DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and LRIG2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_055628.1	Gene:	LRIG2 / 9860	HGNCID:	20889	Length:	1065	Species:	Homo sapiens

Alignment Length:	363	Identity:	76/363 - (20%)
Similarity:	136/363 - (37%)	Gaps:	106/363 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   937 CYC-VPSLAASISLSTNRPLYEEEW--FHGVLPREEVV-----RLLNNDGDFLVRETIR------ 987
            |.| :|.|..|     .|.|....|  ..|:||.:..:     ..|:|....|..:|::
Human    47 CSCRIPLLDCS-----RRKLPAPSWRALSGLLPPDTAILDFSHNRLSNWNISLESQTLQEVKMNY 106

  Fly   988 NEESQI-----------VLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTV 1041
            ||.::|           :||:.     |.|:........:|    :.:::.|   ...|.:...:
Human   107 NELTEIPYFGEPTSNITLLSLV-----HNIIPEINAQALQF----YPALESL---DLSSNIISEI 159

  Fly  1042 KSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMT--------L 1098
            |:.:..|..:  :...|||:.:..||   .|.|.:     |.|:.|.|.:...||:        |
Human   160 KTSSFPRMQL--KYLNLSNNRITTLE---AGCFDN-----LSSSLLVVKLNRNRMSMIPPKIFKL 214

  Fly  1099 PDEQKRKFLQEGRILKQYDHPNIVKLI-GICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQ 1162
            |..|   ||:    ||:    |.:|:: |:..|            |...|..|:...||::
Human   215 PHLQ---FLE----LKR----NRIKIVEGLTFQ------------GLDSLRSLKMQRNGIS---- 252

  Fly  1163 MGMCRDAA-AGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQI-PVK 1225
              ..:|.| .|:..:|.....|.:|...|         |...:|:...::.|:..:.:::| |..
Human   253 --KLKDGAFFGLNNMEELELEHNNLTRVN---------KGWLYGLRMLQQLYVSQNAIERISPDA 306

  Fly  1226 WTAPEA-----LNFGKYTSLCDVWSYGILMWEIFSKGD 1258
            |...:.     |::.:.|.|.:....|:.:.|..:.||
Human   307 WEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGD 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	20/109 (18%)
		TyrKc	1063..1311	CDD:197581	46/212 (22%)
		PTKc_Fes_like	1067..1315	CDD:270637	45/208 (22%)
LRIG2	NP_055628.1	LRR_RI	<46..205	CDD:238064	39/184 (21%)
		LRR 1	76..97		3/20 (15%)
		LRR 2	98..119		4/20 (20%)
		leucine-rich repeat	99..121	CDD:275380	3/21 (14%)
		LRR_8	120..179	CDD:290566	12/72 (17%)
		LRR 3	121..142		4/25 (16%)
		leucine-rich repeat	122..145	CDD:275378	5/31 (16%)
		LRR 4	145..166		3/23 (13%)
		leucine-rich repeat	146..168	CDD:275380	4/24 (17%)
		LRR_8	168..251	CDD:290566	28/115 (24%)
		LRR 5	168..189		7/25 (28%)
		leucine-rich repeat	169..192	CDD:275380	8/32 (25%)
		LRR 6	193..214		4/20 (20%)
		leucine-rich repeat	194..216	CDD:275380	5/21 (24%)
		LRR 7	216..237		9/43 (21%)
		leucine-rich repeat	217..240	CDD:275380	10/45 (22%)
		LRR_8	240..299	CDD:290566	14/73 (19%)
		LRR 8	240..261		6/26 (23%)
		leucine-rich repeat	241..264	CDD:275380	7/28 (25%)
		LRR 9	264..285		5/29 (17%)
		leucine-rich repeat	265..288	CDD:275380	6/31 (19%)
		LRR_RI	266..492	CDD:238064	17/88 (19%)
		LRR 10	288..309		4/20 (20%)
		leucine-rich repeat	289..312	CDD:275380	4/22 (18%)
		LRR_8	312..371	CDD:290566	7/33 (21%)
		LRR 11	312..333		3/20 (15%)
		leucine-rich repeat	313..336	CDD:275380	4/22 (18%)
		LRR 12	336..357		3/9 (33%)
		leucine-rich repeat	337..360	CDD:275380	3/8 (38%)
		LRR_8	359..422	CDD:290566
		LRR 13	360..382
		leucine-rich repeat	361..385	CDD:275380
		LRR 14	387..408
		leucine-rich repeat	388..411	CDD:275380
		LRR 15	411..432
		leucine-rich repeat	412..434	CDD:275380
		LRRCT	445..493	CDD:214507
		Ig	502..598	CDD:299845
		IG	504..598	CDD:214652
		I-set	602..692	CDD:254352
		Ig_1	619..693	CDD:143240
		I-set	696..783	CDD:254352
		Ig	714..783	CDD:299845
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	962..990
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1003..1040
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910