DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaTub85D and Tuba3b

DIOPT Version :9

Sequence 1:	NP_524290.2	Gene:	betaTub85D / 41124	FlyBaseID:	FBgn0003889	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_001019507.1	Gene:	Tuba3b / 500363	RGDID:	1565155	Length:	450	Species:	Rattus norvegicus

Alignment Length:	456	Identity:	183/456 - (40%)
Similarity:	268/456 - (58%)	Gaps:	22/456 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MREIVHIQAGQCGNQIGGKFWEVISDEHCIDATG------TYYGDSDLQLERINVYYNEATGAKY 59
            |||.:.|..||.|.|||...||:...||.|...|      |..|..|    ..|.:::|....|:
  Rat     1 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDD----SFNTFFSETGAGKH 61

  Fly    60 VPRAILVDLEPGTMDSVRSGAFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKES 124
            ||||:.|||||..:|.||:|.:.|:|.|:..:.|:..|.||:|:||||.|.|:||.|||.:||.:
  Rat    62 VPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLA 126

  Fly   125 EGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSV 189
            :.|..||||.:.||.|||||||..:||:.::..:|..:....|::.|:|:||..||||||:.|:.
  Rat   127 DLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTT 191

  Fly   190 HQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLA 254
            |..:|::|..:.:||||:||||.|.|.:..|||.:||.|:...:|.:|..|||.|.||.||.:..
  Rat   192 HTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQ 256

  Fly   255 VNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRG 319
            .|:||:||:||.:..:||:.|.....:..|:|.|:|...|:..|.|..||||||:|:....::||
  Rat   257 TNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRG 321

  Fly   320 RMSMKEVDEQMLNIQNKNSSFFVEWIPNNCKTAVCDIPP--------RGLKMSATFIGNSTAIQE 376
            .:..|:|:..:..|:.|.:..||:|.|...|..:...||        ..::.:...:.|:|||.|
  Rat   322 DVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAE 386

  Fly   377 LFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATADE-EGEFDEDE 440
            .:.|:..:|..|:.::||:|||.||||:|.||:||.   .||.:..:.|:|...|. |.|.:|.|
  Rat   387 AWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAR---EDLAALEKDYEEVGVDSVEAEAEEGE 448

  Fly   441 E 441
            |
  Rat   449 E 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaTub85D	NP_524290.2	PLN00220	1..430	CDD:215107	177/442 (40%)
Tuba3b	NP_001019507.1	PTZ00335	1..440	CDD:185562	178/445 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900