DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and AT1G53440

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_175749.1	Gene:	AT1G53440 / 841779	AraportID:	AT1G53440	Length:	1035	Species:	Arabidopsis thaliana

Alignment Length:	960	Identity:	188/960 - (19%)
Similarity:	332/960 - (34%)	Gaps:	296/960 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   502 PARYEPITNHRLR-----QAASVHYLGEEIATSS----TNPPDLTRLRRTQCSMLCLGEDEEPVV 557
            |.....:|.:||.     |...:..|.:.|..|:    ..||:|..||..:            .:
plant   136 PLEILAVTGNRLSGPFPPQLGQITTLTDVIMESNLFTGQLPPNLGNLRSLK------------RL 188

  Fly   558 LASPAPLTQLTAAVLTNTNNNHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNS 622
            |.|...:|......|:|..|   ..:..:|....:...|:..|...:    .:|:::..|:.:..
plant   189 LISSNNITGRIPESLSNLKN---LTNFRIDGNSLSGKIPDFIGNWTR----LVRLDLQGTSMEGP 246

  Fly   623 IDAHLDRIDELNRVLDDRLKRTLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSS-------- 679
            |.|.:..:..|..:....|:....|..|:..:.:. |..:....|.::|..:...:|
plant   247 IPASISNLKNLTELRITDLRGPTSPFPDLQNMTNM-ERLVLRNCLIREPIPEYIGTSMTMLKLLD 310

  Fly   680 -SSSSECRSSKDTSHS---------KKRSLS-----FSQKSISNIFSNLKEFSKSPLV---RMGK 726
             ||:....:..||..|         ...||:     |...|..||..:...|::.|.:   ::..
plant   311 LSSNMLNGTIPDTFRSLNAFNFMYLNNNSLTGPVPQFILDSKQNIDLSYNNFTQPPTLSCNQLDV 375

  Fly   727 NHIL-------NEEQDAKRTQ---PSQHHHSS------GSDCPTNSSSSSSNNNNNNKNTSSNSN 775
            |.|.       |..|...|..   |...||||      |:....:....:.:.|....:|.|:.:
plant   376 NLISSYPSVTNNSVQWCLRKDLPCPGDAHHSSLFINCGGNRLKVDKDEYADDLNKRGASTFSSVS 440

  Fly   776 ----HSASQSTI----ITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAI------RNTFR 826
                :|:|.:.:    .|...|.|......:||.      .:|..::..:|...      |.:::
plant   441 ERWGYSSSGAWLGNDGATYLATDTFNLINESTPE------YYKTARLASQSLKYYGLCMRRGSYK 499

  Fly   827 SKLLNFQLKRSKPCKQCTKRRRIHPSKSVFD-------FAKEFEVEQPAGSAADEQFCNCPPAGQ 884
            .:|...::..|......:..||:      ||       ..::|.:.|.||...
plant   500 VQLYFAEIMFSNDQTYSSLGRRL------FDIYVQGILLERDFNIAQRAGGVG------------ 546

  Fly   885 KPVKP------SVQISGH--KDH-----------PFESSSGELDENSDRDIDNDEEEEDSASDDV 930
               ||      .||::|.  :.|           |.....|.|
plant   547 ---KPFLRQVDEVQVNGSTLEIHLKWTGKGTNVIPTRGVYGPL---------------------- 586

  Fly   931 LSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVL 995
                   ....::..:..:.|.:||     .:||:                         :.||:
plant   587 -------ISAITVTPNFKVDTGKPL-----SNGVV-------------------------AGIVI 614

  Fly   996 SVCWNGHKHF------IVQTTG-------EGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAIL 1047
            :.|    ..|      |::.||       :.|....|                   :.:::|:..
plant   615 AAC----VAFGLLVLVILRLTGYLGGKEVDENEELRG-------------------LDLQTGSFT 656

  Fly  1048 RRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQ-KRKFLQEGR 1111
            .:.:.|.......::     :||.|.||.|||..| :..:.:|||  :::...:| .|:|:.|..
plant   657 LKQIKRATNNFDPEN-----KIGEGGFGPVYKGVL-ADGMTIAVK--QLSSKSKQGNREFVTEIG 713

  Fly  1112 ILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGL----TTRQQMGM------- 1165
            ::....|||:|||.|.|::.:.:::|.|         ||..||...    |.:|::.:
plant   714 MISALQHPNLVKLYGCCIEGKELLLVYE---------YLENNSLARALFGTEKQRLHLDWSTRNK 769

  Fly  1166 -CRDAAAGMRYLESKN---CIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPV 1224
             |...|.|:.||..::   .:|||:.|.|.|:||..:.||||||:::  |||...:|..:.. .:
plant   770 VCIGIAKGLAYLHEESRLKIVHRDIKATNVLLDLSLNAKISDFGLAKLDEEENTHISTRIAG-TI 833

  Fly  1225 KWTAPEALNFGKYTSLCDVWSYGILMWEIFS-KGDTPYSGMTNSRARER----IDTGYRMPTPKS 1284
            .:.|||....|..|...||:|:|::..||.| |.:|.|      |.:|.    :|..|.:....|
plant   834 GYMAPEYAMRGYLTDKADVYSFGVVCLEIVSGKSNTNY------RPKEEFIYLLDWAYVLQEQGS 892

  Fly  1285 TPE----------------EMYRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            ..|                .|..:.|.|.......||....:.:::...|
plant   893 LLELVDPDLGTSFSKKEAMRMLNIALLCTNPSPTLRPPMSSVVSMLQGKI 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	13/98 (13%)
		TyrKc	1063..1311	CDD:197581	81/286 (28%)
		PTKc_Fes_like	1067..1315	CDD:270637	81/286 (28%)
AT1G53440	NP_175749.1	PLN00113	74..939	CDD:215061	187/955 (20%)
		leucine-rich repeat	90..113	CDD:275380
		leucine-rich repeat	114..135	CDD:275380
		leucine-rich repeat	137..160	CDD:275380	4/22 (18%)
		leucine-rich repeat	161..184	CDD:275380	7/22 (32%)
		leucine-rich repeat	185..208	CDD:275380	5/34 (15%)
		leucine-rich repeat	209..232	CDD:275380	3/22 (14%)
		leucine-rich repeat	233..256	CDD:275380	4/22 (18%)
		leucine-rich repeat	257..280	CDD:275380	4/22 (18%)
		leucine-rich repeat	281..305	CDD:275380	4/24 (17%)
		leucine-rich repeat	306..327	CDD:275380	4/20 (20%)
		STKc_IRAK	673..940	CDD:270968	81/285 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910