVTAYLFLGLV 247

  Fly   235 VVAASINLLVLR 246
            .:     :|||:
  Rat   248 AM-----VLVLQ 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Task7	NP_649891.1	Ion_trans_2	<74..133	CDD:462301	20/70 (29%)
		Ion_trans_2	166..244	CDD:462301	27/84 (32%)
Kcnk6	NP_446258.2	Ion_trans_2	<89..146	CDD:462301	21/60 (35%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	106..111		2/4 (50%)
		Ion_trans_2	180..259	CDD:462301	30/87 (34%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	214..219		3/4 (75%)
		Lysosomal targeting signal. /evidence=ECO:0000269|PubMed:28381826	282..290
		Lysosomal targeting signal. /evidence=ECO:0000269|PubMed:28381826	308..312