DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaTub85D and TUB1

DIOPT Version :9

Sequence 1:	NP_524290.2	Gene:	betaTub85D / 41124	FlyBaseID:	FBgn0003889	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_013625.1	Gene:	TUB1 / 854889	SGDID:	S000004550	Length:	447	Species:	Saccharomyces cerevisiae

Alignment Length:	452	Identity:	185/452 - (40%)
Similarity:	274/452 - (60%)	Gaps:	21/452 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MREIVHIQAGQCGNQIGGKFWEVISDEHCIDATGTYYGDSDLQL-----ERINVYYNEATGAKYV 60
            |||::.|..||.|.|||...||:.|.||.|...|  :.:..|..     |..:.:::|....|:|
Yeast     1 MREVISINVGQAGCQIGNACWELYSLEHGIKPDG--HLEDGLSKPKGGEEGFSTFFHETGYGKFV 63

  Fly    61 PRAILVDLEPGTMDSVRSGAFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESE 125
            ||||.|||||..:|.||:|.:..:|.|:..:.|:..|.||:|:||||.|.|::..|||.:||.::
Yeast    64 PRAIYVDLEPNVIDEVRNGPYKDLFHPEQLISGKEDAANNYARGHYTVGREILGDVLDRIRKLAD 128

  Fly   126 GCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVH 190
            .||.||||..|||||||||||:|:||:.::..||..:....|:|.|:|:||.:||||||..|:.|
Yeast   129 QCDGLQGFLFTHSLGGGTGSGLGSLLLEELSAEYGKKSKLEFAVYPAPQVSTSVVEPYNTVLTTH 193

  Fly   191 QLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAV 255
            ..:|:.|.|:.:||||:||:|.|.|.:..|::.:||:|::..:|.||..|||.|.||.||.:...
Yeast   194 TTLEHADCTFMVDNEAIYDMCKRNLDIPRPSFANLNNLIAQVVSSVTASLRFDGSLNVDLNEFQT 258

  Fly   256 NMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGR 320
            |:||:||:||.:..::|:.|:....:.:.:|.|:|...|:..|.|..||||.|:|:....::||.
Yeast   259 NLVPYPRIHFPLVSYSPVLSKSKAFHESNSVSEITNACFEPGNQMVKCDPRDGKYMATCLLYRGD 323

  Fly   321 MSMKEVDEQMLNIQNKNSSFFVEWIPNNCKTAVCDIPPRGLKMS--AT------FIGNSTAIQEL 377
            :..::|...:..::||.:...|:|.|...|..:|..||.....|  ||      .:.|:|:|.|.
Yeast   324 VVTRDVQRAVEQVKNKKTVQLVDWCPTGFKIGICYEPPTATPNSQLATVDRAVCMLSNTTSIAEA 388

  Fly   378 FKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATAD---EEGEF 436
            :||:..:|..|:.::||:|||.||||:|.|||||.   .||.:..:.|.|..||   ||.||
Yeast   389 WKRIDRKFDLMYAKRAFVHWYVGEGMEEGEFTEAR---EDLAALERDYIEVGADSYAEEEEF 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaTub85D	NP_524290.2	PLN00220	1..430	CDD:215107	179/441 (41%)
TUB1	NP_013625.1	alpha_tubulin	2..436	CDD:276955	177/438 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810