DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8135 and Lmbrd2

DIOPT Version :9

Sequence 1:	NP_649890.1	Gene:	CG8135 / 41123	FlyBaseID:	FBgn0037689	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_796152.2	Gene:	Lmbrd2 / 320506	MGIID:	2444173	Length:	694	Species:	Mus musculus

Alignment Length:	733	Identity:	313/733 - (42%)
Similarity:	437/733 - (59%)	Gaps:	87/733 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LSFGIVAALFLASISLYRYGNIPRQHILVTLSVLTAWCFSFLIVFTIPLDVTSTLYRQCVEEHRP 69
            |...||...|||...|:|||:..:||.||.:..|.||...|||||.:||||::|:|.:|......
Mouse     6 LGLEIVFVFFLALFLLHRYGDFKKQHRLVIIGTLLAWYLCFLIVFILPLDVSTTIYNRCRHAAAN 70

  Fly    70 TPAPNVTNTS--SATVGPPPQ---CQEPWGMVPASVFPNLWRIIYWSSQFLTWLIMPLMQSYLKA 129
            :..|..||.:  .|:|.|.|:   |.:||..:|..:.|..||::||:||||||:::|.||||.::
Mouse    71 SSPPENTNVTGLDASVTPAPRQHPCFKPWSYIPDGIMPIFWRVVYWTSQFLTWILLPFMQSYARS 135

  Fly   130 GDFTVKGKLKSALIENAIYYGSYLFICGVLLIYIAVKGE-SLDWQKLKAIASSASNTWGLFLLIL 193
            |.|::.||:|:||||||||||:||.|.|..|||:||... .|:|.:|:.|..:|:||||||||:|
Mouse   136 GGFSITGKIKTALIENAIYYGTYLLIFGAFLIYVAVNPRLHLEWNQLQTIGIAAANTWGLFLLVL 200

  Fly   194 LLGYALVEVPRSLWNNAKPGFALQYAYFKAAKLSTEKAEAEEHVDDILESLQGLSRVIPNNHELR 258
            ||||.|||:|||.||.||.|:.|...|||||||.||||:|||:::|::|.::.::..|..||.||
Mouse   201 LLGYGLVEIPRSYWNGAKRGYLLMKTYFKAAKLMTEKADAEENLEDVMEEVRKVNESIKYNHPLR 265

  Fly   259 PCLETILRKVPIELQERASRN------FARTGGSGMGATSSTILPSEKALVRIHKQVIKSLQTLQ 317
            .|::|||:|.|.:.||:..||      |..         .....||||:||::|||||.|:|..:
Mouse   266 KCVDTILKKCPTDYQEKMGRNMDDYEDFDE---------KRNTYPSEKSLVKLHKQVIYSVQRHR 321

  Fly   318 RTEALWSVQVQTVLHLEDVAKNIHSSDRRFKSEF--PRQRTQLERICYSASLQWYWECLLKAPFL 380
            ||:..|.:.::...:|||||||..|:..:|...|  |....:..:..|:.:::|||||||:..|.
Mouse   322 RTQVQWQILLEQAFYLEDVAKNETSATHQFVHTFQSPEPENRFIQYFYNPTVEWYWECLLRPWFH 386

  Fly   381 KTMCVLTATMSAMVVWSELTFFSRHPVLSIFANVIYVAKESYDFFTIEVFSMVVLCYFFYCTYST 445
            :|:.|:.:..|.:|||||.||||..||||:||..|.:|:.:|::..||:...:.:.:...|.|||
Mouse   387 RTLAVVLSIFSVIVVWSECTFFSTTPVLSLFAVFIQLAERTYNYIYIEIACFLSIFFLSICVYST 451

  Fly   446 ILRIRFLNLYYLAPHHQTNEHSLIFSGMLLCRLTPPMCLNFLGLIHMDTHIIPNRIMETVYTQIM 510
            :.|||..|.||||.||||:.:||:|||||.||||||:|||||||.|||:.|.......|.||.||
Mouse   452 VFRIRVFNYYYLASHHQTDAYSLLFSGMLFCRLTPPLCLNFLGLTHMDSSISHQNTQPTAYTSIM 516

  Fly   511 GHMDVIGIISNGFNIYFPMCMLAFCLATWFSLGSRALNALGFQQFLQNETIATELVQEGKDLIAR 575
            |.|.|:..|::||.||:||.::..|:||:||||:|.||.||||||:.:..:.::||.|||:||.|
Mouse   517 GSMKVLSFIADGFYIYYPMLVVILCIATYFSLGTRCLNLLGFQQFMGDNDMTSDLVDEGKELIRR 581

  Fly   576 EKRRRQRAEEAMARRRDF------NRTDQVLG----------------SDYLSKYRSGGPGGLTS 618
            |||:|||.||...|||::      ||.|....                :::.|||..      .:
Mouse   582 EKRKRQRQEEGENRRREWKERYGHNREDSTRNRNVHPDPKESNFSDTTTNWSSKYTR------AN 640

  Fly   619 SRTPAD--GLLRDGDGSFDYAAVASSSALGVPRSLSEEINDRFGVSTQVQVGFRDPDYEAET--- 678
            :||..|  .||:|.:                |...:.|.             |.|...|.|:
Mouse   641 NRTERDRIELLQDAE----------------PLDFNAET-------------FTDESLEPESGRY 676

  Fly   679 --DGRIVGPPPRGLFDDV 694
              .||.:......:|:|:
Mouse   677 QPGGRYLSMSSSIIFEDI 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8135	NP_649890.1	LMBR1	7..540	CDD:282625	258/546 (47%)
Lmbrd2	NP_796152.2	LMBR1	1..549	CDD:368121	261/551 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..638		17/55 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..680		7/55 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838186
Domainoid	1	1.000	535	1.000	Domainoid score	I279
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44696
Inparanoid	1	1.050	591	1.000	Inparanoid score	I985
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53885
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004974
OrthoInspector	1	1.000	-	-		oto93345
orthoMCL	1	0.900	-	-		OOG6_101796
Panther	1	1.100	-	-	LDO	PTHR21355
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1742
SonicParanoid	1	1.000	-	-		X3508
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.930