DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Fgfr1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_077060.1	Gene:	Fgfr1 / 79114	RGDID:	620713	Length:	822	Species:	Rattus norvegicus

Alignment Length:	753	Identity:	171/753 - (22%)
Similarity:	274/753 - (36%)	Gaps:	212/753 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   721 LVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIIT 785
            |....:..|..||.:.:.:.|:.   |....|.|||.                   |.|.:|..:
  Rat    73 LAESNRTRITGEEVEVRDSIPAD---SGLYACVTNSP-------------------SGSDTTYFS 115

  Fly   786 STITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIH 850
            ..::..:.::.......::|          .:.|...||             ||     .||.:.
  Rat   116 VNVSDALPSSEDDDDDDDSS----------SEEKETDNT-------------KP-----NRRPVA 152

  Fly   851 PSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQ-----------KPVKPSVQISGHK------- 897
            |   .:...::.|.:..|..||......||.:|.           |..||..:|.|:|
  Rat   153 P---YWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPSPTLRWLKNGKEFKPDHRIGGYKVRYATWS 214

  Fly   898 ---DHPFESSSGE---LDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAA------SISLS 950
               |....|..|.   :.||....|::..:.      ||:....|   .|.|.|      :::|.
  Rat   215 IIMDSVVPSDKGNYTCIVENEYGSINHTYQL------DVVERSPH---RPILQAGLPANKTVALG 270

  Fly   951 TN---------RPLYEEEWFHGV-----------LPREEV-----VRLLNNDGDFLVRETIRNEE 990
            :|         .|....:|...:           ||.:::     |...:.:.:.|....:..|:
  Rat   271 SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYDQILKTAGVNTTDKEMEVLHLRNVSFED 335

  Fly   991 SQIVLSVCWN--GHKHF-----IVQTTGEGNFRFEGPPFASI----------------------- 1025
            :.....:..|  |..|.     :::...|.......|.:..|
  Rat   336 AGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIIYKMK 400

  Fly  1026 ---------QELIMHQYHSELP----VTV--------KSGAILRRPVCRE--------------- 1054
                     .::.:|:....:|    |||        .||.:|.||....
  Rat   401 SGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYEL 465

  Fly  1055 ----RWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLD-------VAVKTCRMTLPDEQKRKFLQ 1108
                ||||..|.:||.:.:|.|.||.|..|:......|       ||||..:....::.....:.
  Rat   466 PEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLIS 530

  Fly  1109 EGRILKQY-DHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN---------------SNGL 1157
            |..::|.. .|.||:.|:|.|.|..|:.:::|....|:|..||:..               ...|
  Rat   531 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQL 595

  Fly  1158 TTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMK 1220
            :::..:......|.||.||.||.||||||||||.||..::.:||:|||::|:  ..:|.......
  Rat   596 SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 660

  Fly  1221 QIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKST 1285
            ::||||.|||||....||...||||:|:|:||||:.|.:|..|:......:.:..|:||..|.:.
  Rat   661 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPNPGVPVEELFKLLKEGHRMDKPSNC 725

  Fly  1286 PEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDN 1323
            ..|:|.:|..||.|....||.|.::...:|.::....|
  Rat   726 TNELYMMMRDCWNAVPSQRPTFKQLVEDLDRIVALTSN 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	15/144 (10%)
		TyrKc	1063..1311	CDD:197581	92/272 (34%)
		PTKc_Fes_like	1067..1315	CDD:270637	90/272 (33%)
Fgfr1	NP_077060.1	Ig1_FGFR	40..118	CDD:143174	13/66 (20%)
		IG_like	41..118	CDD:214653	13/66 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..162		9/72 (13%)
		I-set	160..247	CDD:254352	19/92 (21%)
		Heparin-binding	160..177		4/16 (25%)
		Ig2_FGFR	163..247	CDD:143265	18/89 (20%)
		IG_like	262..358	CDD:214653	12/95 (13%)
		Ig3_FGFR	270..359	CDD:143175	11/88 (13%)
		PTKc_FGFR1	464..765	CDD:270678	99/300 (33%)
		Pkinase_Tyr	478..754	CDD:285015	92/275 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..822
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810