DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FER and Jak1

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_445918.1 Gene:Jak1 / 84598 RGDID:69056 Length:1153 Species:Rattus norvegicus


Alignment Length:1138 Identity:238/1138 - (20%)
Similarity:408/1138 - (35%) Gaps:308/1138 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   406 DDDLTLEQNFIENGY------NNEQQRSNSTSSPGLGIMNELMRRGGVLTLLRGRGRHFKRKSTP 464
            ||.::|..::....|      .|:.::|....||      :..:.|            :::|..|
  Rat    98 DDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSP------KKQKNG------------YEKKKVP 144

  Fly   465 QPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQA--ASVHY------ 521
            : |||:..:....:...|.:...:..|:.|||.......  ..|.|..|..|  |..||      
  Rat   145 E-ATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQDG--HDIENECLGMAVLAISHYAMMKKM 206

  Fly   522 ----LGEEIATSSTNPPD----------LTRLR--------------RTQCSMLCLGEDEEPVVL 558
                |.::|:.....|..          |||:|              :|.|.......|.:...|
  Rat   207 QLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYL 271

  Fly   559 ASPAPLTQLTAAVLTNTNNNHIYADLELDK--------------------------------KKD 591
            |:...||:...|.:..|:...|.::.||.:                                :|:
  Rat   272 ATLETLTKHYGAEIFETSMLLISSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQKPNVLPVEKE 336

  Fly   592 TSPSPECKGEQIQPKKEQIRIEINQTAPQNSID-----AHL---DRIDELNRVLDDRLKRTLQPS 648
            .:.....|.:..:.|||..|.::.:  ..||..     .|:   :.:..:|:..:..::..|...
  Rat   337 KNKLKRKKLDYNKHKKEDDRNKLRE--EWNSFSYFPEITHIVIKESVVSINKQDNKNMELKLSSH 399

  Fly   649 DD----VNAIE-----SAEENHIQTRKLAKDPDSQTKRSSSSSSEC------RSSKDTSHSKKRS 698
            ::    |:.::     :|:.:|.....:|........::......|      :..::.|......
  Rat   400 EEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYV 464

  Fly   699 LSFSQKSISNIFSNLKEFSKSPLV---RMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSS 760
            |.:|.....||...:..|.||.::   :..||..:..::.......|..|..|..|.        
  Rat   465 LRWSCTDFDNILMTVSCFEKSEVLGNQKQFKNFQIEVQKGRYSLHGSVDHFPSLRDL-------- 521

  Fly   761 SNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTF 825
                         .||...| .:.|..|:..:.......| :|.|.|....    ||::..:..:
  Rat   522 -------------MNHLKKQ-ILRTDNISFVLKRCCQPKP-REISNLLVAT----KKAQEWQPVY 567

  Fly   826 RSKLLNFQLKRSKPCKQ---CTKRRRIH-PSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKP 886
            ....|:|.....|...|   ..:..|.| .|.::.|:..:..:                 |.:|.
  Rat   568 SMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYKDDEGI-----------------AEEKK 615

  Fly   887 VKPSVQI--SGHKDHP---FESSSGELDENSD----------RDIDN---DEEEEDSASDDVLSM 933
            :|..:::  ..|:|..   ||::|.....:..          ||::|   :|..|....|..:..
  Rat   616 IKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHR 680

  Fly   934 KDHCYCVP-------SLAASISLSTNRPLYEEEWFHG---------------------------- 963
            |......|       .||:::|.     |.:::..||                            
  Rat   681 KSDALTTPWKFKVAKQLASALSY-----LEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPG 740

  Fly   964 ----VLPREEVVRLLNNDGDFLVRETIRNEESQIVLS-----------VCWNGHKHFIVQTTGEG 1013
                ||.|:|.:..:    .::..|.:.:.::..|.:           :|:||......:|..|.
  Rat   741 IPVSVLTRQECIERI----PWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEK 801

  Fly  1014 NFRFEG---PPFASIQELIMHQYHSELPVTVKSGAILRRPVCR------ERWELSNDDVV----- 1064
            ...:|.   |...|.:||      ::|.....:....:||..|      .:.|..|.|:|     
  Rat   802 ERFYESRCRPVTPSCKEL------ADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKQP 860

  Fly  1065 ------------LLERI---GRGNFGDV----YKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEG 1110
                        .|:||   |.|:||.|    |..:..:|...||||:.:............:|.
  Rat   861 ITEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEI 925

  Fly  1111 RILKQYDHPNIVKLIGICVQK--QPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGM 1173
            .||:...|.||||..|||::.  ..|.::||.:..|||..||.||.|.:..:||:........||
  Rat   926 EILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGM 990

  Fly  1174 RYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR----EEEEYIVSDGMKQIPVKWTAPEALNF 1234
            .||.|:..:||||||||.||:.||.|||.|||:::    ::|.|.|.|. :..||.|.|||.|..
  Rat   991 DYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDD-RDSPVFWYAPECLIQ 1054

  Fly  1235 GKYTSLCDVWSYGILMWEIFSKGDTPYS--------------GMTNSRARERIDTGYRMPTPKST 1285
            .|:....||||:|:.:.|:.:..|:.:|              .||.:|....:..|.|:..|.:.
  Rat  1055 CKFYIASDVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLSCPPNC 1119

  Fly  1286 PEEMYRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            |:|:|:||.:||.....:|..|..:....:||:
  Rat  1120 PDEVYQLMRKCWEFQPSNRTTFQNLIEGFEALL 1152

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341
SH2_Fps_family 953..1039 CDD:198224 20/131 (15%)
TyrKc 1063..1311 CDD:197581 97/291 (33%)
PTKc_Fes_like 1067..1315 CDD:270637 95/274 (35%)
Jak1NP_445918.1 B41 37..286 CDD:214604 41/208 (20%)
FERM_C_JAK1 282..426 CDD:275412 19/145 (13%)
SH2_Jak1 426..526 CDD:198241 18/120 (15%)
PTK_Jak1_rpt1 582..845 CDD:270662 47/294 (16%)
Pkinase_Tyr 582..844 CDD:285015 47/293 (16%)
PTKc_Jak1_rpt2 869..1152 CDD:173644 97/283 (34%)
Pkinase_Tyr 874..1146 CDD:285015 96/272 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100013
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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