DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaTub85D and Tube1

DIOPT Version :9

Sequence 1:	NP_524290.2	Gene:	betaTub85D / 41124	FlyBaseID:	FBgn0003889	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	XP_006256590.1	Gene:	Tube1 / 361856	RGDID:	1306048	Length:	475	Species:	Rattus norvegicus

Alignment Length:	468	Identity:	147/468 - (31%)
Similarity:	237/468 - (50%)	Gaps:	60/468 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MREIVHIQAGQCGNQIGGKFWEVISDEHCI--------DATGTYYGDSDLQLERINVYYNEATG- 56
            |.:.|.:|.||||||||..||::...||..        ||..:::.:.|          ..|.|
  Rat     1 MTQSVVVQVGQCGNQIGCCFWDLALREHAAVNQKGIYDDAISSFFRNVD----------TRAVGD 55

  Fly    57 ---------AKYVPRAILVDLEPGTMDSVRSGAFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAEL 112
                     :....||:|:|:|.|.::.:..|....:|.....:...||:|||||.||...|:..
  Rat    56 CGSISKGRISSLKARAVLIDMEEGVVNEILQGPLRDVFDSKQLITDISGSGNNWAVGHKVFGSLY 120

  Fly   113 VDSVLDVVRKESEGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSD 177
            .:.:|:.:||.:|.|||||.|.:.||:|||||||:||.|:..:.:|:|:......:|.||.: .|
  Rat   121 REQILEKLRKSAEHCDCLQCFFIIHSMGGGTGSGLGTFLLKVLEDEFPEVYRFVTAVYPSSE-DD 184

  Fly   178 TVVEPYNATLSVHQLVENTDETYCIDNEALYDI---------------CFRTLKLTTPTYGD--- 224
            .:..|||:.|::.:|.|:.|....|||::|:||               ..:...|.|...|.
  Rat   185 VITSPYNSMLAMKELSEHADCVLPIDNQSLFDIISKIDLVVNSGKLGSAVKPKSLITSNTGPVKK 249

  Fly   225 --------LNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQY 281
                    :|::|:..:..:|:..||.|.||.||.::::|:||||:||:.:....||.:......
  Rat   250 RHKKPFDAMNNIVANLLLSLTSSARFEGSLNMDLNEISMNLVPFPQLHYLVSSLTPLYTLADVNI 314

  Fly   282 RALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNIQN-KNSSFFVEWI 345
            ....:.::....|...:.:...|||||.||..|.|.||.:   ::.:...||:. |.:..||.|.
  Rat   315 PPRRLDQMFSDAFSKGHQLLQADPRHGLYLACALIVRGEV---QISDLRRNIERLKPALQFVSWN 376

  Fly   346 PNNCKTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFRRKAFLHWYTG-EGMDEMEFT 409
            ....||::|.:||.|...|...:.|:|.::..|..:.|:|..::::||.||.|.. :||:|..||
  Rat   377 QEGWKTSLCSVPPVGHPHSLLALANNTCVKPTFLELRERFMRLYKKKAHLHHYLQVDGMEESTFT 441

  Fly   410 EAESNMNDLVSEY 422
            ||.|:::.|:.||
  Rat   442 EAVSSLSALIQEY 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaTub85D	NP_524290.2	PLN00220	1..430	CDD:215107	147/468 (31%)
Tube1	XP_006256590.1	PTZ00387	1..470	CDD:240395	147/468 (31%)
Tube1	XP_006256590.1	epsilon_tubulin	2..457	CDD:276959	146/467 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810