DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and VIK

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_172853.1	Gene:	VIK / 837960	AraportID:	AT1G14000	Length:	438	Species:	Arabidopsis thaliana

Alignment Length:	406	Identity:	109/406 - (26%)
Similarity:	179/406 - (44%)	Gaps:	82/406 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   939 CVPSLAASISLS---TNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWN 1000
            |:....|.::..   .|.||.:.|...    :::::.||.:.|.               ||...|
plant    89 CLLEFGADVNAQDRWKNTPLADAEGAR----KQKMIELLKSHGG---------------LSYGQN 134

  Fly  1001 GHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWEL--SNDDV 1063
            | .||..:..         ||                |:..|..           ||:  :..|.
plant   135 G-SHFEPKPV---------PP----------------PIPKKCD-----------WEIEPAELDF 162

  Fly  1064 VLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQK--RKFLQEGRILKQYDHPNIVKLIG 1126
            .....||:|:||::.||..:.|  .||||....:|.|::.  :.|..|..:|.:..|||||:.:|
plant   163 SNAAMIGKGSFGEIVKAYWRGT--PVAVKRILPSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLG 225

  Fly  1127 ICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYL--ESKNCIHRDLAAR 1189
            ...:::|:|::.|.:.||.|..|| |...|||....:....|.|.||.||  |....|||||..|
plant   226 AVTERKPLMLITEYLRGGDLHQYL-KEKGGLTPTTAVNFALDIARGMTYLHNEPNVIIHRDLKPR 289

  Fly  1190 NCLV---DLEHSVKISDFGMSREEEEYIVSDGMKQI----PVKWTAPEALNFGKYTSLCDVWSYG 1247
            |.|:   ..:| :|:.|||:|:..:.....|..|..    ..::.|||.....:|....||:|:.
plant   290 NVLLVNSSADH-LKVGDFGLSKLIKVQNSHDVYKMTGETGSYRYMAPEVFKHRRYDKKVDVFSFA 353

  Fly  1248 ILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKS---TPEEMYRLMLQCWAADAESRPHFDE 1309
            ::::|:. :|:.|::......|.:.:..|:| ||.:|   || ::..|:::||.||...||.|.:
plant   354 MILYEML-EGEPPFANHEPYEAAKHVSDGHR-PTFRSKGCTP-DLRELIVKCWDADMNQRPSFLD 415

  Fly  1310 IYNVVDALILRLDNSH 1325
            |...::.:...|.:.|
plant   416 ILKRLEKIKETLPSDH 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	14/85 (16%)
		TyrKc	1063..1311	CDD:197581	84/261 (32%)
		PTKc_Fes_like	1067..1315	CDD:270637	85/261 (33%)
VIK	NP_172853.1	ANK repeat	36..68	CDD:293786
		PTZ00322	45..>126	CDD:140343	8/40 (20%)
		ANK repeat	70..101	CDD:293786	2/11 (18%)
		ANK repeat	103..127	CDD:293786	6/27 (22%)
		STKc_MAP3K-like	168..420	CDD:270901	85/258 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810