Protein Alignment FER and PIK3R3

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_001290357.1
• Gene: PIK3R3 / 8503
• HGNCID: 8981
• Length: 478
• Species: Homo sapiens
• Alignment Length: 448
• Identity: 93/448 - (20%)
• Similarity: 165/448 - (36%)
• Gaps: 111/448 - (24%)

  Fly   933 MKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNN--DGDFLVRETIRNEESQIVL 995
            |||         :|:||.      :.||:.|.:.||||...|.:  ||.||||:.....:....|
Human    70 MKD---------SSVSLQ------DAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTL 119

  Fly   996 SVCWNGHKHFIVQTTGEGNFRFEGP-PFASIQELIMHQYHSEL-PVTVKSGAILRRPVCR-ERWE 1057
            ::...|:...|.....:|.:.|..| .|.|:.|||.|.:|..| ....|....|..||.| ::.:
Human   120 TLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQ 184

  Fly  1058 LSNDDVVLLERIGR--GNFGDVYKAKLKS----------TKLDVAVKTCRMTLPDEQKRKFLQEG 1110
            |..:|.:  :.:|:  ..:...|:.|.|.          |..::.:|...:...:|..:.|.::.
Human   185 LVKEDNI--DAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQC 247

  Fly  1111 RILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDA------ 1169
            ...:|:....|.:......:|:...|:|              |.:.|.:|  :|...|:
Human   248 HTQEQHSKEYIERFRREGNEKEIERIMM--------------NYDKLKSR--LGEIHDSKMRLEQ 296

  Fly  1170 -----AAGMRYLESK-NCIHRDLAARNCLVDLEHSVKISDFGMSRE-------------EEEYIV 1215
                 |...|.::.| |.|..||.....:.| :|.|.::..|:.::             :|.|.:
Human   297 DLKNQALDNREIDKKMNSIKPDLIQLRKIRD-QHLVWLNHKGVRQKRLNVWLGIKNEDADENYFI 360

  Fly  1216 SDGMKQIP-----------VKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRA 1269
            ::..:.:|           :.....|.|.:||...       ..|:.|...||....|.:.:...
Human   361 NEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDG-------AFLIRESSKKGCYACSVVADGEV 418

  Fly  1270 RERI----DTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVV--DALILRL 1321
            :..:    ..||....|.:....:..|:|           |:.:...|.  |:|.:||
Human   419 KHCVIYSTARGYGFAEPYNLYSSLKELVL-----------HYQQTSLVQHNDSLNVRL 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	28/89 (31%)
		TyrKc	1063..1311	CDD:197581	47/299 (16%)
		PTKc_Fes_like	1067..1315	CDD:270637	48/301 (16%)
PIK3R3	NP_001290357.1	SH2_nSH2_p85_like	76..184	CDD:198195	35/113 (31%)
		PI3K_P85_iSH2	188..347	CDD:293063	30/177 (17%)
		iSH2_PIK3R3	189..349	CDD:214018	30/178 (17%)
		SH2_cSH2_p85_like	368..471	CDD:198184	21/116 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910