Protein Alignment FER and itk

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_571179.1
• Gene: itk / 798906
• ZFINID: ZDB-GENE-990415-261
• Length: 616
• Species: Danio rerio
• Alignment Length: 542
• Identity: 175/542 - (32%)
• Similarity: 260/542 - (47%)
• Gaps: 89/542 - (16%)

  Fly   833 QLKRSKPCKQCTKRR----RIHPSKSVFDFAKE-----FEVEQPAGSAADEQFCNCPPAGQKPVK 888
            :||..|..|:..:..    :.||     ||..|     .:..:...:...|.:    |.|.||:.
Zfish    99 RLKWVKALKEAIQNNSLFLKYHP-----DFWGEGKWRCCQQTEKLATGCSEYY----PNGAKPLP 154

  Fly   889 PSVQISGHKDHPFESSSGEL-----DENSDRDIDNDEEE--EDSASDDVLSMKD---HCYCVPSL 943
            |:...|.....|.|.....|     .|::|..:..|||.  .|.:..:..::||   :...||.:
Zfish   155 PTPDPSRRSSEPEERIVVALRNFIPKEHTDLPLQKDEEYFIVDCSEPNWWTVKDKDGNVGSVPCI 219

  Fly   944 AASISLSTNRPLYEEEWFHGVLPREEVVRLL---NNDGDFLVRETIRNEESQIVLSVC------- 998
            ..:..||.|  :.:.||::..:.|.|...||   |.||.|:|    ||.:...|.:|.
Zfish   220 YVTEKLSNN--IEKFEWYNKDINRTEAEDLLMQENKDGGFMV----RNSKHAGVYTVSIFTRVSG 278

  Fly   999 WNGH-----KHFIVQTTGEGN----FRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVC-- 1052
            .||.     ||:.::...||.    :..|...|.:|.|||  :||...|    :|.|.|...|
Zfish   279 SNGEKCPQVKHYQIKVQSEGEKVLYYLAEKYLFPTIPELI--RYHQHNP----AGLITRLRHCVS 337

  Fly  1053 -------------RERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKR 1104
                         .::||:..|:|.|...:|.|.||.|:|...:..  :|||||.|.....|:
Zfish   338 RNVPNSARIKELSSDKWEIHPDEVKLSVELGSGQFGLVWKGSWQDR--EVAVKTVREGFMSEE-- 398

  Fly  1105 KFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDA 1169
            :|.:|.:::.:..|..:|:|.|:..|:.||.:|.|.:..|.|..:||.....|:.:..:.||.|.
Zfish   399 EFKEEAQVMMKLSHNRLVQLYGVVTQRSPIYLVFEFMENGCLTEFLRAKKGKLSQKALLEMCLDV 463

  Fly  1170 AAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEAL 1232
            :.||.||||.|.||||||||||||.....|||:||||:|  .:::|..|.|.| .||:|::||.:
Zfish   464 SEGMAYLESSNFIHRDLAARNCLVSENSVVKIADFGMTRFVLDDQYTSSHGSK-FPVRWSSPEVI 527

  Fly  1233 NFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCW 1297
            .||||:|..||||:|:.|||::|:|.|||...:||...|.::.|:|:..|:..|:.:|.||...|
Zfish   528 KFGKYSSKSDVWSFGVFMWEVYSEGRTPYDNRSNSEVVETLNAGHRLLKPRLCPQSVYELMQWSW 592

  Fly  1298 AADAESRPHFDEIYNVVDALIL 1319
            ....|.||.|        ||:|
Zfish   593 KEKPEDRPSF--------ALLL 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	29/104 (28%)
		TyrKc	1063..1311	CDD:197581	103/249 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	101/249 (41%)
itk	NP_571179.1	PH	5..110	CDD:278594	4/10 (40%)
		PH_Btk	7..147	CDD:269944	10/56 (18%)
		SH3_Tec_like	170..223	CDD:212702	11/52 (21%)
		SH2_Tec_family	227..338	CDD:198188	35/122 (29%)
		PKc_like	356..610	CDD:304357	107/264 (41%)
		Pkinase_Tyr	361..609	CDD:285015	106/259 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910