DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9356 and BLZF1

DIOPT Version :9

Sequence 1:	NP_649889.1	Gene:	CG9356 / 41122	FlyBaseID:	FBgn0037688	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001307902.1	Gene:	BLZF1 / 8548	HGNCID:	1065	Length:	400	Species:	Homo sapiens

Alignment Length:	439	Identity:	111/439 - (25%)
Similarity:	168/439 - (38%)	Gaps:	100/439 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TDKSQACRTSGDGMEQPENSGAAKTESEIPASADVDNKVKRPQLSRKDSSVVQEAVMGRKTSTSS 75
            |..|...|.:|||||         || |.|.|.:|.:.|:    |||..|:...   .:|...|.
Human    11 TVTSSPIRGAGDGME---------TE-EPPKSVEVTSGVQ----SRKHHSLQSP---WKKAVPSE 58

  Fly    76 GHSSNLPLPG---LHTLYRRPENVTRSLAPVVPKGELVQMRPRLVTSADSLPEHKKTKAPKFVPY 137
            .       ||   |..:........:::..:|||..:....|...|...||..||    .:|:..
Human    59 S-------PGVLQLGKMLTEKAMEVKAVRILVPKAAITHDIPNKNTKVKSLGHHK----GEFLGQ 112

  Fly   138 EPYPGAVNPMISEPTNKHKIHRDKNNLDIAVLVDQVSTLRTQELETETTDIKETDTASSHEVNSL 202
            .  .|.:.|      ||                             |.:::|..       :..|
Human   113 S--EGVIEP------NK-----------------------------ELSEVKNV-------LEKL 133

  Fly   203 KEELAKMRDERNYFQAQYKFQTQVNSELKSLLVASVGEDLQTRVNLLTEDKLQLARALLDTANNL 267
            |....::..::.....|.:.||:||.|||.|||||||:|||.....|..:|.||.........|.
Human   134 KNSERRLLQDKEGLSNQLRVQTEVNRELKKLLVASVGDDLQYHFERLAREKNQLILENEALGRNT 198

  Fly   268 TTHTEQIEFLAGQCEVWRSKFLASSVMVEELARWKADLTQKNQLLNESTKQLLHATHQIREIQLD 332
            ...:||:|.::.||:|||||||||.||.:||...:|.|.::|:..:.:.:.||....|.|:   :
Human   199 AQLSEQLERMSIQCDVWRSKFLASRVMADELTNSRAALQRQNRDAHGAIQDLLSEREQFRQ---E 260

  Fly   333 MLKQLKFLAKIRFLNLPATDVISLS-AENLNILQRMVLHTGVGIPEETLKLSSASTSPL-----C 391
            |:...|.|.::         ::||. .........:..|:...:.....||:.|..|.|     .
Human   261 MIATQKLLEEL---------LVSLQWGREQTYSPSVQPHSTAELALTNHKLAKAVNSHLLGNVGI 316

  Fly   392 EAEKYAVRALEFISQPLMATDEAIRALFD-------QAQRPHYVQSPAS 433
            ..:|.....:||.|.|.....|.:..:.|       ....|.:..||.:
Human   317 NNQKKIPSTVEFCSTPAEKMAETVLRILDPVTCKESSPDNPFFESSPTT 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9356	NP_649889.1	SMC_prok_B	<156..>333	CDD:274008	52/176 (30%)
BLZF1	NP_001307902.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		20/63 (32%)
		Tankyrase-binding motif	18..22		1/3 (33%)
		SMC_N	<132..250	CDD:330553	46/117 (39%)
		DASH_Hsk3	181..226	CDD:311925	19/44 (43%)
		Essential for interaction with GORASP2. /evidence=ECO:0000269\|PubMed:11739401	394..400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150792
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4074
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1218216at2759
OrthoFinder	1	1.000	-	-		FOG0006490
OrthoInspector	1	1.000	-	-		oto91100
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13066
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3881
SonicParanoid	1	1.000	-	-		X6227
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.840