DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaTub85D and tuba4l

DIOPT Version :9

Sequence 1:	NP_524290.2	Gene:	betaTub85D / 41124	FlyBaseID:	FBgn0003889	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_956089.1	Gene:	tuba4l / 327377	ZFINID:	ZDB-GENE-030131-5588	Length:	449	Species:	Danio rerio

Alignment Length:	450	Identity:	179/450 - (39%)
Similarity:	270/450 - (60%)	Gaps:	12/450 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MREIVHIQAGQCGNQIGGKFWEVISDEHCIDATGTYYGDS-DLQLERINVYYNEATGAKYVPRAI 64
            |||.:.|..||.|.|:|...||:...||.....||....| .|.......:::|....||||||:
Zfish     1 MRECISIHIGQAGIQMGNSCWELYCLEHGFQPDGTIVDSSRSLADSSFGTFFSETGAGKYVPRAV 65

  Fly    65 LVDLEPGTMDSVRSGAFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESEGCDC 129
            .:||||..:|.:|:|.:.|::.|:..:.|:..|.||:|:||||.|.|:||||||.:||.::.|..
Zfish    66 FIDLEPTVVDEIRNGHYRQLYHPEQLISGKEDAANNYARGHYTIGKEIVDSVLDRMRKMADQCTG 130

  Fly   130 LQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVE 194
            ||||.:.||.|||||||..:||:.::..:|..:....|||.|:|:||..||||||:.|:.|..:|
Zfish   131 LQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSVYPAPQVSTAVVEPYNSILTTHTTLE 195

  Fly   195 NTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVP 259
            ::|.::.:||||::|||.|.|.:..|:|.:||.|::..:|.:|..|||.|.||.||.:...|:||
Zfish   196 HSDCSFMVDNEAIFDICKRNLDIERPSYTNLNRLIAQIVSSITASLRFDGALNVDLTEFQTNLVP 260

  Fly   260 FPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMK 324
            :||:||.:..::|:.|.....:..|:|||:|...|:..|.|..||||.|:|:....::||.:..|
Zfish   261 YPRIHFPLVTYSPIISAEKAYHEQLSVPEITNACFEPANQMVKCDPRRGKYMACCLLYRGDVVPK 325

  Fly   325 EVDEQMLNIQNKNSSFFVEWIPNNCKTAVCDIPP--------RGLKMSATFIGNSTAIQELFKRV 381
            :|:..:.||:.:.|..||:|.|...|..:...||        ..::.:...:.|:|||.|.:.|:
Zfish   326 DVNAAIANIKTRRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWGRL 390

  Fly   382 SEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATADEEGEFDEDEE 441
            ..:|..|:.::||:|||.||||:|.||:||..:|..|..:   |:|..||...:..||||
Zfish   391 DHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKD---YEEVAADSTDDCGEDEE 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaTub85D	NP_524290.2	PLN00220	1..430	CDD:215107	173/437 (40%)
tuba4l	NP_956089.1	PTZ00335	1..449	CDD:185562	178/449 (40%)
tuba4l	NP_956089.1	alpha_tubulin	2..434	CDD:276955	171/434 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900