DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Musk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_112323.2	Gene:	Musk / 81725	RGDID:	3211	Length:	868	Species:	Rattus norvegicus

Alignment Length:	916	Identity:	206/916 - (22%)
Similarity:	338/916 - (36%)	Gaps:	261/916 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   600 GEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDEL----------------NRVL----DDRLK-- 642
            |.:..||...|      |.|..::||.::.:...                |::|    |.|..
  Rat    20 GTEKLPKAPVI------TTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIR 78

  Fly   643 --------RTLQPSDD-----------VNAIESAEENHIQTRKLAKDPDSQTK--RSSSSSSECR 686
                    .:::.|||           ..|:||.....::.:.....|....|  ....:...|
  Rat    79 ENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPC- 142

  Fly   687 SSKDTSHSKKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHILN-EEQDAKRTQ---------- 740
               .|..:.|.|:|:.:..     |.|:|.|:..::..|...|.| :::||.:.:
  Rat   143 ---TTMGNPKPSVSWIKGD-----SALRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTA 199

  Fly   741 ------------------PSQHHHSSGS---------DCPTNSSSSSSNNNNNNKNTSSNSNHSA 778
                              |..|:.:.||         ..|..:.|...|.|    ..||.|....
  Rat   200 YSKLVKLEVEVFARILRAPESHNVTFGSFVTLRCTAIGMPVPTISWIENGN----AVSSGSIQEN 260

  Fly   779 SQSTIITSTITTTIT-----TTTTTTPSKENSRLKFKVPKI------------QKKSKAIRNTFR 826
            .:..:|.|.:...||     |...|....|    ||...|.            ||:||.....:|
  Rat   261 VKDRVIDSRLQLFITKPGLYTCIATNKHGE----KFSTAKAAATVSIAEWSKSQKESKGYCAQYR 321

  Fly   827 SKLLNFQLKR--------SKPCKQCTKRRRIHPSKSVFDFAKEFEVEQP-AGSAADEQFCNCPPA 882
            .::.:..|.:        |.|..:..:...||.:.:      |.:...| ...||:...||
  Rat   322 GEVCDAVLVKDSLVFFNTSYPDPEEAQELLIHTAWN------ELKAVSPLCRPAAEALLCN---- 376

  Fly   883 GQKPVKPSVQISGHKDHPF-ESSSGELDENSDRDIDND---EEEEDSASDDVLSM--KDH----- 936
                            |.| |.|||.|.  :...|..:   ..:|...:.:.|:|  |.|
  Rat   377 ----------------HLFQECSSGVLP--TPMPICREYCLAVKELFCAKEWLAMEGKTHRGLYR 423

  Fly   937 ----------CYCVPSLAASISLSTNRPL--YEEE---WFHGVL---PREEVVRLLNNDGDFLVR 983
                      |..:||:....:..|..|.  |::|   .|..:.   |..::..|..:...|.|.
  Rat   424 SGMHFLPVPECSKLPSMHQDPTACTRLPYLDYKKENITTFPSITSSKPSVDIPNLPASTSSFAVS 488

  Fly   984 ETIRNEESQIVLSV-----------------C-----WNGHKH---FIVQTTGEGNFRFEGPPFA 1023
            ...   ...:::|:                 |     |...|.   .:..||
  Rat   489 PAY---SMTVIISIMSCFAVFALLTITTLYCCRRRREWKNKKRESAAVTLTT------------- 537

  Fly  1024 SIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTK-- 1086
            ...||::.:.|.. |:..:...:|...:....:..:|.:.|  ..||.|.||.|::|:.....
  Rat   538 LPSELLLDRLHPN-PMYQRMPLLLNPKLLSLEYPRNNIEYV--RDIGEGAFGRVFQARAPGLLPY 599

  Fly  1087 ---LDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLT 1148
               ..||||..:.....:.:..|.:|..::.::|:||||||:|:|...:|:.::.|.:..|.|..
  Rat   600 EPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNE 664

  Fly  1149 YLRKNS---------NGLTTR--------------QQMGMCRDAAAGMRYLESKNCIHRDLAARN 1190
            :||..|         :.|:||              :|:.:.|..||||.||..:..:|||||.||
  Rat   665 FLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRN 729

  Fly  1191 CLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEI 1253
            |||.....|||:|||:||.  ..:|..:||...||::|..||::.:.:||:..|||:||:::|||
  Rat   730 CLVGENMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEI 794

  Fly  1254 FSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            ||.|..||.||.:......:..|..:..|::.|.|:|.||..||:.....||.|..|:.::..:.
  Rat   795 FSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQRMC 859

  Fly  1319 LRLDNS 1324
            .|.:.:
  Rat   860 ERAEGT 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	17/118 (14%)
		TyrKc	1063..1311	CDD:197581	96/277 (35%)
		PTKc_Fes_like	1067..1315	CDD:270637	96/277 (35%)
Musk	NP_112323.2	IgI_1_MuSK	28..117	CDD:409562	15/94 (16%)
		Ig strand B	45..49	CDD:409562	0/3 (0%)
		Ig strand C	58..62	CDD:409562	0/3 (0%)
		Ig strand E	82..86	CDD:409562	0/3 (0%)
		Ig strand F	96..101	CDD:409562	0/4 (0%)
		Ig strand G	110..113	CDD:409562	2/2 (100%)
		IgI_2_MuSK	122..209	CDD:409560	16/95 (17%)
		Ig strand B	138..142	CDD:409560	0/3 (0%)
		Ig strand C	151..155	CDD:409560	2/3 (67%)
		Ig strand E	173..177	CDD:409560	1/3 (33%)
		Ig strand F	187..192	CDD:409560	0/4 (0%)
		Ig strand G	201..204	CDD:409560	0/2 (0%)
		Ig_3	218..286	CDD:404760	16/71 (23%)
		Ig strand A'	222..225	CDD:409353	0/2 (0%)
		Ig strand B	229..236	CDD:409353	0/6 (0%)
		Ig strand C	242..247	CDD:409353	1/4 (25%)
		Ig strand C'	250..252	CDD:409353	1/5 (20%)
		Ig strand D	258..262	CDD:409353	0/3 (0%)
		Ig strand E	268..272	CDD:409353	1/3 (33%)
		Ig strand F	278..286	CDD:409353	1/7 (14%)
		CRD_TK_ROR_related	313..457	CDD:143578	33/171 (19%)
		PTKc_Musk	568..857	CDD:133181	98/290 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910