DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and CERK1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_566689.2	Gene:	CERK1 / 821717	AraportID:	AT3G21630	Length:	617	Species:	Arabidopsis thaliana

Alignment Length:	534	Identity:	121/534 - (22%)
Similarity:	206/534 - (38%)	Gaps:	152/534 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   877 CNCPPAG-----------QKPVKPSVQISGHKD----------HPFESSSGELDENSDRDIDNDE 920
            |.|.|..           |:.....|.||.:.:          :||.:::..|
plant    91 CECQPGDFLGHNFSYSVRQEDTYERVAISNYANLTTMESLQARNPFPATNIPL------------ 143

  Fly   921 EEEDSASDDVLSMKDHCYC-VPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRE 984
                ||:.:||.   :|.| ..|::....|....||..|:      ....:.|......|.|.|
plant   144 ----SATLNVLV---NCSCGDESVSKDFGLFVTYPLRPED------SLSSIARSSGVSADILQR- 194

  Fly   985 TIRNEESQIVLSVCWNGHKHF-----IVQTTG-EGNFRFEGPPFASIQE---------------- 1027
                          :|...:|     ||...| :.|..|  |||.|.::
plant   195 --------------YNPGVNFNSGNGIVYVPGRDPNGAF--PPFKSSKQDGVGAGVIAGIVIGVI 243

  Fly  1028 --------LIMHQYH----------SELPVTVKS--------------GAILRRPVCR------- 1053
                    ::.:.|.          |.:|::.|:              ||.:...:..
plant   244 VALLLILFIVYYAYRKNKSKGDSFSSSIPLSTKADHASSTSLQSGGLGGAGVSPGIAAISVDKSV 308

  Fly  1054 ----ERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILK 1114
                |....:.|:..|..:||:|.||.||.|:|:..|  .|:|...|    |..::||.|.::|.
plant   309 EFSLEELAKATDNFNLSFKIGQGGFGAVYYAELRGEK--AAIKKMDM----EASKQFLAELKVLT 367

  Fly  1115 QYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSN---GLTTRQQMGMCRDAAAGMRYL 1176
            :..|.|:|:|||.||:.. :.:|.|.|..|:|..:|..:..   ..|.|.|:.:  |:|.|:.|:
plant   368 RVHHVNLVRLIGYCVEGS-LFLVYEYVENGNLGQHLHGSGREPLPWTKRVQIAL--DSARGLEYI 429

  Fly  1177 ESKNC---IHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYT 1238
            .....   :|||:.:.|.|:|.:...|::|||:::..|....:.........:.|||.: :|:.:
plant   430 HEHTVPVYVHRDIKSANILIDQKFRAKVADFGLTKLTEVGGSATRGAMGTFGYMAPETV-YGEVS 493

  Fly  1239 SLCDVWSYGILMWEIFS-KGDTPYSGMTNSRARERIDTGYRMPTPKST-PEEMYRLMLQCWAADA 1301
            :..||:::|::::|:.| ||  ....||.:....|...|....:.|.| .||..|.::.....|
plant   494 AKVDVYAFGVVLYELISAKG--AVVKMTEAVGEFRGLVGVFEESFKETDKEEALRKIIDPRLGD- 555

  Fly  1302 ESRPHFDEIYNVVD 1315
             |.| ||.:|.:.:
plant   556 -SYP-FDSVYKMAE 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	20/125 (16%)
		TyrKc	1063..1311	CDD:197581	76/255 (30%)
		PTKc_Fes_like	1067..1315	CDD:270637	76/255 (30%)
CERK1	NP_566689.2	mltD	<104..202	CDD:182727	23/137 (17%)
CERK1	NP_566689.2	PKc_like	328..587	CDD:419665	76/255 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910