DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and RIPK1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001341859.1	Gene:	RIPK1 / 8737	HGNCID:	10019	Length:	671	Species:	Homo sapiens

Alignment Length:	277	Identity:	75/277 - (27%)
Similarity:	130/277 - (46%)	Gaps:	29/277 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1057 ELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNI 1121
            ::.:.|.:....:..|.||.|.....::..|.:.....:.....|.....|:|.:::.:..|..:
Human    11 KMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRV 75

  Fly  1122 VKLIGICVQKQPIMIVMELVLGGSLLTYLR-KNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRD 1185
            |||:|:.:::....:|||.:..|:|:..|: :.|..|:.:.::.:  :...||.||..|..||:|
Human    76 VKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL--EIIEGMCYLHGKGVIHKD 138

  Fly  1186 LAARNCLVDLEHSVKISDFGM----------SREEEEYIVSDGMKQI---PVKWTAPEALN--FG 1235
            |...|.|||.:..:||:|.|:          :.|..|....||..:.   .:.:.|||.||  ..
Human   139 LKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNA 203

  Fly  1236 KYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARER----IDTGYRMPTPKST---PEEMYRLM 1293
            |.|...||:|:.:::|.||:..: ||.   |:...::    |.:|.|......|   |.|:..||
Human   204 KPTEKSDVYSFAVVLWAIFANKE-PYE---NAICEQQLIMCIKSGNRPDVDDITEYCPREIISLM 264

  Fly  1294 LQCWAADAESRPHFDEI 1310
            ..||.|:.|:||.|..|
Human   265 KLCWEANPEARPTFPGI 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	74/271 (27%)
		PTKc_Fes_like	1067..1315	CDD:270637	74/267 (28%)
RIPK1	NP_001341859.1	STKc_RIP1	23..290	CDD:270929	74/265 (28%)
		Interaction with SQSTM1. /evidence=ECO:0000269\|PubMed:10356400	290..582
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..354
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..458
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:11734559, ECO:0000269\|PubMed:29681455	531..547
		Death_RIP1	583..668	CDD:260048
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900