DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Lyn

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_110484.1	Gene:	Lyn / 81515	RGDID:	621017	Length:	512	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	158/494 - (31%)
Similarity:	237/494 - (47%)	Gaps:	99/494 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   884 QKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEE----------DSASDDVLSMK---- 934
            |:||..|..:.|.:   |::              .|.||:          |....|.||.|
  Rat    42 QRPVPESQLLPGQR---FQA--------------KDPEEQGDIVVALYPYDGIHPDDLSFKKGEK 89

  Fly   935 -----DHCYCVPSLAASISLSTNR-------------PLYEEEWFHGVLPREEVVRLL----NND 977
                 :|    .....:.|||:.|             .|..||||...:.|::..|.|    |:.
  Rat    90 MKVLEEH----GEWWKAKSLSSKREGFIPSNYVAKVNTLETEEWFFKDITRKDAERQLLAPGNSA 150

  Fly   978 GDFLVR--ETIRNEESQIVLSV----CWNGH--KHFIVQTTGEGNFRFEGP--PFASIQELIMHQ 1032
            |.||:|  ||::...|   |||    ..:|.  ||:.:::...|.: :..|  .|..|.::|.|
  Rat   151 GAFLIRESETLKGSFS---LSVRDYDPMHGDVIKHYKIRSLDNGGY-YISPRITFPCISDMIKH- 210

  Fly  1033 YHSELPVTVKSGAILRR------------PVCRERWELSNDDVVLLERIGRGNFGDVYKAKL-KS 1084
            |..:      |..:.||            |..::.||:..:.:.|::::|.|.||:|:.... .|
  Rat   211 YQKQ------SDGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKKLGAGQFGEVWMGYYNNS 269

  Fly  1085 TKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTY 1149
            ||  |||||.:......|  .||:|..::|...|..:|:|..:..:::||.|:.|.:..||||.:
  Rat   270 TK--VAVKTLKPGTMSAQ--AFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDF 330

  Fly  1150 LRKNSNG-LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEE 1211
            |:.:... :...:.:......|.||.|:|.||.|||||.|.|.||......||:|||::|  |:.
  Rat   331 LKSDEGSKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDN 395

  Fly  1212 EYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTG 1276
            ||...:|.| .|:|||||||:|||.:|...||||:|||::||.:.|..||.|.||:.....:..|
  Rat   396 EYTAREGAK-FPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQG 459

  Fly  1277 YRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVD 1315
            ||||..::.|:|:|.:|..||...||.||.||.:.:|:|
  Rat   460 YRMPRMENCPDELYDIMKMCWKESAEERPTFDYLQSVLD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	30/112 (27%)
		TyrKc	1063..1311	CDD:197581	102/251 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	102/251 (41%)
Lyn	NP_110484.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		4/7 (57%)
		SH3_Lyn	67..122	CDD:212937	10/58 (17%)
		SH2_Src_Lyn	125..225	CDD:198227	31/110 (28%)
		PTKc_Lyn	239..510	CDD:270657	106/265 (40%)
		Pkinase_Tyr	247..497	CDD:285015	102/254 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910