DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and TRIP10

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_006723003.1	Gene:	TRIP10 / 9322	HGNCID:	12304	Length:	649	Species:	Homo sapiens

Alignment Length:	794	Identity:	145/794 - (18%)
Similarity:	264/794 - (33%)	Gaps:	261/794 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LRLMETMKRSIQMKAKCDKEYAISLTAVAQQGLKIDRADEMQGSLIS--KSWRSYMDELDHQAKQ 86
            |.|::...:.::.:.:.::.||..|.::.::.|....|.:...|..|  :|:...:.|::..|.|
Human    22 LDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAKDDPESKFSQQQSFVQILQEVNDFAGQ 86

  Fly    87 FKFNAEQLEV-VCDKLTHLSQDKRKARKAYQEEHAKIAARLNHLTDEVVRKKSEYQKHL-EGYKA 149
            .:..||.|.| ||.:||..||:.::.||.:.:|..:...:|.:...::...|.::::.. |..||
Human    87 RELVAENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKA 151

  Fly   150 LRT--RFEE--NYIKAPSRSGRKLDDVRDKYQKACRKLHL---THNEYVLSITEAIEVEKDFRNV 207
            .:|  |.::  |..||         ||....|:|..:.|:   :.|||...:......:..|...
Human   152 AQTAERLDQDINATKA---------DVEKAKQQAHLRSHMAEESKNEYAAQLQRFNRDQAHFYFS 207

  Fly   208 LLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADKYKEIQKRIDTVIGSINPTEEYGEFTEKY 272
            .:|.:.:..|.:.|      |...:..|.||.|:
Human   208 QMPQIFDKLQDMDE------RRATRLGAGYGLLS------------------------------- 235

  Fly   273 KTSPTTPLLFQFDETLIQDIPGKLQSSTLTVDNLTVDWLRNRLQELEGAVRDCQEKQMKMIEHVN 337
                         |..::.:|                           .:..|.|
Human   236 -------------EAELEVVP---------------------------IIAKCLE---------- 250

  Fly   338 GGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNALRCQEKQKQKLVDMIKCALNEVGCEELP 402
             |..||           :|.:....||                  ..|:::.|......|
Human   251 -GMKVA-----------ANAVDPKNDS------------------HVLIELHKSGFARPG----- 280

  Fly   403 SGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELMRRGGVLTLLRGRGRHFKRKSTPQPA 467
                 |:..|.      ::....|:.|.||  ||..::....      |||.||
Human   281 -----DVEFED------FSQPMNRAPSDSS--LGTPSDGRPE------LRGPGR----------- 315

  Fly   468 TPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQAASVHYLGEEIATSSTN 532
               :|:::..|.|                .|.|.|....|              ||..:.::..|
Human   316 ---SRTKRWPFGK----------------KNKPRPPPLSP--------------LGGPVPSALPN 347

  Fly   533 PPDLTRLRRTQCSMLC-LGEDEEPVVLASPAPLTQLTAAVLTNTNNNHIYADLELDKKKDTSPSP 596
            .|...|..|...::|. :.:..:| .|||...|......|:|. :.:|:..:   .::|......
Human   348 GPPSPRSGRDPLAILSEISKSVKP-RLASFRSLRGSRGTVVTE-DFSHLPPE---QQRKRLQQQL 407

  Fly   597 ECKGEQIQPKKEQIRI-----EINQTAPQNSIDAHLD-RIDE-LNRVLDDRLKRTLQPSDDVNAI 654
            |.:..::|.:.:|...     ::.:..||....|.|: :|.| |:.:  :|||..:|..:  ..:
Human   408 EERSRELQKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAETLSNI--ERLKLEVQKYE--AWL 468

  Fly   655 ESAEENHIQTR-----KLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNIFSNLK 714
            ..||...:..|     :.|:.||........|||. .:|:||..|.:...| .:...:.|::...
Human   469 AEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSN-SASQDTKESSEEPPS-EESQDTPIYTEFD 531

  Fly   715 E-FSKSPLVRMGKNHILNEEQDA--------------------------KRTQPSQHHHSSG--- 749
            | |.:.|...:|....:...:|.                          |:|:.:....|.|
Human   532 EDFEEEPTSPIGHCVAIYHFEDLGPPPPPSQGPARALSLWPRVKTSVLWKKTKGTAGPGSGGKRE 596

  Fly   750 --SDCPTNSSSSSS 761
              :.||..:|.|.|
Human   597 ARATCPPPTSESRS 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	53/229 (23%)
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581
		PTKc_Fes_like	1067..1315	CDD:270637
TRIP10	XP_006723003.1	F-BAR_CIP4-like	5..257	CDD:153337	60/342 (18%)
TRIP10	XP_006723003.1	HR1_CIP4_FNBP1L	395..475	CDD:212018	17/86 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910