DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and STY17

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_195303.2	Gene:	STY17 / 829731	AraportID:	AT4G35780	Length:	570	Species:	Arabidopsis thaliana

Alignment Length:	513	Identity:	131/513 - (25%)
Similarity:	221/513 - (43%)	Gaps:	103/513 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   865 EQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEE------ 923
            |.||.....|..|             ||:|    .....:||::|. ||..::.|.:..
plant    93 EDPATRPVFEVRC-------------VQVS----PTLNGNSGDVDP-SDPAVNEDAQSSYNSRSL 139

  Fly   924 ------DSASDDVLSM--KDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNN---- 976
                  .|.:.:.|:.  |||.....| |.:..|..:||::|..:  ..:.|.:::..|.:
plant   140 APPTFGSSPNFEALTQAYKDHAQDDDS-AVNAQLPNSRPMHEITF--STIDRPKLLSQLTSMLGE 201

  Fly   977 --------------DG---DFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFAS 1024
                          ||   |..|.:....||::        |.|..:.:...    :|:..| .|
plant   202 LGLNIQEAHAFSTADGFSLDVFVVDGWSQEETE--------GLKDALKKEIR----KFKDQP-CS 253

  Fly  1025 IQELIMHQYHSELPVTVKSGAILRRPVCRE-------RWELSNDDVVLLERIGRGNFGDVYKAKL 1082
            .|:.|....|.:     .:..:|  |.|.|       .||:....:.:.:::..|::|::::...
plant   254 KQKSITFFEHDK-----STNELL--PACVEIPTDGTDEWEIDMKQLKIEKKVACGSYGELFRGTY 311

  Fly  1083 KSTKLDVAVKTCRMTLPD----EQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLG 1143
            .|.  :||:|..:   |:    |..|:|.||..|:::..|.|:|:.||.|.:...:.||.|.:..
plant   312 CSQ--EVAIKILK---PERVNAEMLREFSQEVYIMRKVRHKNVVQFIGACTRSPNLCIVTEFMTR 371

  Fly  1144 GSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR 1208
            ||:..:|.|:......:..:.:..|.:.||.||...|.|||||...|.|:|....||::|||::|
plant   372 GSIYDFLHKHKGVFKIQSLLKVALDVSKGMNYLHQNNIIHRDLKTANLLMDEHEVVKVADFGVAR 436

  Fly  1209 EEEEYIVSDGMKQIPV---KWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRAR 1270
            .:.|    .|:.....   :|.|||.:....|....||:||.|::||:.: |:.|||.:|..:|.
plant   437 VQTE----SGVMTAETGTYRWMAPEVIEHKPYDHRADVFSYAIVLWELLT-GELPYSYLTPLQAA 496

  Fly  1271 ER-IDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRL--DNSH 1325
            .. :..|.|...||.|..::..|:.:||..|...||:|.||..:::.||..:  |..|
plant   497 VGVVQKGLRPKIPKETHPKLTELLEKCWQQDPALRPNFAEIIEMLNQLIREVGDDERH 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	19/106 (18%)
		TyrKc	1063..1311	CDD:197581	79/255 (31%)
		PTKc_Fes_like	1067..1315	CDD:270637	80/255 (31%)
STY17	NP_195303.2	ACT_TyrKc	178..244	CDD:153200	11/75 (15%)
STY17	NP_195303.2	STKc_MAP3K-like	301..541	CDD:270901	80/249 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910