DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Src

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_114183.1	Gene:	Src / 83805	RGDID:	620795	Length:	542	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	170/555 - (30%)
Similarity:	256/555 - (46%)	Gaps:	122/555 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   836 RSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKD-- 898
            :|||.....:||.:.|:::|          ..||.|.        ||.|.|.||: ...||:.
  Rat     5 KSKPKDASQRRRSLEPAENV----------HGAGGAF--------PASQTPSKPA-SADGHRGPN 50

  Fly   899 ---------HP-----FESS--------SGEL-------------DENSDRDID----------N 918
                     .|     |.||        :|.|             :..::.|:.          |
  Rat    51 AAFVPPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVN 115

  Fly   919 DEEEEDSASDD-----VLSMKDHCYCVPS--LAASISLSTNRPLYEEEWFHGVLPREEVVRLL-- 974
            :..:.|....|     .||.....| :||  :|.|.|:..      |||:.|.:.|.|..|||
  Rat   116 NTRKVDVREGDWWLAHSLSTGQTGY-IPSNYVAPSDSIQA------EEWYFGKITRRESERLLLN 173

  Fly   975 --NNDGDFLVRE----------TIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEG-PPFASIQ 1026
              |..|.|||||          ::.:.::...|:|     ||:.::....|.|.... ..|.|:|
  Rat   174 AENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV-----KHYKIRKLDSGGFYITSRTQFNSLQ 233

  Fly  1027 ELIMHQYHSE--------LPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLK 1083
            :|:  .|:|:        |.....:.....:.:.::.||:..:.:.|..::|:|.||:|:.....
  Rat   234 QLV--AYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWN 296

  Fly  1084 STKLDVAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLL 1147
            .| ..||:||.:. |:..|   .||||.:::|:..|..:|:|..: |.::||.||.|.:..||||
  Rat   297 GT-TRVAIKTLKPGTMSPE---AFLQEAQVMKKLRHEKLVQLYAV-VSEEPIYIVTEYMNKGSLL 356

  Fly  1148 TYLRKNSNG--LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR-- 1208
            .:| |...|  |...|.:.|....|:||.|:|..|.:||||.|.|.||......|::|||::|
  Rat   357 DFL-KGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI 420

  Fly  1209 EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERI 1273
            |:.||....|.| .|:|||||||..:|::|...||||:|||:.|:.:||..||.||.|....:::
  Rat   421 EDNEYTARQGAK-FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 484

  Fly  1274 DTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFD 1308
            :.|||||.|...||.::.||.|||..:.|.||.|:
  Rat   485 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFE 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	29/108 (27%)
		TyrKc	1063..1311	CDD:197581	103/251 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	102/247 (41%)
Src	NP_114183.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49		18/62 (29%)
		SH3_Src	88..149	CDD:212941	10/61 (16%)
		SH2_Src_Src	153..253	CDD:198228	29/112 (26%)
		PTKc_Src	266..542	CDD:270656	105/261 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910