Protein Alignment FER and Jak1

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_445918.1
• Gene: Jak1 / 84598
• RGDID: 69056
• Length: 1153
• Species: Rattus norvegicus
• Alignment Length: 1138
• Identity: 238/1138 - (20%)
• Similarity: 408/1138 - (35%)
• Gaps: 308/1138 - (27%)

  Fly   406 DDDLTLEQNFIENGY------NNEQQRSNSTSSPGLGIMNELMRRGGVLTLLRGRGRHFKRKSTP 464
            ||.::|..::....|      .|:.::|....||      :..:.|            :::|..|
  Rat    98 DDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSP------KKQKNG------------YEKKKVP 144

  Fly   465 QPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQA--ASVHY------ 521
            : |||:..:....:...|.:...:..|:.|||.......  ..|.|..|..|  |..||
  Rat   145 E-ATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQDG--HDIENECLGMAVLAISHYAMMKKM 206

  Fly   522 ----LGEEIATSSTNPPD----------LTRLR--------------RTQCSMLCLGEDEEPVVL 558
                |.::|:.....|..          |||:|              :|.|.......|.:...|
  Rat   207 QLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYL 271

  Fly   559 ASPAPLTQLTAAVLTNTNNNHIYADLELDK--------------------------------KKD 591
            |:...||:...|.:..|:...|.::.||.:                                :|:
  Rat   272 ATLETLTKHYGAEIFETSMLLISSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQKPNVLPVEKE 336

  Fly   592 TSPSPECKGEQIQPKKEQIRIEINQTAPQNSID-----AHL---DRIDELNRVLDDRLKRTLQPS 648
            .:.....|.:..:.|||..|.::.:  ..||..     .|:   :.:..:|:..:..::..|...
  Rat   337 KNKLKRKKLDYNKHKKEDDRNKLRE--EWNSFSYFPEITHIVIKESVVSINKQDNKNMELKLSSH 399

  Fly   649 DD----VNAIE-----SAEENHIQTRKLAKDPDSQTKRSSSSSSEC------RSSKDTSHSKKRS 698
            ::    |:.::     :|:.:|.....:|........::......|      :..::.|......
  Rat   400 EEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYV 464

  Fly   699 LSFSQKSISNIFSNLKEFSKSPLV---RMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSS 760
            |.:|.....||...:..|.||.::   :..||..:..::.......|..|..|..|.
  Rat   465 LRWSCTDFDNILMTVSCFEKSEVLGNQKQFKNFQIEVQKGRYSLHGSVDHFPSLRDL-------- 521

  Fly   761 SNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTF 825
                         .||...| .:.|..|:..:.......| :|.|.|....    ||::..:..:
  Rat   522 -------------MNHLKKQ-ILRTDNISFVLKRCCQPKP-REISNLLVAT----KKAQEWQPVY 567

  Fly   826 RSKLLNFQLKRSKPCKQ---CTKRRRIH-PSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKP 886
            ....|:|.....|...|   ..:..|.| .|.::.|:..:..:                 |.:|.
  Rat   568 SMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYKDDEGI-----------------AEEKK 615

  Fly   887 VKPSVQI--SGHKDHP---FESSSGELDENSD----------RDIDN---DEEEEDSASDDVLSM 933
            :|..:::  ..|:|..   ||::|.....:..          ||::|   :|..|....|..:..
  Rat   616 IKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHR 680

  Fly   934 KDHCYCVP-------SLAASISLSTNRPLYEEEWFHG---------------------------- 963
            |......|       .||:::|.     |.:::..||
  Rat   681 KSDALTTPWKFKVAKQLASALSY-----LEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPG 740

  Fly   964 ----VLPREEVVRLLNNDGDFLVRETIRNEESQIVLS-----------VCWNGHKHFIVQTTGEG 1013
                ||.|:|.:..:    .::..|.:.:.::..|.:           :|:||......:|..|.
  Rat   741 IPVSVLTRQECIERI----PWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEK 801

  Fly  1014 NFRFEG---PPFASIQELIMHQYHSELPVTVKSGAILRRPVCR------ERWELSNDDVV----- 1064
            ...:|.   |...|.:||      ::|.....:....:||..|      .:.|..|.|:|
  Rat   802 ERFYESRCRPVTPSCKEL------ADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKQP 860

  Fly  1065 ------------LLERI---GRGNFGDV----YKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEG 1110
                        .|:||   |.|:||.|    |..:..:|...||||:.:............:|.
  Rat   861 ITEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEI 925

  Fly  1111 RILKQYDHPNIVKLIGICVQK--QPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGM 1173
            .||:...|.||||..|||::.  ..|.::||.:..|||..||.||.|.:..:||:........||
  Rat   926 EILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGM 990

  Fly  1174 RYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR----EEEEYIVSDGMKQIPVKWTAPEALNF 1234
            .||.|:..:||||||||.||:.||.|||.|||:::    ::|.|.|.|. :..||.|.|||.|..
  Rat   991 DYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDD-RDSPVFWYAPECLIQ 1054

  Fly  1235 GKYTSLCDVWSYGILMWEIFSKGDTPYS--------------GMTNSRARERIDTGYRMPTPKST 1285
            .|:....||||:|:.:.|:.:..|:.:|              .||.:|....:..|.|:..|.:.
  Rat  1055 CKFYIASDVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLSCPPNC 1119

  Fly  1286 PEEMYRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            |:|:|:||.:||.....:|..|..:....:||:
  Rat  1120 PDEVYQLMRKCWEFQPSNRTTFQNLIEGFEALL 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	20/131 (15%)
		TyrKc	1063..1311	CDD:197581	97/291 (33%)
		PTKc_Fes_like	1067..1315	CDD:270637	95/274 (35%)
Jak1	NP_445918.1	B41	37..286	CDD:214604	41/208 (20%)
		FERM_C_JAK1	282..426	CDD:275412	19/145 (13%)
		SH2_Jak1	426..526	CDD:198241	18/120 (15%)
		PTK_Jak1_rpt1	582..845	CDD:270662	47/294 (16%)
		Pkinase_Tyr	582..844	CDD:285015	47/293 (16%)
		PTKc_Jak1_rpt2	869..1152	CDD:173644	97/283 (34%)
		Pkinase_Tyr	874..1146	CDD:285015	96/272 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810