DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaTub85D and TUB2

DIOPT Version :9

Sequence 1:	NP_524290.2	Gene:	betaTub85D / 41124	FlyBaseID:	FBgn0003889	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_116616.1	Gene:	TUB2 / 850506	SGDID:	S000001857	Length:	457	Species:	Saccharomyces cerevisiae

Alignment Length:	446	Identity:	333/446 - (74%)
Similarity:	395/446 - (88%)	Gaps:	0/446 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MREIVHIQAGQCGNQIGGKFWEVISDEHCIDATGTYYGDSDLQLERINVYYNEATGAKYVPRAIL 65
            ||||:||..||||||||..|||.|..||.:|..|||:|..|:|.||:|||:|||:..|:|||:|.
Yeast     1 MREIIHISTGQCGNQIGAAFWETICGEHGLDFNGTYHGHDDIQKERLNVYFNEASSGKWVPRSIN 65

  Fly    66 VDLEPGTMDSVRSGAFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESEGCDCL 130
            |||||||:|:||:.|.|.:|||||::||||.|||.||||||||||||||||:||:|:|:||||.|
Yeast    66 VDLEPGTIDAVRNSAIGNLFRPDNYIFGQSSAGNVWAKGHYTEGAELVDSVMDVIRREAEGCDSL 130

  Fly   131 QGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVEN 195
            ||||:|||||||||||||||||||||||:|||:|.||||:||||.|||||||||||||||||||:
Yeast   131 QGFQITHSLGGGTGSGMGTLLISKIREEFPDRMMATFSVLPSPKTSDTVVEPYNATLSVHQLVEH 195

  Fly   196 TDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPF 260
            :|||:|||||||||||.|||||..|:|||||:|||:.||||||.||:|||||:||||||||:|||
Yeast   196 SDETFCIDNEALYDICQRTLKLNQPSYGDLNNLVSSVMSGVTTSLRYPGQLNSDLRKLAVNLVPF 260

  Fly   261 PRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKE 325
            |||||||.|:||||:.|||.:|:|||||||||||||||||||.|||:||||||||.|||::|:||
Yeast   261 PRLHFFMVGYAPLTAIGSQSFRSLTVPELTQQMFDAKNMMAAADPRNGRYLTVAAFFRGKVSVKE 325

  Fly   326 VDEQMLNIQNKNSSFFVEWIPNNCKTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFR 390
            |:::|..:|:|||.:||||||||.:||||.:.|:||.|:||||.|||:||||||||.:||:|||:
Yeast   326 VEDEMHKVQSKNSDYFVEWIPNNVQTAVCSVAPQGLDMAATFIANSTSIQELFKRVGDQFSAMFK 390

  Fly   391 RKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATADEEGEFDEDEEGGGDE 446
            |||||||||.|||||:||:||||||||||||||||||||.:::.|.||:.:.|..:
Yeast   391 RKAFLHWYTSEGMDELEFSEAESNMNDLVSEYQQYQEATVEDDEEVDENGDFGAPQ 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaTub85D	NP_524290.2	PLN00220	1..430	CDD:215107	328/428 (77%)
TUB2	NP_116616.1	beta_tubulin	2..426	CDD:276956	323/423 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	349	1.000	Domainoid score	I143
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	715	1.000	Inparanoid score	I88
Isobase	1	0.950	-	0	Normalized mean entropy	S24
OMA	1	1.010	-	-		QHG53784
OrthoFinder	1	1.000	-	-		FOG0000096
OrthoInspector	1	1.000	-	-		otm46719
orthoMCL	1	0.900	-	-		OOG6_100137
Panther	1	1.100	-	-	O	PTHR11588
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X99
TreeFam	0	0.000	Not matched by this tool.
	12	11.820